The Journal of Pain
Volume 11, Issue 7 , Pages 621-627 , July 2010

Assessing Aδ Fiber Function With Lidocaine Using Intraepidermal Electrical Stimulation

  • Naofumi Otsuru

      Affiliations

    • Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    • Department of Physiological Sciences, School of Life Sciences, Graduate University for Advanced Studies, Hayama, Kanagawa, Japan
    • Corresponding Author InformationAddress reprint requests to Dr Naofumi Otsuru, Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.
    • ,
  • Koji Inui

      Affiliations

    • Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    • ,
  • Koya Yamashiro

      Affiliations

    • Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    • Department of Physiological Sciences, School of Life Sciences, Graduate University for Advanced Studies, Hayama, Kanagawa, Japan
    • ,
  • Takahiro Miyazaki

      Affiliations

    • Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    • Department of Physiological Sciences, School of Life Sciences, Graduate University for Advanced Studies, Hayama, Kanagawa, Japan
    • ,
  • Yasuyuki Takeshima

      Affiliations

    • Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    • ,
  • Ryusuke Kakigi

      Affiliations

    • Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    • Japan Society for the Promotion of Science, Tokyo, Japan

Received 1 May 2009 ,Revised 9 July 2009 ,Accepted 2 October 2009.

References 

  1. Agostino R, Cruccu G, Iannetti GD, Innocenti P, Romaniello A, Truini A, et al. Trigeminal small-fibre dysfunction in patients with diabetes mellitus: A study with laser evoked potentials and corneal reflex. Clin Neurophysiol. 2000;111:2264–2267
  2. Agostino R, Cruccu G, Romaniello A, Innocenti P, Inghilleri M, Manfredi M. Dysfunction of small myelinated afferents in diabetic polyneuropathy, as assessed by laser evoked potentials. Clin Neurophysiol. 2000;111:270–276
  3. Arendt-Nielsen L, Bjerring P. Laser-induced pain for evaluation of local analgesia: A comparison of topical application (EMLA) and local injection (lidocaine). Anesth Analg. 1988;67:115–123
  4. Cruccu G, Anand P, Attal N, Garcia-Larrea L, Haanpää M, Jørum E, et al. EFNS guidelines on neuropathic pain assessment. Eur J Neurol. 2004;11:153–162
  5. Inui K, Tran TD, Hoshiyama M, Kakigi R. Preferential stimulation of Adelta fibers by intra-epidermal needle electrode in humans. Pain. 2002;96:247–252
  6. Inui K, Tran TD, Qiu Y, Wang X, Hoshiyama M, Kakigi R. Pain-related magnetic fields evoked by intra-epidermal electrical stimulation in humans. Clin Neurophysiol. 2002;113:298–304
  7. Inui K, Tran TD, Qiu Y, Wang X, Hoshiyama M, Kakigi R. A comparative magnetoencephalographic study of cortical activations evoked by noxious and innocuous somatosensory stimulations. Neuroscience. 2003;120:235–248
  8. Inui K, Tsuji T, Kakigi R. Temporal analysis of cortical mechanisms for pain relief by tactile stimuli in humans. Cereb Cortex. 2006;16:355–365
  9. Kakigi R, Endo C, Neshige R, Kuroda Y, Shibasaki H. Estimation of conduction velocity of A delta fibers in humans. Muscle Nerve. 1991;14:1193–1196
  10. Kakigi R, Shibasaki H, Ikeda A. Pain-related somatosensory evoked potentials following CO2 laser stimulation in man. Electroencephalogr Clin Neurophysiol. 1989;74:139–146
