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Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

      Abstract

      Sex-related influences on pain and analgesia have become a topic of tremendous scientific and clinical interest, especially in the last 10 to 15 years. Members of our research group published reviews of this literature more than a decade ago, and the intervening time period has witnessed robust growth in research regarding sex, gender, and pain. Therefore, it seems timely to revisit this literature. Abundant evidence from recent epidemiologic studies clearly demonstrates that women are at substantially greater risk for many clinical pain conditions, and there is some suggestion that postoperative and procedural pain may be more severe among women than men. Consistent with our previous reviews, current human findings regarding sex differences in experimental pain indicate greater pain sensitivity among females compared with males for most pain modalities, including more recently implemented clinically relevant pain models such as temporal summation of pain and intramuscular injection of algesic substances. The evidence regarding sex differences in laboratory measures of endogenous pain modulation is mixed, as are findings from studies using functional brain imaging to ascertain sex differences in pain-related cerebral activation. Also inconsistent are findings regarding sex differences in responses to pharmacologic and non-pharmacologic pain treatments. The article concludes with a discussion of potential biopsychosocial mechanisms that may underlie sex differences in pain, and considerations for future research are discussed.

      Perspective

      This article reviews the recent literature regarding sex, gender, and pain. The growing body of evidence that has accumulated in the past 10 to 15 years continues to indicate substantial sex differences in clinical and experimental pain responses, and some evidence suggests that pain treatment responses may differ for women versus men.

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      References

        • al'Absi M.
        • France C.
        • Harju A.
        • France J.
        • Wittmers L.
        Adrenocortical and nociceptive responses to opioid blockade in hypertension-prone men and women.
        Psychosom Med. 2006; 68 (2006): 292-298
        • al'Absi M.
        • France C.R.
        • Ring C.
        • France J.
        • Harju A.
        • McIntyre D.
        • Wittmers L.E.
        Nociception and baroreceptor stimulation in hypertension-prone men and women.
        Psychophysiology. 2005; 42: 83-91
        • al'Absi M.
        • Petersen K.L.
        Blood pressure but not cortisol mediates stress effects on subsequent pain perception in healthy men and women.
        Pain. 2003; 106: 285-295
        • al'Absi M.
        • Petersen K.L.
        • Wittmers L.E.
        Adrenocortical and hemodynamic predictors of pain perception in men and women.
        Pain 96:. 2002; : 197-204
        • al'Absi M.
        • Wittmers L.E.
        • Ellestad D.
        • Nordehn G.
        • Kim S.W.
        • Kirschbaum C.
        • Grant J.E.
        Sex differences in pain and hypothalamic-pituitary-adrenocortical responses to opioid blockade.
        Psychosom Med. 2004; 66: 198-206
        • Aloisi A.M.
        • Bachiocco V.
        • Costantino A.
        • Stefani R.
        • Ceccarelli I.
        • Bertaccini A.
        • Meriggiola M.C.
        Cross-sex hormone administration changes pain in transsexual women and men.
        Pain. 2007; 132: S60-S67
        • Aloisi A.M.
        • Bonifazi M.
        Sex hormones, central nervous system and pain.
        Horm Behav. 2006; 50: 1-7
        • Aloisi A.M.
        • Ceccarelli I.
        Role of gonadal hormones in formalin-induced pain responses of male rats: Modulation by estradiol and naloxone administration.
        Neuroscience. 2000; 95: 559-566
        • Alonso C.
        • Loevinger B.L.
        • Muller D.
        • Coe C.L.
        Menstrual cycle influences on pain and emotion in women with fibromyalgia.
        J Psychosom Res. 2004; 57: 451-458
        • Anderberg U.M.
        • Marteinsdottir I.
        • Hallman J.
        • Backstrom T.
        Variability in cyclicity affects pain and other symptoms in female fibromyalgia syndrome patients.
        J Musculoskel Pain. 1998; 6: 5-22
        • Andersen R.E.
        • Crespo C.J.
        • Ling S.M.
        • Bathon J.M.
        • Bartlett S.J.
        Prevalence of significant knee pain among older Americans: results from the Third National Health and Nutrition Examination Survey.
        J Am Geriatr Soc. 1999; 47: 1435-1438
        • Applegate K.L.
        • Keefe F.J.
        • Siegler I.C.
        • Bradley L.A.
        • McKee D.C.
        • Cooper K.S.
        • Riordan P.
        Does personality at college entry predict number of reported pain conditions at mid-life? A longitudinal study.
        J Pain. 2005; 6: 92-97
        • Arjona A.
        • Rubi-Callejon J.
        • Guardado-Santervas P.
        • Serrano-Castro P.
        • Olivares J.
        Menstrual tension-type headache: Evidence for its existence.
        Headache. 2007; 47: 100-103
        • Ashina S.
        • Bendtsen L.
        • Ashina M.
        • Magerl W.
        • Jensen R.
        Generalized hyperalgesia in patients with chronic tension-type headache.
        Cephalalgia. 2006; 26: 940-948
        • Aslaksen P.M.
        • Myrbakk I.N.
        • Hoifodt R.S.
        • Flaten M.A.
        The effect of experimenter gender on autonomic and subjective responses to pain stimuli.
        Pain. 2007; 129: 260-268
        • Aubrun F.
        • Salvi N.
        • Coriat P.
        • Riou B.
        Sex- and age-related differences in morphine requirements for postoperative pain relief.
        Anesthesiology. 2005; 103: 156-160
        • Averbuch M.
        • Katzper M.
        A search for sex differences in response to analgesia.
        Arch Intern Med. 2000; 160: 3424-3428
        • Averbuch M.
        • Katzper M.
        Gender and the placebo analgesic effect in acute pain.
        Clin Pharmacol Ther. 2001; 70: 287-291
        • Ayesh E.E.
        • Jensen T.S.
        • Svensson P.
        Somatosensory function following painful repetitive electrical stimulation of the human temporomandibular joint and skin.
        Exp Brain Res. 2007; 179: 415-425
        • Baad-Hansen L.
        • Poulsen H.F.
        • Jensen H.M.
        • Svensson P.
        Lack of sex differences in modulation of experimental intraoral pain by diffuse noxious inhibitory controls (DNIC).
        Pain. 2005; 116: 359-365
        • Bajaj P.
        • Bajaj P.
        • Madsen H.
        • Arendt-Nielsen L.
        A comparison of modality-specific somatosensory changes during menstruation in dysmenorrheic and nondysmenorrheic women.
        Clin J Pain. 2002; 18: 180-190
        • Bar K.J.
        • Brehm S.
        • Boettger M.K.
        • Boettger S.
        • Wagner G.
        • Sauer H.
        Pain perception in major depression depends on pain modality.
        Pain. 2005; 117: 97-103
        • Barrero L.H.
        • Hsu Y.H.
        • Terwedow H.
        • Perry M.J.
        • Dennerlein J.T.
        • Brain J.D.
        • Xu X.
        Prevalence and physical determinants of low back pain in a rural Chinese population.
