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The Journal of Pain
Volume 8, Issue 7
, Pages 556-562
, July 2007
α1-Adrenergic Receptors Augment P2X3 Receptor–Mediated Nociceptive Responses in the Uninjured State
References
- . Multiple receptors involved in peripheral α2, μ, and A1 antinociception, tolerance, and withdrawal. J Neurosci. 1997;17:735–744
- . Differences between the Lewis and Sprague-Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors. Neurosci Lett. 2001;299:21–24
- . Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br J Pharmacol. 1997;122:365–371
- . The expression of P2X3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci. 1998;12:256–268
- . Noradrenaline and ATP: Cotransmitters and neuromodulators. J Physiol Pharmacol. 1995;46:365–384
- . Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain. 2005;119:38–48
- . Changes in the α2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain. NeuroReport. 1997;8:3119–3122
- . α-Adrenergic receptor subtypes in rat dorsal root and superior cervical ganglion neurons. Pain. 1997;69:179–190
- . Immunocytochemical localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci. 1999;11:946–958
- . Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. J Physiol. 2001;543.2:437–445
- . The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br J Pharmacol. 1999;126:326–332
- . Sympathetic nervous system: contribution to chronic pain. Brain Res. 2000;129:451–468
- . Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain. Expert Opin Ther Targets. 2003;7:513–522
- . Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat. Exp Brain Res. 2002;147:511–519
- . Crossing the pain barrier: P2 receptors as targets for novel analgesics. J Physiol. 2003;553.3:683–694
- . P2X receptors: targets for novel analgesics?. Neuroscientist. 2005;11:345–356
- . Peripheral nociceptive effects of α2-adrenergic receptor agonists in the rat. Neuroscience. 1995;66:427–432
- . Epinephrine produces a β-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol. 1999;81:1104–1112
- . Changes in the gene expression of six subtypes of P2X receptors in rat dorsal root ganglion after spinal nerve ligation. Neurosci Lett. 2003;337:81–84
- . Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat. Neuroscience. 1995;65:283–291
- . Recent advances in α1-adrenoceptor pharmacology. Pharmacol Therapeutic. 2003;98:235–244
- . Receptor subtype mediating the adrenergic sensitivity of pain behavior and ectopic discharges in neuropathic Lewis rats. J Neurophysiol. 1999;81:2226–2233
- . Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors. Nature. 1986;323:158–160
- . Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J Neurosci. 1993;13:2136–2148
- . Sympathetic modulation of acute cutaneous flare induced by intradermal injection of capsaicin in anesthetized rats. J Neurophysiol. 2003;89:853–861
- . Modulation of P2X receptors via adrenergic pathways in rat dorsal root ganglion neurons after sciatic nerve injury. Pain. 2006;120:106–112
- . Antinociceptive properties of a selective non-nucleotide P2X3/P2X2/3 receptor antagonist. Drug News Perspect. 2005;19:501–507
- . Adrenergic sensitivity of the rat sensory receptors modulating mechanical allodynia in a rat neuropathic pain model. Pain. 1999;80:589–595
- . The P2X3 subunit: A molecular target in pain therapeutics. Curr Opin Investig Drugs. 2003;4:833–840
- . Alpha 1-adrenoceptor-mediated sympathetically dependent mechanical hyperalgesia in the rat. Eur J Pharmacol. 1995;273:107–112
- . Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy. Pain. 2000;87:171–179
- . Inflammatory mediators potentiate ATP-gated channels through the P2X3 subunit. J Biol Chem. 2001;276:21077–21082
- . Distribution of alpha-1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype specific probes. J Neurosci. 1994;14:4252–4268
- . Induction of vanilloid receptor channel activity by protein kinase C. Nature. 2000;408:985–990
- . Nerve growth factor induced P2X3 expression in sensory neurons. J Neurochem. 2001;77:864–875
- . Sympathetic modulation of activity in Aδ- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats. J Neurophysiol. 2005;93:365–377
- . Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science. 1991;251:1608–1610
- . Distribution and regulation of α2-adrenoceptors in rat dorsal root ganglia. Pain. 2000;84:319–330
- . Alpha-1 adrenoceptor hyperresponsiveness in three neuropathic pain states: Complex regional pain syndrome, diabetic peripheral neuropathic pain and central pain states after spinal cord injury. Pain Res Manage. 2004;9:89–97
- . Peripheral hyperalgesia in experimental neuropathy: Mediation by α2-adrenoreceptors on post-ganglionic sympathetic terminals. Pain. 1995;60:317–327
- . Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: Involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons. J Neurosci. 2000;20:1–5RC90
- . Differential regulation of P2X3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia. Pain. 2001;91:351–360
- . Receptor-mediated stimulation and inhibition of nerve growth factor secretion by vascular smooth muscle. Exp Cell Res. 1993;208:350–361
- . Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol. 2001;534:813–825
- . Peripheral P2X receptors and nociception: Interactions with biogenic amine systems. Pain. 2004;110:79–89
- . Differential expression of alpha1-adrenergic subtype mRNAs in the dorsal root ganglion after spinal nerve ligation. Mol Brain Res. 2001;93:164–172
- . Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons. J Neurosci. 2002;22:93–102
- . Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors. Proc Natl Acad Sci U S A. 2004;101:11868–11873
- . Development of purinergic sensitivity in sensory neurons after peripheral nerve injury in the rat. Brain Res. 2001;915:161–169
Supported by the Canadian Institutes of Health Research.
PII: S1526-5900(07)00638-4
doi: 10.1016/j.jpain.2007.02.434
© 2007 American Pain Society. Published by Elsevier Inc. All rights reserved.
« Previous
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The Journal of Pain
Volume 8, Issue 7
, Pages 556-562
, July 2007
