The Journal of Pain
Volume 10, Issue 4 , Pages 416-425 , April 2009

Peripheral Nerve Pathways of Afferent Fibers Innervating the Lumbar Spine in Rats

  • Yuzuru Takahashi

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Dr Yuzuru Takahashi, Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
    • ,
  • Seiji Ohtori
    • ,
  • Kazuhisa Takahashi

Received 22 June 2008 ,Revised 13 October 2008 ,Accepted 16 October 2008.

References 

  1. Anderson JE. Grant's Atlas of Anatomy. 8th ed.. Baltimore/London: Williams & Wilkins; 1983;
  2. Ashton IK, Roberts S, Jaffray DC, Polak JM, Eisenstein SM. Neuropeptides in the human intervertebral disc. J Orthop Res. 1994;12:186–192
  3. Bogduk N. Nerves of the lumbar spine. In:  Bogduk N editors. Clinical Anatomy of the Lumbar Spine and Sacrum. New York/Edinburgh/London/Madrid/Melbourne/San Francisco/Tokyo: Churchill Livingstone; 1997;p. 143
  4. Bogduk N. The innervation of the lumbar spine. Spine. 1983;8:286–293
  5. Bogduk N, Tynan W, Wilson AS. The nerve supply to the human lumbar intervertebral discs. J Anat. 1981;132:39–56
  6. Green EC. Anatomy of the Rated. Philadelphia: Hafner Publishing Co; 1963;
  7. Groen GJ, Baljet B, Drukker J. Nerves and nerve plexuses of the human vertebral column. Am J Anat. 1990;188:282–296
  8. Higuchi K, Sato T. Anatomical study of lumbar spine innervation. Folia Morphol. 2002;61:71–79
  9. Honig MG, Hume RI. DiI and DiO: Versatile fluorescent dyes for neuronal labelling and pathway tracing. Trend Neurosci. 1989;12:333–341
  10. Honig MG, Hume RI. Fluorescent carbocyanine dyes allow living neurons of identified origin to be studied in long-term cultures. J Cell Biol. 1986;103:171–187
  11. Jinkins JR, Wittemore AR, Bradley WG. The anatomic basis of vertebrogenic pain and the autonomic syndrome associated with lumbar disc extrusion. Am J Radiol. 1989;152:1277–1289
  12. Kojima Y, Maeda T, Arai R, Shichikawa K. Nerve supply to the posterior longitudinal ligament and the intervertebral disc of the rat vertebral column as studied by acetylcholinesterase histochemistry, I: Distribution in the lumbar region. J Anat. 1990;169:237–246
  13. Kojima Y, Maeda T, Arai R, Shichikawa K. Nerve supply to the posterior longitudinal ligament and the intervertebral disc of the rat vertebral column as studied by acetylcholinesterase histochemistry, II: Regional differences in the distribution of the nerve fibres and their origins. J Anat. 1990;169:247–255
  14. McCarthy PW, Carruthers B, Martin D, Petts P. Immunohistochemical demonstration of sensory nerve fibers and endings in lumbar intervertebral discs of the rat. Spine. 1991;16:653–655
  15. Miller MR, Kasahara M. Observations on the innervation of human long bones. Anat Rec. 1963;145:13–22
  16. Murata Y, Takahashi K, Yamagata M, Takahashi Y, Shimada Y, Moriya H. Sensory innervation of the sacroiliac joint in rats. Spine. 2000;25:2015–2019
  17. Nakamura S, Takahashi K, Takahashi Y, Morinaga T, Shimada Y, Moriya H. Origin of nerves supplying the posterior portion of lumbar intervertebral discs in rats. Spine. 1996;21:917–924
  18. Nakamura S, Takahashi K, Takahashi Y, Yamagata M, Moriya H. The afferent pathways of discogenic low-back pain: Evaluation of L2 spinal nerve infiltration. J Bone Joint Surg (Br). 1996;78-B:606–612
  19. Netter FH. Atlas of Human Anatomy (Japanese Edition). 2nd ed.. Tokyo: Maruzen; 2001;
  20. Ohtori S, Takahashi Y, Takahashi K, Chiba T, Tanaka K, Hirayama J, et al. Sensory innervation of the dorsal portion of the lumbar intervertebral disc in rats. Spine. 1999;24:2295–2299
  21. Palmgren T, Gronblad M, Viri J, Kaapa E, Karaharju E. An immunohistochemical study of nerve structures in the anulus fibrosus of human normal lumbar intervertebral discs. Spine. 1999;24:2075–2079
  22. Pedersen HE, Blunck CFJ, Gardner E. The anatomy of lumbosacral posterior rami and meningeal branches of spinal nerves (Sinu-vertebral nerves). J Bone Joint Surg (Am). 1956;38-A:377–391
  23. Raoul S, Faure A, Robert R, Rogez J-M, Hamel O, Cuillere P, et al. Role of the sinu-vertebral nerve in low back pain and anatomical basis of the therapeutic implications. Surg Radiol Anat. 2002;24:366–371
  24. Sekiguchi Y, Konnai Y, Kikuchi S, Sugiura Y. An anatomic study of neuropeptide immunoreactivities in the lumbar dura mater after lumbar sympathectomy. Spine. 1996;21:925–930
  25. Suseki K, Takahashi Y, Takahashi K, Chiba T, Tanaka K, Moriya H. CGRP-immunoreactive nerve fibers projecting to lumbar facet joints through the paravertebral sympathetic trunk in rats. Neurosci Lett. 1996;221:41–44
  26. Suseki K, Takahashi Y, Takahashi K, Chiba T, Tanaka K, Nakamura S, et al. Innervation of the lumbar facet joints in rats. Rinsho Seikeigeka. 1996;31:503–508
  27. Suseki K, Takahashi Y, Takahashi K, Chiba T, Yamagata M, Moriya H. Sensory nerve fibres from lumbar intervertebral discs pass through rami communicantes: A possible pathway for discogenic low back pain. J Bone Joint Surg (Br). 1998;80-B:737–742
  28. Takahashi Y, Chiba T, Kurokawa M, Aoki Y, Takahashi K, Yamagata M. Stereoscopic structure of sensory nerve fibers in the lumbar spine and related tissues. Spine. 2003;28:871–880
  29. Takahashi Y, Nakajima Y, Sakamoto T, Takahashi K, Moriya H. Capsaicin applied to rat lumbar intervertebral disc causes extravasation in the groin skin: A possible mechanism of referred pain of the lumbar intervertebral disc. Neurosci Lett. 1993;161:1–3
  30. Takebayashi T, Cavanaugh JM, Kallakuri S, Chen C, Yamashita T. Sympathetic afferent units from lumbar intervertebral discs. J Bone Joint Surg (Br). 2006;88-B:554–557
  31. Thurston TJ. Distribution of nerves in long bones as shown by silver impregnation. J Anat. 1982;134:719–728
  32. Wiberg G. Back pain in relation to the nerve supply of the intervertebral disc. Acta Orthop. 1949;19:212–221
  33. Yamashita T, Minaki Y, Oota I, Yokogushi K, Ishii S. Mechanosensitive afferent units in the lumbar intervertebral disc and adjacent muscle. Spine. 1993;18:2252–2256

 Supported by a grant-in-aid (18689037) for Scientific Research from the Japan Society for the Promotion of Science.

PII: S1526-5900(08)00854-7

doi: 10.1016/j.jpain.2008.10.012

The Journal of Pain
Volume 10, Issue 4 , Pages 416-425 , April 2009

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