        Spine. 2006; 31: 2728-2734
        • Bassols A.
        • Bosch F.
        • Campillo M.
        • Canellas M.
        • Banos J.E.
        An epidemiological comparison of pain complaints in the general population of Catalonia (Spain).
        Pain. 1999; 83: 9-16
        • Bastos J.L.
        • Gigante D.P.
        • Peres K.G.
        Toothache prevalence and associated factors: A population based study in southern Brazil.
        Oral Dis. 2008; 14: 320-326
        • Bekker M.H.
        • van Mens-Verhulst J.
        Anxiety disorders: Sex differences in prevalence, degree, and background, but gender-neutral treatment.
        Gend Med. 2007; 4: S178-S193
        • Bellamy N.
        • Buchanan W.W.
        • Goldsmith C.H.
        • Campbell J.
        • Stitt L.W.
        Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.
        J Rheumatol. 1988; 15: 1833-1840
        • Bennett M.
        The LANSS Pain Scale: The Leeds assessment of neuropathic symptoms and signs.
        Pain. 2001; 92: 147-157
        • Bereiter D.A.
        • Cioffi J.L.
        • Bereiter D.F.
        Oestrogen receptor-immunoreactive neurons in the trigeminal sensory system of male and cycling female rats.
        Arch Oral Biol. 2005; 50: 971-979
        • Bergman S.
        • Herrstrom P.
        • Hogstrom K.
        • Petersson I.F.
        • Svensson B.
        • Jacobsson L.T.
        Chronic musculoskeletal pain, prevalence rates, and sociodemographic associations in a Swedish population study.
        J Rheumatol. 2001; 28: 1369-1377
        • Bergman S.
        • Herrstrom P.
        • Jacobsson L.T.
        • Petersson I.F.
        Chronic widespread pain: A three year followup of pain distribution and risk factors.
        J Rheumatol. 2002; 29: 818-825
        • Berkley K.J.
        Vive la difference.
        TINS. 1992; 15: 331-332
        • Berkley K.J.
        Sex differences in pain.
        Behav Brain Sci. 1997; 20: 371-380
        • Berman S.M.
        • Naliboff B.D.
        • Suyenobu B.
        • Labus J.S.
        • Stains J.
        • Bueller J.A.
        • Ruby K.
        • Mayer E.A.
        Sex differences in regional brain response to aversive pelvic visceral stimuli.
        Am J Physiol Regul Integr Comp Physiol. 2006; 291: R268-R276
        • Bernardes S.F.
        • Keogh E.
        • Lima M.L.
        Bridging the gap between pain and gender research: A selective literature review.
        Eur J Pain. 2008; 12: 427-440
        • Bhatt S.D.
        • Dluzen D.E.
        Dopamine transporter function differences between male and female CD-1 mice.
        Brain Res. 2005; 28: 188-195
        • Bhattacharjee M.
        • Bhatia R.
        • Mathur R.
        Gender specificity of sucrose induced analgesia in human adults.
        Ind J Physiol Pharmacol. 2007; 51: 410-414
        • Bijur P.E.
        • Esses D.
        • Birnbaum A.
        • Chang A.K.
        • Schechter C.
        • Gallagher E.J.
        Response to morphine in male and female patients: analgesia and adverse events.
        Clin J Pain. 2008; 24: 192-198
        • Bingefors K.
        • Isacson D.
        Epidemiology, co-morbidity, and impact on health-related quality of life of self-reported headache and musculoskeletal pain: A gender perspective.
        Eur J Pain. 2004; 8: 435-450
        • Bliddal H.
        • Nneskiold-Samsoe B.
        Chronic widespread pain in the spectrum of rheumatological diseases.
        Best Pract Res Clin Rheumatol. 2007; 21: 391-402
        • Blyth F.M.
        • March L.M.
        • Brnabic A.J.
        • Jorm L.R.
        • Williamson M.
        • Cousins M.J.
        Chronic pain in Australia: A prevalence study.
        Pain. 2001; 89: 127-134
        • Bodnar R.J.
        • Commons K.
        • Pfaff D.W.
        Central Neural States Relating Sex and Pain.
        Johns Hopkins University Press, Baltimore2002
        • Bouhassira D.
        • Attal N.
        • Alchaar H.
        • Boureau F.
        • Brochet B.
        • Bruxelle J.
        • Cunin G.
        • Fermanian J.
        • Ginies P.
        • Grun-Overdyking A.
        • Jafari-Schluep H.
        • Lanteri-Minet M.
        • Laurent B.
        • Mick G.
        • Serrie A.
        • Valade D.
        • Vicaut E.
        Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4).
        Pain. 2005; 114: 29-36
        • Bouhassira D.
        • Lanteri-Minet M.
        • Attal N.
        • Laurent B.
        • Touboul C.
        Prevalence of chronic pain with neuropathic characteristics in the general population.
        Pain. 2008; 136: 380-387
        • Bragdon E.E.
        • Light K.C.
        • Costello N.L.
        • Sigurdsson A.
        • Bunting S.
        • Bhalang K.
        • Maixner W.
        Group differences in pain modulation: Pain-free women compared to pain-free men and to women with TMD.
        Pain. 2002; 96: 227-237
        • Brandes J.L.
        The influence of estrogen on migraine: a systematic review.
        JAMA. 2006; 295: 1824-1830
        • Breivik H.
        • Collett B.
        • Ventafridda V.
        • Cohen R.
        • Gallacher D.
        Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment.
        Eur J Pain. 2006; 10: 287-333
        • Briscoe M.E.
        Why do people go to the doctor? Sex differences in the correlates of GP consultation.
        Soc Sci Med. 1987; 25: 507-513
        • Brun Sundblad G.M.
        • Saartok T.
        • Engstrom L.M.
        Prevalence and co-occurrence of self-rated pain and perceived health in school-children: Age and gender differences.
        Eur J Pain. 2007; 11: 171-180
        • Brynhildsen J.O.
        • Bjors E.
        • Skarsgard C.
        • Hammar M.L.
        Is hormone replacement therapy a risk factor for low back pain among postmenopausal women?.
        Spine. 1998; 23: 809-813
        • Burns J.W.
        • Johnson B.J.
        • Devine J.
        • Mahoney N.
        • Pawl R.
        Anger management style and the prediction of treatment outcome among male and female chronic pain patients.
        Behav Res Ther. 1998; 36: 1051-1062
        • Bush F.M.
        • Harkins S.W.
        • Harrington W.G.
        • Price D.D.
        Analysis of gender effects on pain perception and symptom presentation in temporomandibular joint pain.
        Pain. 1993; 53: 73-80
        • Buskila D.
        • Abramov G.
        • Biton A.
        • Neumann L.
        The prevalence of pain complaints in a general population in Israel and its implications for utilization of health services.
        J Rheumatol. 2000; 27: 1521-1525
        • Cairns B.E.
        • Hu J.W.
        • Arendt-Nielsen L.
        • Sessle B.J.
        • Svensson P.
        Sex-related differences in human pain and rat afferent discharge evoked by injection of glutamate into the masseter muscle.
