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Effect of Topical Analgesia on Desensitization Following 8% Topical Capsaicin Application

Reduction of Pain and Spinal Nociceptive Transmission by Working Memory is Load Dependant

Pre-Exposure, But Not Overshadowing, Inhibits Nocebo Hyperalgesia
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    Issue Highlights

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    Pain Catastrophizing, Opioid Misuse, Opioid Use, and Opioid Dose in People With Chronic Musculoskeletal Pain: A Systematic Review

    Javier Martinez-Calderon, Mar Flores-Cortes, Jose Miguel Morales-Asencio, Alejandro Luque-Suarez
    DOI: https://doi.org/10.1016/j.jpain.2021.02.002
    Vol. 22, Issue 8, p879–891
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  • AAAPT Diagnostic Criteria for Acute Thoracic Surgery Pain

    Emine Ozgur Bayman, Michele Curatolo, Siamak Rahman, Timothy J. Brennan
    DOI: https://doi.org/10.1016/j.jpain.2021.03.148
    Vol. 22, Issue 8, p892–904
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    Does Cognitive Functioning Predict Chronic Pain in Older Adult? Results From the CoLaus|PsyCoLaus Longitudinal Study

    Isabelle Rouch, Jean-Michel Dorey, Marie-Pierre F. Strippoli, Mehdi Gholam, Pedro Marques-Vidal, Bernard Laurent, Armin von Gunten, Martin Preisig
    DOI: https://doi.org/10.1016/j.jpain.2021.01.007
    Vol. 22, Issue 8, p905–913
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    • Complete list of APS guidelines

    2020 Cited articles

    Featured Journal Club Article

    Sessions of prolonged continuous theta burst stimulation or high-frequency 10 Hz stimulation to the left dorsolateral prefrontal cortex for three days decreased pain sensitivity by modulation of the efficacy of conditioned pain modulation

    The 10 Hz repetitive transcranial magnetic stimulation (10 Hz-rTMS) to the left dorsolateral prefrontal cortex produces analgesia, probably by activating the pain modulation system. A newer rTMS paradigm, called theta burst stimulation (TBS), has been developed. Unlike 10 Hz-rTMS, prolonged continuous TBS (pcTBS) mimics endogenous theta rhythms, which can improve induction of synaptic long-term potentiation. Therefore, this study investigated whether pcTBS to the left dorsolateral prefrontal cortex reduced pain sensitivity more efficiently compared with 10 Hz-rTMS, the analgesic effects lasted beyond the stimulation period, and the reduced pain sensitivity was associated with increased efficacy of conditioned pain modulation (CPM) and/or intracortical excitability. Sixteen subjects participated in a randomized cross-over study with pcTBS and 10 Hz-rTMS. Pain thresholds to heat (HPT), cold, pressure (PPT), intracortical excitability assessment, and CPM with mechanical and heat supra-pain threshold test stimuli and the cold pressor test as conditioning were collected before (Baseline), 3 (Day3) and 4 days (Day4) after 3-day session of rTMS. HPTs and PPTs increased with 10 Hz-rTMS and pcTBS at Day3 and Day4 compared with Baseline (P = .007). Based on pooled data from pcTBS and 10 Hz-rTMS, the increased PPTs correlated with increased efficacy of CPM at Day3 (P = .008), while no correlations were found at Day4 or with the intracortical excitability.

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    Cover image volume 22, Issue 8 Enlarge Cover

    August 2021
    Volume 22, Issue 8

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    Cover of May 2021 Issue

    The protease activated receptor (PAR) family is a group of G-protein coupled receptors activated by proteolytic cleavage of the extracellular domain. PARs are expressed in a variety of cell types with crucial roles in hemostasis, immune responses, inflammation, and pain. PAR3 is the least researched of the four PARs. This work aimed to better understand its potential function in the peripheral sensory nervous system by evaluating the role of PAR3, a G-protein coupled receptor, in nociception by developing a selective peptide agonist. These results suggest that PAR3 contributes to nociception in various contexts and plays a role in modulating the activity of other PARs. See Mwirigi, et al, Page 692.