The Journal of Pain
Volume 11, Issue 1 , Pages 24-31 , January 2010

A Multicenter, Open-Label, Exploratory Dose-Ranging Trial of Intranasal Hydromorphone for Managing Acute Pain from Traumatic Injury

  • Daniel P. Wermeling

      Affiliations

    • Department of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky College of Pharmacy, Lexington, Kentucky
    • Corresponding Author InformationAddress reprint requests to Dr. Daniel Wermeling, Associate Professor, University of Kentucky College of Pharmacy, 725 Rose Street, Lexington, KY 40536-0082.
    • ,
  • Thomas Clinch

      Affiliations

    • Intranasal Therapeutics, Inc., Lexington, Kentucky
    • ,
  • Anita C. Rudy

      Affiliations

    • Intranasal Therapeutics, Inc., Lexington, Kentucky
    • ,
  • David Dreitlein

      Affiliations

    • Department of Emergency Medicine, Montrose Memorial Hospital, Montrose, Colorado
    • ,
  • Selim Suner

      Affiliations

    • Associate Professor of Emergency Medicine, Surgery, and Engineering, Brown University, Providence, Rhode Island
    • Director of Emergency Preparedness and Disaster Medicine, Department of Emergency Medicine, Rhode Island Hospital, Providence, Rhode Island
    • ,
  • Peter G. Lacouture

      Affiliations

    • Magidom Discovery, Tampa, Florida

Received 5 February 2009 ,Revised 23 April 2009 ,Accepted 22 May 2009.

References 

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  2. Bhargava R, Young KD. Procedural pain management patterns in academic pediatric emergency departments. Acad Emerg Med. 2007;14:479–482
  3. Brown JC, Klein EJ, Lewis CW. Emergency department analgesia for fracture pain. Ann Emerg Med. 2003;42:197–205
  4. Chang AK, Bijur PE, Meyer RH. Safety and efficacy of hydromorphone as an analgesic alternative to morphine in acute pain: A randomized clinical trial. Ann Emerg Med. 2006;48:164–172
  5. Coda BA, Rudy AC, Wermeling DP. Pharmacokinetics and Bioavailability of Single-Dose Intranasal Hydromorphone Hydrochloride in Healthy Volunteers. Anesth Analg. 2003;97:117–123
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  12. Rudy AC, Coda BA, Wermeling DP. A Multiple Dose Phase 1 Study of Intranasal Hydromorphone Hydrochloride in Healthy Volunteers. Anesth Analg. 2004;99:1379–1386
  13. Thomas T. Providing pain relief for patients in the emergency department. Nursing Standard. 2007;9:41–45
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  15. Walter DJ, Zacny JP. Subjective, Psychomotor and Physiological Effects of Cumulative Doses of Opioid Mu Agonists in Health Volunteers. J Pharmacol Expl Therap. 1999;289:1454–1464

 The multicenter study was supported by grants from Intranasal Therapeutics, Inc. The following information is provided as a statement of potential conflicts of interest. Drs. Wermeling and Lacouture were paid consultants to Intranasal Therapeutics, Inc., at the time of this research. Drs. Wermeling and Rudy and Mr. Clinch own stock options in Intranasal Therapeutics. Drs. Lacouture, Dreitlein and Suner have no conflicts to disclose.

PII: S1526-5900(09)00547-1

doi: 10.1016/j.jpain.2009.05.002

The Journal of Pain
Volume 11, Issue 1 , Pages 24-31 , January 2010

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