        J Neurophysiol. 2001; 86: 782-791
        • Cairns B.E.
        • Wang K.
        • Hu J.W.
        • Sessle B.J.
        • Arendt-Nielsen L.
        • Svensson P.
        The effect of glutamate-evoked masseter muscle pain on the human jaw-stretch reflex differs in men and women.
        J Orofac Pain. 2003; 17: 317-325
        • Calabrese E.J.
        Estrogen and related compounds: biphasic dose responses.
        Crit Rev Toxicol. 2001; 31: 503-515
        • Calderone K.L.
        The influence of gender on the frequency of pain and sedative medication administered to postoperative patients.
        Sex Roles. 1990; 23: 713-725
        • Carlsson M.
        • Svensson K.
        • Eriksson E.
        • Carlsson A.
        Rat brain serotonin: biochemical and functional evidence for a sex difference.
        J Neural Transm. 1985; 63: 297-313
        • Carmona L.
        • Ballina J.
        • Gabriel R.
        • Laffon A.
        The burden of musculoskeletal diseases in the general population of Spain: Results from a national survey.
        Ann Rheum Dis. 2001; 60: 1040-1045
        • Catala E.
        • Reig E.
        • Artes M.
        • Aliaga L.
        • Lopez J.S.
        • Segu J.L.
        Prevalence of pain in the Spanish population: Telephone survey in 5000 homes.
        Eur J Pain. 2002; 6: 133-140
        • Ceccarelli I.
        • Fiorenzani P.
        • Grasso G.
        • Lariviere W.R.
        • Massafra C.
        • Massai L.
        • Muscettola M.
        • Aloisi A.M.
        Estrogen and mu-opioid receptor antagonists counteract the 17 beta-estradiol-induced licking increase and interferon-gamma reduction occurring during the formalin test in male rats.
        Pain. 2004; 111: 181-190
        • Cepeda M.S.
        • Carr D.B.
        Women experience more pain and require more morphine than men to achieve a similar degree of analgesia.
        Anesth Analg. 2003; 97: 1464-1468
        • Cepeda M.S.
        • Farrar J.T.
        • Baumgarten M.
        • Boston R.
        • Carr D.B.
        • Strom B.L.
        Side effects of opioids during short-term administration: Effect of age, gender, and race.
        Clin Pharmacol Ther. 2003; 74: 102-112
        • Chang K.Y.
        • Tsou M.Y.
        • Chan K.H.
        • Sung C.S.
        • Chang W.K.
        Factors affecting patient-controlled analgesia requirements.
        J Formos Med Assoc. 2006; 105: 918-925
        • Chen E.H.
        • Shofer F.S.
        • Dean A.J.
        • Hollander J.E.
        • Baxt W.G.
        • Robey J.L.
        • Sease K.L.
        • Mills A.M.
        Gender disparity in analgesic treatment of emergency department patients with acute abdominal pain.
        Acad Emerg Med. 2008; 15: 414-418
        • Chesterton L.S.
        • Barlas P.
        • Foster N.E.
        • Baxter G.D.
        • Wright C.C.
        Gender differences in pressure pain threshold in healthy humans.
        Pain. 2003; 101: 259-266
        • Chia Y.Y.
        • Chow L.H.
        • Hung C.C.
        • Liu K.
        • Ger L.P.
        • Wang P.N.
        Gender and pain upon movement are associated with the requirements for postoperative patient-controlled iv analgesia: A prospective survey of 2,298 Chinese patients.
        Can J Anaesth. 2002; 49: 249-255
        • Choi J.C.
        • Park S.K.
        • Kim Y.H.
        • Shin Y.W.
        • Kwon J.S.
        • Kim J.S.
        • Kim J.W.
        • Kim S.Y.
        • Lee S.G.
        • Lee M.S.
        Different brain activation patterns to pain and pain-related unpleasantness during the menstrual cycle.
        Anesthesiology. 2006; 105: 120-127
        • Chopra A.
        • Saluja M.
        • Patil J.
        • Tandale H.S.
        Pain and disability, perceptions and beliefs of a rural Indian population: A WHO-ILAR COPCORD study: WHO-International League of Associations for Rheumatology: Community Oriented Program for Control of Rheumatic Diseases.
        J Rheumatol. 2002; 29: 614-621
        • Christmas C.
        • Crespo C.J.
        • Franckowiak S.C.
        • Bathon J.M.
        • Bartlett S.J.
        • Andersen R.E.
        How common is hip pain among older adults? Results from the Third National Health and Nutrition Examination Survey.
        J Fam Pract. 2002; 51: 345-348
        • Cimino R.
        • Farella M.
        • Michelotti A.
        • Pugliese R.
        • Martina R.
        Does the ovarian cycle influence the pressure-pain threshold of the masticatory muscles in symptom-free women?.
        J Orofac Pain. 2000; 14: 105-111
        • Compton P.
        • Charuvastra V.
        • Ling W.
        Effect of oral ketorolac and gender on human cold pressor pain tolerance.
        Clin Exp Pharmacol Physiol. 2003; 30: 759-763
        • Craft R.M.
        Sex differences in drug- and non-drug-induced analgesia.
        Life Sci. 2003; 72: 2675-2688
        • Craft R.M.
        Sex differences in opioid analgesia: From mouse to man.
        Clin J Pain. 2003; 19: 175-186
        • Craft R.M.
        Modulation of pain by estrogens.
        Pain. 2007; 132: S3-S12
        • Craft R.M.
        • Lee D.A.
        NMDA antagonist modulation of morphine antinociception in female vs male rats.
        Pharmacol Biochem Behav. 2005; 80: 639-649
        • Craft R.M.
        • Mogil J.S.
        • Aloisi A.M.
        Sex differences in pain and analgesia: The role of gonadal hormones.
        Eur J Pain. 2004; 8: 397-411
        • Criste A.
        Do nurse anesthetists demonstrate gender bias in treating pain? A national survey using a standardized pain model.
        AANA J. 2003; 71: 206-209
        • Dahlof C.
        • Linde M.
        One-year prevalence of migraine in Sweden: A population-based study in adults.
        Cephalalgia. 2001; 21: 664-671
        • Daly C.
        • Clemens F.
        • Lopez Sendon J.L.
        • Tavazzi L.
        • Boersma E.
        • Danchin N.
        • Delahaye F.
        • Gitt A.
        • Julian D.
        • Mulcahy D.
        • Ruzyllo W.
        • Thygesen K.
        • Verheugt F.
        • Fox K.M.
        Gender differences in the management and clinical outcome of stable angina.
        Circulation. 2006; 113: 490-498
        • Dao T.T.
        • LeResche L.
        Gender differences in pain.
        J Orofac Pain. 2000; 14: 169-184
        • De Cosmo G.
        • Congedo E.
        • Lai C.
        • Primieri P.
        • Dottarelli A.
        • Aceto P.
        Preoperative psychologic and demographic predictors of pain perception and tramadol consumption using intravenous patient-controlled analgesia.
        Clin J Pain. 2008; 24: 399-405
        • De Leeuw R.
