The Journal of Pain
Volume 10, Issue 2 , Pages 208-213 , February 2009

A Single-Blind, Placebo Run-in Study of Duloxetine for Activity-Limiting Osteoarthritis Pain

  • Mark D. Sullivan

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Division of Consultation-Liaison Psychiatry, University of Washington, Seattle
    • Corresponding Author InformationAddress reprint requests to Dr Mark Sullivan, Department of Psychiatry and Behavioral Sciences, Box 356560, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195-6560
    • ,
  • Susan Bentley

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Division of Consultation-Liaison Psychiatry, University of Washington, Seattle
    • ,
  • Ming-Yu Fan

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Division of Consultation-Liaison Psychiatry, University of Washington, Seattle
    • ,
  • Greg Gardner

      Affiliations

    • Department of Medicine, Division of Rheumatology, University of Washington, Seattle

Received 15 April 2008 ,Revised 19 August 2008 ,Accepted 29 August 2008.

References 

  1. Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA. Use of nonsteroidal antiinflammatory drugs: an update for clinicians: A scientific statement from the American Heart Association. Circulation. 2007;115:1634–1642
  2. Atkinson JH, Slater MA, Wahlgren DR, Williams RA, Zisook S, Pruitt SD, et al. Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity. Pain. 1999;83:137–145
  3. Atkinson JH, Slater MA, Williams RA, Zisook S, Patterson TL, Grant I, et al. A placebo-controlled randomized clinical trial of nortriptyline for chronic low back pain. Pain. 1998;76:287–296
  4. Caldwell JR, Hale ME, Boyd RE, Hague JM, Iwan T, Shi M, et al. Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: A double blind, randomized, multicenter, placebo controlled trial. J Rheumatol. 1999;26:862–869
  5. Daut RL, Cleeland CS, Flanery RC. Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases. Pain. 1983;17:197–210
  6. Doak W, Hosie J, Hossain M, James I, Reid I, Miller A. A novel combination of ibuprofen and codeine phosphate in the treatment of osteoarthritis: A double-blind placebo controlled study. J Drug Dev. 1992;4:179–187
  7. Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, et al. Osteoarthritis: New insights, I: The disease and its risk factors. Ann Intern Med. 2000;133:635–646
  8. Fishbain DA, Cutler RB, Rosomoff HL, Rosomoff RS. Do antidepressants have an analgesic effect in psychogenic pain and somatoform pain disorder? (A meta-analysis). Psychosom Med. 1998;60:503–509
  9. Goldstein DJ, Lu Y, Detke MJ, Lee TC, Iyengar S. Duloxetine vs. placebo in patients with painful diabetic neuropathy. Pain. 2005;116(1-2):109–118
  10. Jackson JL, O'Malley PG, Tomkins G, Balden E, Santoro J, Kroenke K. Treatment of functional gastrointestinal disorders with antidepressant medications: A meta-analysis. Am J Med. 2000;108:65–72
  11. Jensen E, Ginsberg F. Tramadol versus dextropopoxyphene in the treatment of osteoarthritis: A short term double-blind study. Drug Invest. 1994;8:211–218
  12. Kjaersgaard-Andersen P, Nafei A, Skov O, Madsen F, Andersen HM, Kroner K, et al. Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip: A randomised, double-blind, multi-centre study. Pain. 1990;43:309–318
  13. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–613
  14. Lin EH, Katon W, Von Korff M, Tang L, Williams JW, Kroenke K, et al. Effect of improving depression care on pain and functional outcomes among older adults with arthritis: A randomized controlled trial. JAMA. 2003;290:2428–2429
  15. McQuay HJ, Tramer M, Nye BA, Carroll D, Wiffen PJ, Moore RA. A systematic review of antidepressants in neuropathic pain. Pain. 1996;68(2-3):217–227
  16. Moore RA, Derry S, McQuay HJ. Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: Balancing gastrointestinal and cardiovascular risk. BMC Musculoskel Disord. 2007;8:73
  17. O'Malley PG, Balden E, Tomkins G, Santoro J, Kroenke K, Jackson JL. Treatment of fibromyalgia with antidepressants: A meta-analysis. J Gen Intern Med. 2000;15:659–666
  18. Peloso PM, Bellamy N, Bensen W, Thomson GT, Harsanyi Z, Babul N, et al. Double blind randomized placebo control trial of controlled release codeine in the treatment of osteoarthritis of the hip or knee. J Rheumatol. 2000;27:764–771
  19. Prevalence of self-reported arthritis or chronic joint symptoms among adults–United States, 2001. MMWR Morb Mortal Wkly Rep. 2002;51:948–950
  20. Quiding H, Grimstad J, Rusten K, Stubhaug A, Bremnes J, Breivik H. Ibuprofen plus codeine, ibuprofen, and placebo in a single- and multidose cross-over comparison for coxarthrosis pain. Pain. 1992;50:303–307
  21. Roth SH, Fleischmann RM, Burch FX, Dietz F, Bockow B, Rapoport RJ, et al. Around-the-clock, controlled-release oxycodone therapy for osteoarthritis-related pain: Placebo-controlled trial and long-term evaluation. Arch Intern Med. 2000;160:853–860
  22. Salerno SM, Browning R, Jackson JL. The effect of antidepressant treatment on chronic back pain: a meta-analysis. Arch Intern Med. 2002;162:19–24
  23. Sindrup SH, Bach FW, Madsen C, Gram LF, Jensen TS. Venlafaxine versus imipramine in painful polyneuropathy: A randomized, controlled trial. Neurology. 2003;60:1284–1289
  24. Sullivan M, Katon W, Russo J, Dobie R, Sakai C. A randomized trial of nortriptyline for severe chronic tinnitus: Effects on depression, disability, and tinnitus symptoms. Arch Intern Med. 1993;153:2251–2259
  25. Tomkins GE, Jackson JL, O'Malley PG, Balden E, Santoro JE. Treatment of chronic headache with antidepressants: A meta-analysis. Am J Med. 2001;111:54–63
  26. Unutzer J, Katon W, Callahan CM, Williams JW, Hunkeler E, Harpole L, et al. Collaborative care management of late-life depression in the primary care setting: A randomized controlled trial. JAMA. 2002;288:2836–2845
  27. Whitehouse SL, Lingard EA, Katz JN, Learmonth ID. Development and testing of a reduced WOMAC function scale. J Bone Joint Surg Br. 2003;85:706–711

 Supported by an investigator-initiated research grant from Eli Lilly to Mark D. Sullivan.

PII: S1526-5900(08)00736-0

doi: 10.1016/j.jpain.2008.08.009

The Journal of Pain
Volume 10, Issue 2 , Pages 208-213 , February 2009

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