The Journal of Pain
Volume 7, Issue 10 , Pages 735-746 , October 2006

Design and Characterization of a Noncompetitive Antagonist of the Transient Receptor Potential Vanilloid Subunit 1 Channel With In Vivo Analgesic and Anti-inflammatory Activity

  • Carolina García-Martínez

      Affiliations

    • Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain
    • ,
  • Asia Fernández-Carvajal

      Affiliations

    • Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain
    • ,
  • Belen Valenzuela

      Affiliations

    • División de Farmacia y Tecnología Farmacéutica, Dpto Ingeniería, Universidad Miguel Hernández, Alicante, Spain
    • ,
  • Ana Gomis

      Affiliations

    • Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Alicante, Spain
    • ,
  • Wim Van Den Nest

      Affiliations

    • DiverDrugs, SL, Gavà, Barcelona, Spain
    • ,
  • Stefano Ferroni

      Affiliations

    • Department of Human and General Physiology, University of Bologna, Bologna, Italy
    • ,
  • Cristina Carreño

      Affiliations

    • DiverDrugs, SL, Gavà, Barcelona, Spain
    • ,
  • Carlos Belmonte

      Affiliations

    • Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Alicante, Spain
    • ,
  • Antonio Ferrer-Montiel

      Affiliations

    • Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain
    • Corresponding Author InformationAddress reprint requests to Antonio Ferrer-Montiel, MD, Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Ed. Torregaitán, Av de la Universidad s/n, 03202 Elche (Alicante), Spain.

Received 1 December 2005 ,Revised 14 March 2006 ,Accepted 27 March 2006.

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 Supported by grants from the Ministerio de Educacion Ciencia y Deporte (SAF 2003/0509), La Fundación Ramón Areces (01/08-500), and Generalitat Valenciana (GV04B-0398) to A.F.M., PROFIT-090000-2001-70 and CDTI-03-006 (Ministerio de Industria) to DiverDrugs, SL.

PII: S1526-5900(06)00686-9

doi: 10.1016/j.jpain.2006.03.008

The Journal of Pain
Volume 7, Issue 10 , Pages 735-746 , October 2006

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