        • Albuquerque R.J.
        • Andersen A.H.
        • Carlson C.R.
        Influence of estrogen on brain activation during stimulation with painful heat.
        J Oral Maxillofac Surg. 2006; 64: 158-166
        • de Leeuw R.
        • Albuquerque R.J.
        • Andersen A.H.
        • Carlson C.R.
        Influence of estrogen on brain activation during stimulation with painful heat.
        J Oral Maxillofac Surg. 2006; 64: 158-166
        • de Mos M.
        • de Bruijn A.G.
        • Huygen F.J.
        • Dieleman J.P.
        • Stricker B.H.
        • Sturkenboom M.C.
        The incidence of complex regional pain syndrome: a population-based study.
        Pain. 2007; 129: 12-20
        • De C.G.
        • Congedo E.
        • Lai C.
        • Primieri P.
        • Dottarelli A.
        • Aceto P.
        Preoperative psychologic and demographic predictors of pain perception and tramadol consumption using intravenous patient-controlled analgesia.
        Clin J Pain. 2008; 24: 399-405
        • Deaux K.
        • Major B.
        Putting gender into context: An interactive model of gender-related behavior.
        Psychol Rev. 1987; 94: 369-389
        • Defrin R.
        • Benstein-Sheraizin A.
        • Bezalel A.
        • Mantzur O.
        • Arendt-Nielsen L.
        The spatial characteristics of the painful thermal grill illusion.
        Pain. 2008; 138: 577-586
        • Defrin R.
        • Pope G.
        • Davis K.D.
        Interactions between spatial summation, 2-point discrimination and habituation of heat pain.
        Eur J Pain. 2008; 12: 900-909
        • Deleu D.
        • Khan M.A.
        • Al Shehab T.A.
        Prevalence and clinical characteristics of headache in a rural community in Oman.
        Headache. 2002; 42: 963-973
        • Derbyshire S.W.
        • Nichols T.
        • Firestone L.
        • Townsend D.
        • Jones A.
        Gender differences in patterns of cerebral activation during equal experience of painful laser stimulation.
        J Pain. 2002; 3: 401-411
        • Dersh J.
        • Polatin P.B.
        • Gatchel R.J.
        Chronic pain and psychopathology: Research findings and theoretical considerations.
        Psychosom Med. 2002; 64: 773-786
        • Dickersin K.
        The existence of publication bias and risk factors for its occurrence.
        JAMA. 1990; 263: 1385-1389
        • Dickinson S.L.
        • Curzon G.
        5-Hydroxytryptamine-mediated behaviour in male and female rats.
        Neuropharmacology. 1986; 25: 771-776
        • Dixon K.E.
        • Thorn B.E.
        • Ward L.C.
        An evaluation of sex differences in psychological and physiological responses to experimentally-induced pain: A path analytic description.
        Pain. 2004; 112: 188-196
        • Dong X.D.
        • Mann M.K.
        • Kumar U.
        • Svensson P.
        • Arendt-Nielsen L.
        • Hu J.W.
        • Sessle B.J.
        • Cairns B.E.
        Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity.
        Neuroscience. 2007; 146: 822-832
        • Drahovzal D.N.
        • Stewart S.H.
        • Sullivan M.J.
        Tendency to catastrophize somatic sensations: Pain catastrophizing and anxiety sensitivity in predicting headache.
        Cogn Behav Ther. 2006; 35: 226-235
        • Drobek W.
        • Schoenaers J.
        • De Laat A.
        Hormone-dependent fluctuations of pressure pain threshold and tactile threshold of the temporalis and masseter muscle.
        J Oral Rehabil. 2002; 29: 1042-1051
        • Drossman D.A.
        • Li Z.
        • Andruzzi E.
        • Temple R.D.
        • Talley N.J.
        • Thompson W.G.
        • Whitehead W.E.
        • Janssens J.
        • Funch Jensen P.
        • Corazziari E.
        • Richter J.
        • Koch G.
        US householder survey of functional gastrointestinal disorders: Prevalence, sociodemography, and health impact.
        Dig Dis Sci. 1993; 38: 1569-1580
        • Edrington J.M.
        • Paul S.
        • Dodd M.
        • West C.
        • Facione N.
        • Tripathy D.
        • Koo P.
        • Schumacher K.
        • Miaskowski C.
        No evidence for sex differences in the severity and treatment of cancer pain.
        J Pain Symptom Manage. 2004; 28: 225-232
        • Edwards R.R.
        Individual differences in endogenous pain modulation as a risk factor for chronic pain.
        Neurology. 2005; 9: 437-443
        • Edwards R.R.
        • Augustson E.
        • Fillingim R.B.
        Sex-specific effects of pain-related anxiety on adjustment to chronic pain.
        Clin J Pain. 2000; 16: 46-53
        • Edwards R.R.
        • Augustson E.
        • Fillingim R.B.
        Differential relationships between anxiety and treatment-associated pain reduction among male and female chronic pain patients.
        Clin J Pain. 2003; 19: 208-216
        • Edwards R.R.
        • Doleys D.M.
        • Lowery D.
        • Fillingim R.B.
        Pain tolerance as a predictor of outcome following multidisciplinary treatment for chronic pain: Differential effects as a function of sex.
        Pain. 2003; 106: 419-426
        • Edwards R.R.
        • Fillingim R.B.
        Ethnic differences in thermal pain responses.
        Psychosom Med. 1999; 61: 346-354
        • Edwards R.R.
        • Fillingim R.B.
        • Ness T.J.
        Age-related differences in endogenous pain modulation: A comparison of diffuse noxious inhibitory controls in healthy older and younger adults.
        Pain. 2003; 101: 155-165
        • Edwards R.R.
        • Haythornthwaite J.A.
        • Sullivan M.J.
        • Fillingim R.B.
        Catastrophizing as a mediator of sex differences in pain: Differential effects for daily pain versus laboratory-induced pain.
        Pain. 2004; 111: 335-341
        • Edwards R.R.
        • Ness T.J.
        • Weigent D.A.
        • Fillingim R.B.
        Individual differences in diffuse noxious inhibitory controls (DNIC): Association with clinical variables.
        Pain. 2003; 106: 427-437
        • Eggen A.E.
        The Tromso Study: Frequency and predicting factors of analgesic drug use in a free-living population (12-56 years).
        J Clin Epidemiol. 1993; 46: 1297-1304
        • El-Metwally A.
        • Salminen J.J.
        • Auvinen A.
        • Macfarlane G.
        • Mikkelsson M.
        Risk factors for development of non-specific musculoskeletal pain in preteens and early adolescents: A prospective 1-year follow-up study.
        BMC Musculoskel Disord. 2007; 8: 46
        • Ellermeier W.
        • Westphal W.
        Gender differences in pain ratings and pupil reactions to painful pressure stimuli.
        Pain. 1995; 61: 435-439
        • Essick G.
        • Guest S.
        • Martinez E.
        • Chen C.
        • McGlone F.
        Site-dependent and subject-related variations in perioral thermal sensitivity.
