The Journal of Pain
Volume 11, Issue 5 , Pages 500-501 , May 2010

LOCF Approach to Handling Missing Data Overestimates the Pain Score Improvement of Drop-Outs

  • Alec B. O'Connor, MD, MPH

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Alec B. O'Connor, Box HMD/MED, Strong Memorial Hospital, 601 Elmwood Avenue, Rochester, NY 14642.

References 

  1. O'Connor AB. The need for improved access to FDA reviews. JAMA. 2009;302:191–193
  2. Shaibani A, Fares S, Selam JL, Arslanian A, Simpson J, Sen D, et al. Lacosamide in painful diabetic neuropathy: An 18-week double-blind placebo-controlled trial. J Pain. 2009;10:818–828
  3. US FDA . Approval package for: Application number 21-446 medical review(s). http://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/021446_LyricaTOC.cfmAccessed September 7, 2009
  4. Wymer JP, Simpson J, Sen D, Bongardt S. Efficacy and safety of lacosamide in diabetic neuropathic pain: An 18-week double-blind placebo-controlled trial of fixed-dose regimens. Clin J Pain. 2009;25:376–385

PII: S1526-5900(10)00016-7

doi: 10.1016/j.jpain.2010.01.001

The Journal of Pain
Volume 11, Issue 5 , Pages 500-501 , May 2010

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