The Journal of Pain
Volume 10, Issue 3 , Pages 316-322 , March 2009

Hyperalgesia in Opioid-Managed Chronic Pain and Opioid-Dependent Patients

  • Justin L. Hay

      Affiliations

    • Discipline of Pharmacology, Medical School North, University of Adelaide, SA, Australia
    • Corresponding Author InformationAddress reprint requests to Dr Justin Hay, CHDR, Zernikedreef 10, 2333 CL Leiden, The Netherlands.
  • ,
  • Jason M. White

      Affiliations

    • Discipline of Pharmacology, Medical School North, University of Adelaide, SA, Australia
    • Drug and Alcohol Services South Australia, Parkside, SA, Australia
  • ,
  • Felix Bochner

      Affiliations

    • Discipline of Pharmacology, Medical School North, University of Adelaide, SA, Australia
    • Department of Clinical Pharmacology, Royal Adelaide Hospital, Adelaide, SA, Australia
  • ,
  • Andrew A. Somogyi

      Affiliations

    • Discipline of Pharmacology, Medical School North, University of Adelaide, SA, Australia
    • Department of Clinical Pharmacology, Royal Adelaide Hospital, Adelaide, SA, Australia
  • ,
  • Tim J. Semple

      Affiliations

    • Pain Management Unit, Royal Adelaide Hospital, Adelaide, SA, Australia
  • ,
  • Bruce Rounsefell

      Affiliations

    • Pain Management Unit, Royal Adelaide Hospital, Adelaide, SA, Australia

Received 28 March 2008 ,Revised 15 September 2008 ,Accepted 7 October 2008.