        Somatosens Mot Res. 2004; 21: 159-175
        • Falla D.
        • Arendt-Nielsen L.
        • Farina D.
        Gender-specific adaptations of upper trapezius muscle activity to acute nociceptive stimulation.
        Pain. 2008; 15: 217-225
        • Fejer R.
        • Hartvigsen J.
        • Kyvik K.O.
        • Jordan A.
        • Christensen H.W.
        • Hoilund-Carlsen P.F.
        The Funen Neck and Chest Pain study: Analysing non-response bias by using national vital statistic data.
        Eur J Epidemiol. 2006; 21: 171-180
        • Fernandez-Liz E.
        • Modamio P.
        • Catalan A.
        • Lastra C.F.
        • Rodriguez T.
        • Marino E.L.
        Identifying how age and gender influence prescription drug use in a primary health care environment in Catalonia, Spain.
        Br J Clin Pharmacol. 2008; 65: 407-417
        • Ferry S.
        • Hannaford P.
        • Warskyj M.
        • Lewis M.
        • Croft P.
        Carpal tunnel syndrome: A nested case-control study of risk factors in women.
        Am J Epidemiol. 2000; 15: 566-574
        • Fillingim R.B.
        Sex, gender and pain: Women and men really are different.
        Curr Rev Pain. 2000; 4: 24-30
        • Fillingim R.B.
        Sex differences in pain: Translational challenges and opportunities.
        in: Mao J. Translational Pain Research. Nova Science Publishers, Inc, New York2006: 293-314
        • Fillingim R.B.
        • Browning A.D.
        • Powell T.
        • Wright R.A.
        Sex differences in perceptual and cardiovascular responses to pain: The influence of a perceived ability manipulation.
        J Pain. 2002; 3: 439-445
        • Fillingim R.B.
        • Edwards R.R.
        The association of hormone replacement therapy with experimental pain responses in postmenopausal women.
        Pain. 2001; 92: 229-234
        • Fillingim R.B.
        • Edwards R.R.
        • Powell T.
        The relationship of sex and clinical pain to experimental pain responses.
        Pain. 1999; 83: 419-425
        • Fillingim R.B.
        • Gear R.W.
        Sex differences in opioid analgesia: clinical and experimental findings.
        Eur J Pain. 2004; 8: 413-425
        • Fillingim R.B.
        • Hastie B.A.
        • Ness T.J.
        • Glover T.L.
        • Campbell C.M.
        • Staud R.
        Sex-related psychological predictors of baseline pain perception and analgesic responses to pentazocine.
        Biol Psychol. 2005; 69: 97-112
        • Fillingim R.B.
        • Kaplan L.
        • Staud R.
        • Ness T.J.
        • Glover T.L.
        • Campbell C.M.
        • Mogil J.S.
        • Wallace M.R.
        The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans.
        J Pain. 2005; 6: 159-167
        • Fillingim R.B.
        • Keefe F.J.
        • Light K.C.
        • Booker D.K.
        • Maixner W.
        The influence of gender and psychological factors on pain perception.
        J Gender Cult Health. 1996; 1: 21-36
        • Fillingim R.B.
        • Maddux V.
        • Shackelford J.M.
        Sex differences in heat pain thresholds as a function of assessment method and rate of rise.
        Somatosensory Mot Res. 1999; 16: 57-62
        • Fillingim R.B.
        • Maixner W.
        Gender differences in the responses to noxious stimuli.
        Pain Forum. 1995; 4: 209-221
        • Fillingim R.B.
        • Maixner W.
        The influence of resting blood pressure and gender on pain responses.
        Psychosom Med. 1996; 58: 326-332
        • Fillingim R.B.
        • Maixner W.
        • Girdler S.S.
        • Light K.C.
        • Harris M.B.
        • Sheps D.S.
        • Mason G.A.
        Ischemic but not thermal pain sensitivity varies across the menstrual cycle.
        Psychosom Med. 1997; 59: 512-520
        • Fillingim R.B.
        • Maixner W.
        • Kincaid S.
        • Silva S.
        Sex differences in temporal summation but not sensory-discriminative processing of thermal pain.
        Pain. 1998; 75: 121-127
        • Fillingim R.B.
        • Ness T.J.
        Sex-related hormonal influences on pain and analgesic responses.
        Neurosci Biobehav Rev. 2000; 24: 485-501
        • Fillingim R.B.
        • Ness T.J.
        • Glover T.L.
        • Campbell C.M.
        • Hastie B.A.
        • Price D.D.
        • Staud R.
        Morphine responses and experimental pain: Sex differences in side effects and cardiovascular responses but not analgesia.
        J Pain. 2005; 6: 116-124
        • Fillingim R.B.
        • Ness T.J.
        • Glover T.L.
        • Campbell C.M.
        • Price D.D.
        • Staud R.
        Experimental pain models reveal no sex differences in pentazocine analgesia in humans.
        Anesthesiology. 2004; 100: 1263-1270
        • Fillingim R.B.
        • Wilkinson C.S.
        • Powell T.
        Self-reported abuse history and pain complaints among healthy young adults.
        Clin J Pain. 1999; 15: 85-91
        • Flaten M.A.
        • Simonsen T.
        • Olsen H.
        Drug-related information generates placebo and nocebo responses that modify the drug response.
        Psychosom Med. 1999; 61: 250-255
        • France C.R.
        • Keefe F.J.
        • Emery C.F.
        • Affleck G.
        • France J.L.
        • Waters S.
        • Caldwell D.S.
        • Stainbrook D.
        • Hackshaw K.V.
        • Edwards C.
        Laboratory pain perception and clinical pain in post-menopausal women and age-matched men with osteoarthritis: Relationship to pain coping and hormonal status.
        Pain. 2004; 112: 274-281
        • France C.R.
        • Suchowiecki S.
        A comparison of diffuse noxious inhibitory controls in men and women.
        Pain. 1999; 81: 77-84
        • Frot M.
        • Feine J.S.
        • Bushnell M.C.
        Sex differences in pain perception and anxiety: A psychophysical study with topical capsaicin.
        Pain. 2004; 108: 230-236
        • Fumagalli F.
        • Jones S.
        • Bosse R.
        • Jaber M.
        • Giros B.
        • Missale C.
        • Wightman R.M.
        • Caron M.G.
        Inactivation of the dopamine transporter reveals essential roles of dopamine in the control of locomotion, psychostimulant response, and pituitary function.
        Adv Pharmacol. 1998; 42: 179-182
        • Gagliese L.
        • Gauthier L.R.
        • Macpherson A.K.
        • Jovellanos M.
        • Chan V.W.
        Correlates of postoperative pain and intravenous patient-controlled analgesia use in younger and older surgical patients.
        Pain Med. 2008; 9: 299-314
        • Garcia E.
        • Godoy-Izquierdo D.
        • Godoy J.F.
        • Perez M.
        • Lopez-Chicheri I.
        Gender differences in pressure pain threshold in a repeated measures assessment.
        Psychol Health Med. 2007; 12: 567-579
        • Gaumond I.
