The Journal of Pain
Volume 11, Issue 2 , Pages 149-159 , February 2010

A Prolonged Protein Kinase C-Mediated, Opioid-Related Antinociceptive Effect of St John's Wort in Mice

  • Nicoletta Galeotti

      Affiliations

    • Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G. Pieraccini 6, I-50 139 Florence, Italy
    • Corresponding Author InformationAddress reprint requests to: Dr. Nicoletta Galeotti, Dept. of Pharmacology, Viale G. Pieraccini 6, I-50139 Florence, Italy.
    • ,
  • Elisa Vivoli

      Affiliations

    • Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G. Pieraccini 6, I-50 139 Florence, Italy
    • ,
  • Anna Rita Bilia

      Affiliations

    • Department of Pharmaceutical Sciences, University of Florence, via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy
    • ,
  • Maria Camilla Bergonzi

      Affiliations

    • Department of Pharmaceutical Sciences, University of Florence, via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy
    • ,
  • Alessandro Bartolini

      Affiliations

    • Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G. Pieraccini 6, I-50 139 Florence, Italy
    • ,
  • Carla Ghelardini

      Affiliations

    • Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G. Pieraccini 6, I-50 139 Florence, Italy

Received 10 February 2009 ,Revised 18 May 2009 ,Accepted 24 June 2009.