References 

  1. Ali NM. Hyperalgesic response in a patient receiving high concentrations of spinal morphine. Anesthesiology. 1986;65:449
  2. Angst MS, Clark JD. Opioid-induced hyperalgesia: A qualitative systematic review. Anesthesiology. 2006;104:570–587
  3. Aronson MD. Nonsteroidal anti-inflammatory drugs, traditional opioids, and tramadol: Contrasting therapies for the treatment of chronic pain. Clin Ther. 1997;19:420–432
  4. Aubrun F, Langeron O, Quesnel C, Coriat P, Riou B. Relationships between measurement of pain using visual analog score and morphine requirements during postoperative intravenous morphine titration. Anesthesiology. 2003;98:1415–1421
  5. Ayonrinde OT, Bridge DT. The rediscovery of methadone for cancer pain management. Med J Aust. 2000;173:536–540
  6. Beaver WT, Wallenstein SL, Houde RW, Rogers A. A clinical comparison of the analgesic effects of methadone and morphine administered intramuscularly, and of orally and parenterally administered methadone. Clin Pharmacol Ther. 1967;8:415–426
  7. Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain. 2000;123(Pt 8):1703–1709
  8. Chen AC, Dworkin SF, Haug J, Gehrig J. Human pain responsivity in a tonic pain model: Psychological determinants. Pain. 1989;37:143–160
  9. Chu LF, Clark DJ, Angst MS. Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: A preliminary prospective study. J Pain. 2006;7:43–48
  10. Cohen MJ, Naliboff BD, Schandler SL, Heinrich RL. Signal detection and threshold measures to loud tones and radiant heat in chronic low back pain patients and cohort controls. Pain. 1983;16:245–252
  11. Compton MA. Cold-pressor pain tolerance in opiate and cocaine abusers: Correlates of drug type and use status. J Pain Symptom Manage. 1994;9:462–473
  12. Compton P, Charuvastra VC, Ling W. Pain intolerance in opioid-maintained former opiate addicts: Effect of long-acting maintenance agent. Drug Alcohol Depend. 2001;63:139–146
  13. De Conno F, Caraceni A, Martini C, Spoldi E, Salvetti M, Ventafridda V. Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine. Pain. 1991;47:337–339
  14. Dole VP, Nyswander M. A medical treatment for diacetylmorphine (heroin) addiction. JAMA. 1965;193:80–84
  15. Doverty M, White JM, Somogyi AA, Bochner F, Ali R, Ling W. Hyperalgesic responses in methadone maintenance patients. Pain. 2001;90:91–96
  16. Eccleston C, Crombez G. Pain demands attention: A cognitive-affective model of the interruptive function of pain. Psychol Bull. 1999;125:356–366
  17. Fillingim RB, Doleys DM, Edwards RR, Lowery D. Clinical characteristics of chronic back pain as a function of gender and oral opioid use. Spine. 2003;28:143–150
  18. Fishbain DA, Rosomoff HL, Rosomoff RS. Drug abuse, dependence, and addiction in chronic pain patients. Clin J Pain. 1992;8:77–85
  19. Handelsman L, Cochrane KJ, Aronson MJ, Ness R, Rubinstein KJ, Kanof PD. Two new rating scales for opiate withdrawal. Am J Drug Alcohol Abuse. 1987;13:293–308
  20. Ho A, Dole VP. Pain perception in drug-free and in methadone-maintained human ex-addicts. Proc Soc Exp Biol Med. 1979;162:392–395
  21. Jensen TS, Gottrup H, Sindrup SH, Bach FW. The clinical picture of neuropathic pain. Eur J Pharmacol. 2001;429:1–11
  22. Li X, Angst MS, Clark JD. Opioid-induced hyperalgesia and incisional pain. Anesth Analg. 2001;93:204–209
  23. Li X, Angst MS, Clark JD. A murine model of opioid-induced hyperalgesia. Brain Res Mol Brain Res. 2001;86:56–62
  24. Li X, Clark JD. Hyperalgesia during opioid abstinence: Mediation by glutamate and substance p. Anesth Analg. 2002;95:979–984
  25. Ling W, Cunningham-Rathner J, Fradis J, Torrington M, Keating M, White J. Opioid-induced hyperalgesia: Effects of buprenorphine treatment. Presented at the Meeting of the College on Problems of Drug Dependence, Miami, FL. 2003
  26. Mao J, Price DD, Mayer DJ. Thermal hyperalgesia in association with the development of morphine tolerance in rats: Roles of excitatory amino acid receptors and protein kinase C. J Neurosci. 1994;14:2301–2312
  27. Mao J, Sung B, Ji RR, Lim G. Chronic morphine induces downregulation of spinal glutamate transporters: Implications in morphine tolerance and abnormal pain sensitivity. J Neurosci. 2002;22:8312–8323
  28. Martin JE, Inglis J. Pain tolerance and narcotic addiction. Br J Soc Clin Psychol. 1965;4:224–229
  29. Martin WR, Jasinski DR, Haertzen CA, Kay DC, Jones BE, Mansky PA, et al. Methadone: A reevaluation. Arch Gen Psychiatry. 1973;28:286–295
  30. Merskey H, Bogduk N. Classification of Chronic Pain: IASP Task Force on Taxonomy. Seattle, WA: IASP Press; 1994;209–214
  31. Mitchell TB, White JM, Somogyi AA, Bochner F. Switching between methadone and morphine for maintenance treatment of opioid dependence: Impact on pain sensitivity and mood status. Am J Addict. 2006;15:311–315
  32. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649–655
  33. Parkinson SK, Bailey SL, Little WL, Mueller JB. Myoclonic seizure activity with chronic high-dose spinal opioid administration. Anesthesiology. 1990;72:743–745
  34. Potter JM, Reid DB, Shaw RJ, Hackett P, Hickman PE. Myoclonus associated with treatment with high doses of morphine: The role of supplemental drugs. BMJ. 1989;299:150–153
  35. Pud D, Cohen D, Lawental E, Eisenberg E. Opioids and abnormal pain perception: New evidence from a study of chronic opioid addicts and healthy subjects. Drug Alcohol Depend. 2006;82:218–223
  36. Reznikov I, Pud D, Eisenberg E. Oral opioid administration and hyperalgesia in patients with cancer or chronic nonmalignant pain. Br J Clin Pharmacol. 2005;60:311–318
  37. Schmidt AJ, Brands AM. Persistence behavior of chronic low back pain patients in an acute pain situation. J Psychosom Res. 1986;30:339–346
  38. Sjøgren P, Jonsson T, Jensen NH, Drenck NE, Jensen TS. Hyperalgesia and myoclonus in terminal cancer patients treated with continuous intravenous morphine. Pain. 1993;55:93–97
  39. Toombs JD, Kral LA. Methadone treatment for pain states. Am Fam Physician. 2005;71:1353–1358
  40. van Damme S, Crombez G, Eccleston C, Koster EH. Hypervigilance to learned pain signals: A componential analysis. J Pain. 2006;7:346–357
  41. Vanderah TW, Gardell LR, Burgess SE, Ibrahim M, Dogrul A, Zhong CM, et al. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. J Neurosci. 2000;20:7074–7079
  42. Vanderah TW, Suenaga NM, Ossipov MH, Malan TP, Lai J, Porreca F. Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. J Neurosci. 2001;21:279–286
  43. Walsh NE, Schoenfeld L, Ramamurthy S, Hoffman J. Normative model for cold pressor test. Am J Phys Med Rehabil. 1989;68:6–11
  44. Wesson D, Ling W, Jara G. Buprenorphine in pharmacotherapy of opioid addiction: Implementation in office-based medical practice. Translating the Experience of Clinical Trials into Clinical Practice. San Francisco, CA: California Society of Addiction Medicine; 1999;
  45. Wesson DR, Ling W. The Clinical Opiate Withdrawal Scale (COWS). J Psychoactive Drugs. 2003;35:253–259
  46. White JM. Pleasure into pain: The consequences of long-term opioid use. Addict Behav. 2004;29:1311–1324
  47. Woolf CJ. Intrathecal high dose morphine produces hyperalgesia in the rat. Brain Res. 1981;209:491–495

 Supported in part by the Faculty of Health Science Small Research Grant Scheme. Justin Hay was a recipient of a University of Adelaide Postgraduate scholarship. Presented in part at the 11th World Congress on Pain (IASP), August 2005, Sydney, Australia.

PII: S1526-5900(08)00801-8

doi: 10.1016/j.jpain.2008.10.003

The Journal of Pain
Volume 10, Issue 3 , Pages 316-322 , March 2009