        • Arsenault P.
        • Marchand S.
        Specificity of female and male sex hormones on excitatory and inhibitory phases of formalin-induced nociceptive responses.
        Brain Res. 2005; 2: 105-111
        • Gazerani P.
        • Andersen O.K.
        • Arendt-Nielsen L.
        A human experimental capsaicin model for trigeminal sensitization: Gender-specific differences.
        Pain. 2005; 118: 155-163
        • Gazerani P.
        • Andersen O.K.
        • Arendt-Nielsen L.
        Site-specific, dose-dependent, and sex-related responses to the experimental pain model induced by intradermal injection of capsaicin to the foreheads and forearms of healthy humans.
        J Orofac Pain. 2007; 21: 289-302
        • Gazerani P.
        • Wang K.
        • Cairns B.E.
        • Svensson P.
        • Arendt-Nielsen L.
        Effects of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women.
        Pain. 2006; 124: 338-348
        • Ge H.Y.
        • Arendt-Nielsen L.
        • Farina D.
        • Madeleine P.
        Gender-specific differences in electromyographic changes and perceived pain induced by experimental muscle pain during sustained contractions of the upper trapezius muscle.
        Muscle Nerve. 2005; 32: 726-733
        • Ge H.Y.
        • Madeleine P.
        • Arendt-Nielsen L.
        Sex differences in temporal characteristics of descending inhibitory control: An evaluation using repeated bilateral experimental induction of muscle pain.
        Pain. 2004; 110: 72-78
        • Ge H.Y.
        • Madeleine P.
        • Arendt-Nielsen L.
        Gender differences in pain modulation evoked by repeated injections of glutamate into the human trapezius muscle.
        Pain. 2005; 113: 134-140
        • Ge H.Y.
        • Madeleine P.
        • Cairns B.E.
        • Arendt-Nielsen L.
        Hypoalgesia in the referred pain areas after bilateral injections of hypertonic saline into the trapezius muscles of men and women: A potential experimental model of gender-specific differences.
        Clin J Pain. 2006; 22: 37-44
        • Gear R.W.
        • Gordon N.C.
        • Heller P.H.
        • Paul S.
        • Miaskowski C.
        • Levine J.D.
        Gender difference in analgesic response to the kappa-opioid pentazocine.
        Neurosci Lett. 1996; 205: 207-209
        • Gear R.W.
        • Gordon N.C.
        • Hossaini-Zadeh M.
        • Lee J.S.
        • Miaskowski C.
        • Paul S.M.
        • Levine J.D.
        A subanalgesic dose of morphine eliminates nalbuphine anti-analgesia in postoperative pain.
        J Pain. 2008; 9: 337-341
        • Gear R.W.
        • Miaskowski C.
        • Gordon N.C.
        • Paul S.M.
        • Heller P.H.
        • Levine J.D.
        Kappa-opioids produce significantly greater analgesia in women than in men.
        Nat Med. 1996; 2: 1248-1250
        • Gear R.W.
        • Miaskowski C.
        • Gordon N.C.
        • Paul S.M.
        • Heller P.H.
        • Levine J.D.
        The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain.
        Pain. 1999; 83: 339-345
        • George S.Z.
        • Dannecker E.A.
        • Robinson M.E.
        Fear of pain, not pain catastrophizing, predicts acute pain intensity, but neither factor predicts tolerance or blood pressure reactivity: An experimental investigation in pain-free individuals.
        Eur J Pain. 2006; 10: 457-465
        • George S.Z.
        • Fritz J.M.
        • Childs J.D.
        • Brennan G.P.
        Sex differences in predictors of outcome in selected physical therapy interventions for acute low back pain.
        J Orthop Sports Phys Ther. 2006; 36: 354-363
        • George S.Z.
        • Wittmer V.T.
        • Fillingim R.B.
        • Robinson M.E.
        Sex and pain-related psychological variables are associated with thermal pain sensitivity for patients with chronic low back pain.
        J Pain. 2007; 8: 2-10
        • Gerdle B.
        • Bjork J.
        • Coster L.
        • Henriksson K.
        • Henriksson C.
        • Bengtsson A.
        Prevalence of widespread pain and associations with work status: A population study.
        BMC Musculoskel Disord. 2008; 9: 102
        • Gerdle B.
        • Bjork J.
        • Henriksson C.
        • Bengtsson A.
        Prevalence of current and chronic pain and their influences upon work and healthcare-seeking: A population study.
        J Rheumatol. 2004; 31: 1399-1406
        • Gesch D.
        • Bernhardt O.
        • Alte D.
        • Schwahn C.
        • Kocher T.
        • John U.
        • Hensel E.
        Prevalence of signs and symptoms of temporomandibular disorders in an urban and rural German population: Results of a population-based Study of Health in Pomerania.
        Quintessence Int. 2004; 35: 143-150
        • Gijsbers K.
        • Nicholson F.
        Experimental pain thresholds influenced by sex of experimenter.
        Percept Mot Skills. 2005; 101: 803-807
        • Girdler S.S.
        • Maixner W.
        • Naftel H.A.
        • Stewart P.W.
        • Moretz R.L.
        • Light K.C.
        Cigarette smoking, stress-induced analgesia and pain perception in men and women.
        Pain. 2005; 114: 372-385
        • Glasson J.C.
        • Sawyer W.T.
        • Lindley C.M.
        • Ginsberg B.
        Patient-specific factors affecting patient-controlled analgesia dosing.
        J Pain Palliat Care Pharmacother. 2002; 16: 5-21
        • Goldberg R.
        • Goff D.
        • Cooper L.
        • Luepker R.
        • Zapka J.
        • Bittner V.
        • Osganian S.
        • Lessard D.
        • Cornell C.
        • Meshack A.
        • Mann C.
        • Gilliland J.
        • Feldman H.
        Age and sex differences in presentation of symptoms among patients with acute coronary disease: The REACT Trial: Rapid Early Action for Coronary Treatment.
        Coron Artery Dis. 2000; 11: 399-407
        • Gordon N.C.
        • Gear R.W.
        • Heller P.H.
        • Paul S.
        • Miaskowski C.
        • Levine J.D.
        Enhancement of morphine analgesia by the GABAB agonist baclofen.
        Neuroscience. 1995; 69: 345-349
        • Granot M.
        • Weissman-Fogel I.
        • Crispel Y.
        • Pud D.
        • Granovsky Y.
        • Sprecher E.
        • Yarnitsky D.
        Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: Do conditioning stimulus painfulness, gender and personality variables matter?.
        Pain. 2008; 136: 142-149
        • Granot M.
        • Yarnitsky D.
        • Itskovitz-Eldor J.
        • Granovsky Y.
        • Peer E.
        • Zimmer E.Z.
        Pain perception in women with dysmenorrhea.
        Obstet Gynecol. 2001; 98: 407-411
        • Green P.G.
        • Levine J.D.
        Sexual dimorphism in the effect of nonhabituating stress on neurogenic plasma extravasation.
        Eur J Neurosci. 2005; 21: 486-492
        • Greenspan J.D.