References 

  1. Agostinis P, Vantieghem A, Merlevede W, de Witte PA. Hypericin in cancer treatment: More light on the way. Int J Biochem Cell Biol. 2002;34:221–241
  2. Barnes J, Anderwson LA, Phillipson DJ. St. John's wort (Hypericum perforatum L.): A review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2001;53:583–600
  3. Bergonzi MC, Bilia AR, Gallori S, Guerrini D, Vincieri FF. Variability in the content of the constituents of Hypericum perforatum L. and some commercial extracts. Drug Dev Ind Pharm. 2001;27:491–497
  4. Bighetti EJB, Hiruma-Lima CA, Gracioso JS, Souza Brito ARM. Anti-inflammatory and antinociceptive effects in rodents of the essential oil of Croton cajucara Benth. J Pharm Pharmacol. 1999;51:1447–1453
  5. Bilia AR, Gallori S, Vincieri FF. St. John's wort and depression: Efficacy, safety and tolerability – an update. Life Sci. 2002;70:3077–3096
  6. Bombardelli E, Morazzoni P. Hypericum perforatum. Fitoterapia. 1995;66:43–68
  7. Brolis M, Gabetta B, Fuzzati N, Pace R, Panzeri F, Peterlongo F. Identification by high performance liquid chromatography-diode array detection-mass spectrometry and quantification by high performance liquid chromatography-UV absorbance detection of active constituents of Hypericum perforatum. J Chromatogr A. 1998;825:9–16
  8. Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Muller WE. Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci. 1998;63:499–510
  9. Chatterjee SS, Noldner M, Koch E, Erdelmeier C. Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility. Pharmacopsychiatry. 1998;31(Suppl 1):7–15
  10. Collier HOJ, Dinneen LC, Johnson CA, Schnider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol. 1968;32:295–310
  11. Ferriola PC, Cody V, Middleton E. Protein kinase C inhibition by plant flavonoids. Biochem Pharmacol. 1989;38:1617–1624
  12. Fiebich BL, Hollig A, Lieb K. Inhibition of substance P-induced cytokine synthesis by St. John's Wort extracts. Pharmacopsychiatry. 2001;34(Suppl 1):S26–S28
  13. Galeotti N, Bartolini A, Ghelardini C. The phospholipase C-IP3 pathway is involved in muscarinic antinociception. Neuropsychopharmacology. 2003;28:888–897
  14. Gobbi M, Dalla Valle F, Ciapparelli C, Diomede L, Morazzoni P, Verotta L, et al. Hypericum perforatum L. extract does not inhibit 5-HT transporter in the rat brain. N.-S Arch Pharmacol. 1999;360:262–269
  15. Greeson JM, Sanford B, Monti DA. St, John's wort (Hypericum perforatum): A review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology. 2001;153:402–414
  16. Gulya K, Krivan M, Nyolczas N, Sarnyai Z, Kovacs GL. Central effects of the potent and highly selective μ opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice. Eur J Pharmacol. 1988;150:355–360
  17. Hammer K, Hillwig ML, Solco AK, Dixon PM, Delate K, Murphy PA, et al. Inhibition of prostaglandin E2 production by anti-inflammatory Hypericum perforatum extracts in RAW264.7 mouse macrophage cells. J Agric Food Chem. 2007;55:7323–7331
  18. Horan P, Taylor J, Yamamura HI, Porreca F. Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail flick test. J Pharmacol Exp Ther. 1992;260:1237–1243
  19. Isacchi B, Galeotti N, Bergonzi MC, Ghelardini C, Bilia AR, Vincieri FF. Pharmacological in vivo test to evaluate the bioavailability of some St. John's Wort innovative oral preparations. Phytother Res. 2009;23:197–205
  20. Kubin A, Wierrani F, Burner U, Alth G, Grünberger W. Hypericin – The facts about a controversial agent. Curr Pharmac Des. 2005;11:233–253
  21. Linde K, Mulrow CD, Berner M, Egger M: St John's wort for depression. Cochrane Database Syst Rev 2:CD000448, 2005
  22. Mattace Raso G, Pacilio M, Di Carlo G, Esposito E, Pinto L, Meli R. In-vivo and in-vitro anti-inflammatory effect of Echinacea purpurea and Hypericum perforatum. J Pharm Pharmacol. 2002;54:1379–1383
  23. Medina MA, Martínez-Poveda B, Amores-Sánchez MI, Quesada AR. Hyperforin: More than an antidepressant bioactive compound?. Life Sci. 2006;79:105–111
  24. Meotti FC, Luiz AP, Pizzolatti MG, Kassuya CAL, Calixto JB, Santos AR. Analysis of the antinociceptive effect of the flavonoid myricitrin: Evidence for a role of the L-arginine nitric-oxide and protein kinase C pathways. J Pharmacol Exp Ther. 2006;316:789–796
  25. Muller WE, Singer E, Wonnemann M, Hafner U, Rolli M, Schafer C. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry. 1998;31(Suppl 1):16–21
  26. Portoghese PS, Sultana M, Nagase H, Takemori AE. A highly selective δ1-opiod receptor antagonist: 7-benzylidenenaltrexone. Eur J Pharmacol. 1992;218:195–196
  27. Simmen U, Higelin J, Berger-Büter K, Schaffner W, Lundstrom K. Neurochemical studies with St. John's Wort in vitro. Pharmacopsychiatry. 2001;34(Suppl 1):S137–S142
  28. Simmen U, Schweitzer C, Burkard W, Schaffner W, Lundstrom K. Hypericum perforatum inhibits the binding of mu- and kappa-opioid receptor expressed with the Semliki Forest virus system. Pharm Acta Helv. 1998;73:53–56
  29. Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of δ opioid agonists by naltrindone and its benzofuran analog (NTB) in mice. Evidence for δ opioid receptor subtypes. J Pharmacol Exp Ther. 1991;257:676–680
  30. Sosa S, Pace R, Bornancin A, Morazzoni P, Riva A, Tubaro A, et al. Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. J Pharm Pharmacol. 2007;59:703–709
  31. Srinivasan K, Muruganandan S, Lal J, Chandra S, Tandan SK, Raviprakash V, et al. Antinociceptive and antipyretic activities of Pongamia pinnata leaves. Phytother Res. 2003;17:259–264
  32. Suzuki O, Katsumata Y, Oya M, Bladt S, Wagner H. Inhibition of monoamine oxidase by hypericin. Planta Med. 1984;50:272–274
  33. Takahashi I, Nakanishi S, Kobayashi E, Nakano H, Suzuki K, Tamaoki T. Hypericin and pseudohypericin specifically inhibit protein kinase C: Possible relation to their antiretroviral activity. Biochem Biophys Res Commun. 1989;165:1207–1212
  34. Tedeschi E, Menegazi M, Margotto D, Suzuki H, Forstermann U, Kleinert H. Antiinflammatory actions of St. John's wort: Inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1 alpha) activation. J Pharmacol Exp Ther. 2003;307:54–261
  35. Uchida S, Hirai K, Hatanaka J, Hanato J, Umegaki K, Yamada S. Antinociceptive effects of St. John's Wort, Harpagophytum Procumbens extract and grape seed proantocyanidins extract in mice. Biol Pharm Bull. 2008;31:240–245
  36. Velàzquez KT, Mohammad H, Sweitzer SM. Protein kinase C in pain: Involvement of multiple isoforms. Pharmacol Res. 2007;55:578–589

 This work was supported by grants from MIUR.

PII: S1526-5900(09)00610-5

doi: 10.1016/j.jpain.2009.06.013

The Journal of Pain
Volume 11, Issue 2 , Pages 149-159 , February 2010

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