  11. Kakigi R, Shibasaki H, Tanaka K, Ikeda T, Oda K, Endo C, et al. CO2 laser-induced pain-related somatosensory evoked potentials in peripheral neuropathies: Correlation between electrophysiological and histopathological findings. Muscle Nerve. 1991;14:441–450
  12. Kruger L, Sampogna SL, Rodin BE, Clague J, Brecha N, Yeh Y. Thin-fiber cutaneous innervation and its intraepidermal contribution studies by labeling methods and neurotoxin treatment in Rats. Somatosens Res. 1985;17:335–356
  13. Lauria G. Small fibre neuropathies. Curr Opin Neurol. 2005;18:591–597
  14. Munger BL, Halata Z. The sensory innervation of primate facial skin, I: Hairly skin. Brain Res Rev. 1983;80:45–80
  15. Novotny GEK, Gommert-Novotny E. Intraepidermal nerves in human digital skin. Cell Tissue Res. 1988;254:111–117
  16. Ohsawa I, Inui K. Use of tripolar electrodes for minimization of current spread in uncut peripheral nerve stimulation. Neurosci Res. 2009;64:63–66
  17. Osio M, Zampini L, Muscia F, Valsecchi L, Comi C, Cargnel A, et al. Cutaneous silent period in human immunodeficiency virus-related peripheral neuropathy. J Peripher Nerv Syst. 2004;9:224–231
  18. Otsuru N, Inui K, Yamashiro K, Miyazaki T, Ohsawa I, Takeshima Y, et al. Selective stimulation of C fibers by an intra-epidermal needle electrode in humans. Open Pain J. 2009;4:53–56
  19. Pittenger GL, Ray M, Burcus NI, McNulty P, Basta B, Vinik AI. Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients. Diabetes Care. 2004;27:1974–1979
  20. Polydefkis M, Hauer P, Sheth S, Sirdofsky M, Griffin JW, McArthur JC. The time course of epidermal nerve fibre regeneration: Studies in normal controls and in people with diabetes, with and without neuropathy. Brain. 2004;127:1606–1615
  21. Quattrini C, Tavakoli M, Jeziorska M, Kallinikos P, Tesfaye S, Finnigan J, et al. Surrogate markers of small fiber damage in human diabetic neuropathy. Diabetes. 2007;56:2148–2154
  22. Romaniello A, Valls-sole J, Ianetti GD, Truini A, Manfredi M, Cruccu G. Nociceptive quality of the laser-evoked blink reflex in humans. J Neurophysiol. 2002;87:1386–1394
  23. Said G. Diabetic neuropathy: A review. Nat Clin Pract Neurol. 2007;3:331–340
  24. Sakai T, Tomiyasu S, Yamada H, Ono T, Sumikawa K. Quantitative and selective evaluation of differential sensory nerve block after transdermal lidocaine. Anesth Analg. 2004;98:248–251
  25. Shun CT, Chang YC, Wu HP, Hsieh SC, Lin WM, Lin YH, et al. Skin denervation in type 2 diabetes: Correlations with diabetic duration and functional impairments. Brain. 2004;127:1593–1605
  26. Sorensen L, Molyneaux L, Yue DK. The relationship among pain, sensory loss, and small nerve fibers in diabetes. Diabetes Care. 2006;29:883–887
  27. Sumner CJ, Sheth S, Griffin JW, Cornblath DR, Polydefkis M. The spectrum of neuropathy in diabetes and impaired glucose tolerance. Neurology. 2003;60:108–111
  28. Tran TD, Inui K, Hoshiyama M, Lam K, Kakigi R. Conduction velocity of the spinothalamic tract following CO2 laser stimulation of C-fibers in humans. Pain. 2002;95:125–131
  29. Zinman LH, Bril V, Perkins BA. Cooling detection thresholds in the assessment of diabetic sensory polyneuropathy: Comparison of CASE IV and Medoc instruments. Diabetes Care. 2004;27:1674–1679

 Supported by grants from the Ministry of Education, Sports, Sciences, and Technology and from the Ministry of Health, Labour, and Welfare, Japan.

PII: S1526-5900(09)00774-3

doi: 10.1016/j.jpain.2009.10.001

The Journal of Pain
Volume 11, Issue 7 , Pages 621-627 , July 2010

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