        • Craft R.M.
        • LeResche L.
        • Arendt-Nielsen L.
        • Berkley K.J.
        • Fillingim R.B.
        • Gold M.S.
        • Holdcroft A.
        • Lautenbacher S.
        • Mayer E.A.
        • Mogil J.S.
        • Murphy A.Z.
        • Traub R.J.
        Studying sex and gender differences in pain and analgesia: A consensus report.
        Pain. 2007; 132: S26-S45
        • Grisel J.E.
        • Allen S.
        • Nemmani K.V.
        • Fee J.R.
        • Carliss R.
        The influence of dextromethorphan on morphine analgesia in Swiss Webster mice is sex-specific.
        Pharmacol Biochem Behav. 2005; 81: 131-138
        • Guo H.R.
        • Chang Y.C.
        • Yeh W.Y.
        • Chen C.W.
        • Guo Y.L.
        Prevalence of musculoskeletal disorder among workers in Taiwan: A nationwide study.
        J Occup Health. 2004; 46: 26-36
        • Gupta A.
        • Silman A.J.
        • Ray D.
        • Morriss R.
        • Dickens C.
        • Macfarlane G.J.
        • Chiu Y.H.
        • Nicholl B.
        • McBeth J.
        The role of psychosocial factors in predicting the onset of chronic widespread pain: Results from a prospective population-based study.
        Rheumatology (Oxford). 2007; 46: 666-671
        • Gureje O.
        • Akinpelu A.O.
        • Uwakwe R.
        • Udofia O.
        • Wakil A.
        Comorbidity and impact of chronic spinal pain in Nigeria.
        Spine. 2007; 32: E495-E500
        • Gwee K.A.
        • Wee S.
        • Wong M.L.
        • Png D.J.
        The prevalence, symptom characteristics, and impact of irritable bowel syndrome in an Asian urban community.
        Am J Gastroenterol. 2004; 99: 924-931
        • Hagen K.
        • Zwart J.A.
        • Vatten L.
        • Stovner L.J.
        • Bovim G.
        Prevalence of migraine and non-migrainous headache–head-HUNT, a large population-based study.
        Cephalalgia. 2000; 20: 900-906
        • Haleem D.J.
        • Kennett G.A.
        • Curzon G.
        Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT.
        J Neural Transm Gen Sect. 1990; 79: 93-101
        • Hall G.C.
        • Carroll D.
        • Parry D.
        • McQuay H.J.
        Epidemiology and treatment of neuropathic pain: The UK primary care perspective.
        Pain. 2006; 122: 156-162
        • Hamberg K.
        • Risberg G.
        • Johansson E.E.
        • Westman G.
        Gender bias in physicians' management of neck pain: A study of the answers in a Swedish national examination.
        J Womens Health Gend Based Med. 2002; 11: 653-666
        • Hansen F.R.
        • Bendix T.
        • Skov P.
        • Jensen C.V.
        • Kristensen J.H.
        • Krohn L.
        • Schioeler H.
        Intensive, dynamic back-muscle exercises, conventional physiotherapy, or placebo-control treatment of low-back pain: A randomized, observer-blind trial.
        Spine. 1993; 18: 98-108
        • Hardt J.
        • Jacobsen C.
        • Goldberg J.
        • Nickel R.
        • Buchwald D.
        Prevalence of chronic pain in a representative sample in the United States.
        Pain Med. 2008; 9: 803-812
        • Heitkemper M.M.
        • Cain K.C.
        • Jarrett M.E.
        • Burr R.L.
        • Hertig V.
        • Bond E.F.
        Symptoms across the menstrual cycle in women with irritable bowel syndrome.
        Am J Gastroenterol. 2003; 98: 420-430
        • Heitkemper M.M.
        • Jarrett M.
        Pattern of gastrointestinal and somatic symptoms across the menstrual cycle.
        Gastroenterology. 1992; 102: 505-513
        • Helgeson V.S.
        The effects of masculinity and social support on recovery from myocardial infarction.
        Psychosom Med. 1991; 53: 621-633
        • Hellstrom B.
        • Lundberg U.
        Pain perception to the cold pressor test during the menstrual cycle in relation to estrogen levels and a comparison with men.
        Integr Physiol Behav Sci. 2000; 35: 132-141
        • Henderson L.A.
        • Gandevia S.C.
        • Macefield V.G.
        Gender differences in brain activity evoked by muscle and cutaneous pain: A retrospective study of single-trial fMRI data.
        Neuroimage. 2008; 39: 1867-1876
        • Henry P.
        • Auray J.P.
        • Gaudin A.F.
        • Dartigues J.F.
        • Duru G.
        • Lanteri-Minet M.
        • Lucas C.
        • Pradalier A.
        • Chazot G.
        • El H.A.
        Prevalence and clinical characteristics of migraine in France.
        Neurology. 2002; 59: 232-237
        • Herrero J.F.
        • Laird J.M.
        • Lopez-Garcia J.A.
        Wind-up of spinal cord neurones and pain sensation: Much ado about something?.
        Prog Neurobiol. 2000; 61: 169-203
        • Hirasawa M.
        • Hasegawa J.
        • Nishiyama J.
        • Suzuki T.
        Utilization of PCIA (patient-controlled intravenous analgesia) for postoperative analgesia of spine fusion.
        Tokai J Exp Clin Med. 2003; 28: 17-20
        • Ho K.H.
        • Ong B.K.
        A community-based study of headache diagnosis and prevalence in Singapore.
        Cephalalgia. 2003; 23: 6-13
        • Hobson A.R.
        • Furlong P.L.
        • Worthen S.F.
        • Hillebrand A.
        • Barnes G.R.
        • Singh K.D.
        • Aziz Q.
        Real-time imaging of human cortical activity evoked by painful esophageal stimulation.
        Gastroenterology. 2005; 128: 610-619
        • Hoffmann D.E.
        • Tarzian A.J.
        The girl who cried pain: A bias against women in the treatment of pain.
        J Law Med Ethics. 2001; 29: 13-27
        • Huguet A.
        • Miro J.
        The severity of chronic pediatric pain: An epidemiological study.
        J Pain. 2008; 9: 226-236
        • Ihlebaek C.
        • Hansson T.H.
        • Laerum E.
        • Brage S.
        • Eriksen H.R.
        • Holm S.H.
        • Svendsrod R.
        • Indahl A.
        Prevalence of low back pain and sickness absence: A “borderline” study in Norway and Sweden.
        Scand J Public Health. 2006; 34: 555-558
        • Isacson D.
        • Bingefors K.
        Epidemiology of analgesic use: a gender perspective.
        Eur J Anaesthesiol Suppl. 2002; 26: 5-15
        • Isselee H.
        • De Laat A.
        • Bogaerts K.
        • Lysens R.
        Long-term fluctuations of pressure pain thresholds in healthy men, normally menstruating women and oral contraceptive users.
        Eur J Pain. 2001; 5: 27-37
        • Jackson T.
        • Iezzi T.
        • Chen H.
        • Ebnet S.
        • Eglitis K.
        Gender, interpersonal transactions, and the perception of pain: An experimental analysis.
        J Pain. 2005; 6: 228-236
        • Jensen I.
        • Nygren A.
        • Gamberale F.
        • Goldie I.
        • Westerholm P.
        Coping with long-term musculoskeletal pain and its consequences: Is gender a factor?.
        Pain. 1994; 57: 167-172
        • Jensen I.B.
        • Bergstrom G.
        • Ljungquist T.
        • Bodin L.
        • Nygren A.L.
        A randomized controlled component analysis of a behavioral medicine rehabilitation program for chronic spinal pain: Are the effects dependent on gender?.
        Pain. 2001; 91: 65-78
        • Jensen M.T.
        • Petersen K.L.
        Gender differences in pain and secondary hyperalgesia after heat/capsaicin sensitization in healthy volunteers.
        J Pain. 2006; 7: 211-217
        • Ji Y.
        • Murphy A.Z.
        • Traub R.J.
        Estrogen modulation of morphine analgesia of visceral pain in female rats is supraspinally and peripherally mediated.
        J Pain. 2007; 8: 494-502
        • Jinks C.
        • Jordan K.
        • Croft P.
        Measuring the population impact of knee pain and disability with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
        Pain. 2002; 100: 55-64
        • Jinks C.
        • Jordan K.P.
        • Blagojevic M.
        • Croft P.
        Predictors of onset and progression of knee pain in adults living in the community: A prospective study.
        Rheumatology (Oxford). 2008; 47: 368-374
        • Joels C.S.
        • Mostafa G.
        • Matthews B.D.
        • Kercher K.W.
        • Sing R.F.
        • Norton H.J.
        • Heniford B.T.
        Factors affecting intravenous analgesic requirements after colectomy.
        J Am Coll Surg. 2003; 197: 780-785
        • Jones A.
        • Zachariae R.
        Gender, anxiety, and experimental pain sensitivity: An overview.
        J Am Med Womens Assoc. 2002; 57: 91-94
        • Jones A.
        • Zachariae R.
        Investigation of the interactive effects of gender and psychological factors on pain response.
        Br J Health Psychol. 2004; 9: 405-418
        • Jones A.
        • Zachariae R.
        • Arendt-Nielsen L.
        Dispositional anxiety and the experience of pain: Gender-specific effects.
        Eur J Pain. 2003; 7: 387-395
        • Kaiko R.F.
        • Wallenstein S.L.
        • Rogers A.G.
        • Houde R.W.
        Sources of variation in analgesic responses in cancer patients with chronic pain receiving morphine.
        Pain. 1983; 15: 191-200
        • Kallai I.
        • Barke A.
        • Voss U.
        The effects of experimenter characteristics on pain reports in women and men.
        Pain. 2004; 112: 142-147
        • Kankaanpaa M.
        • Taimela S.
        • Airaksinen O.
        • Hanninen O.
        The efficacy of active rehabilitation in chronic low back pain: Effect on pain intensity, self-experienced disability, and lumbar fatigability.
        Spine. 1999; 24: 1034-1042
        • Kawakami M.
        • Yoshioka E.
        • Konda N.
        • Arita J.
        • Visessuvan S.
        Data on the sites of stimulatory feedback action of gonadal steroids indispensable for luteinizing hormone release in the rat.
        Endocrinology. 1978; 102: 791-798
        • Kececi H.
        • Dener S.
        Epidemiological and clinical characteristics of migraine in Sivas, Turkey.
        Headache. 2002; 42: 275-280
        • Keefe F.J.
        • Affleck G.
        • France C.R.
        • Emery C.F.
        • Waters S.
        • Caldwell D.S.
        • Stainbrook D.
        • Hackshaw K.V.
        • Fox L.C.
        • Wilson K.
        Gender differences in pain, coping, and mood in individuals having osteoarthritic knee pain: A within-day analysis.
        Pain. 2004; 110: 571-577
        • Keefe F.J.
        • Lefebvre J.C.
        • Egert J.R.
        • Affleck G.
        • Sullivan M.J.
        • Caldwell D.S.
        The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: The role of catastrophizing.
        Pain. 2000; 87: 325-334
        • Keenan P.A.
        • Lindamer L.A.
        Non-migraine headache across the menstrual cycle in women with and without premenstrual syndrome.
        Cephalalgia. 1992; 12: 356-359
        • Kehlet H.
        • Jensen T.S.
        • Woolf C.J.
        Persistent postsurgical pain: Risk factors and prevention.
        Lancet. 2006; 367: 1618-1625
        • Keogh E.
        • Barlow C.
        • Mounce C.
        • Bond F.W.
        Assessing the relationship between cold pressor pain responses and dimensions of the anxiety sensitivity profile in healthy men and women.
        Cogn Behav Ther. 2006; 35: 198-206
        • Keogh E.
        • Bond F.W.
        • Hanmer R.
        • Tilston J.
        Comparing acceptance- and control-based coping instructions on the cold-pressor pain experiences of healthy men and women.
        Eur J Pain. 2005; 9: 591-598
        • Keogh E.
        • Eccleston C.
        Sex differences in adolescent chronic pain and pain-related coping.
        Pain. 2006; 123: 275-284
        • Keogh E.
        • Hamid R.
        • Hamid S.
        • Ellery D.
        Investigating the effect of anxiety sensitivity, gender and negative interpretative bias on the perception of chest pain.
        Pain. 2004; 111: 209-217
        • Keogh E.
        • Hatton K.
        • Ellery D.
        Avoidance versus focused attention and the perception of pain: Differential effects for men and women.
        Pain. 2000; 85: 225-230
        • Keogh E.
        • McCracken L.M.
        • Eccleston C.
        Do men and women differ in their response to interdisciplinary chronic pain management?.
        Pain. 2005; 114: 37-46
        • Kest B.
        • Sarton E.
        • Dahan A.
        Gender differences in opioid-mediated analgesia: Animal and human studies.
        Anesthesiology. 2000; 93: 539-547
        • Kim H.
        • Neubert J.K.
        • Rowan J.S.
        • Brahim J.S.
        • Iadarola M.J.
        • Dionne R.A.
        Comparison of experimental and acute clinical pain responses in humans as pain phenotypes.
        J Pain. 2004; 5: 377-384
        • Kim H.
        • Neubert J.K.
        • San M.A.
        • Xu K.
        • Krishnaraju R.K.
        • Iadarola M.J.
        • Goldman D.
        • Dionne R.A.
        Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament.
        Pain. 2004; 109: 488-496
        • Kjoller M.
        • Thoning H.
        Characteristics of non-response in the Danish Health Interview Surveys, 1987-1994.
        Eur J Public Health. 2005; 15: 528-535
        • Klosterhalfen S.
        • Enck P.
        Neurophysiology and psychobiology of the placebo response.
        Curr Opin Psychiatry. 2008; 21: 189-195
        • Koltyn K.F.
        • Trine M.R.
        • Stegner A.J.
        • Tobar D.A.
        Effect of isometric exercise on pain perception and blood pressure in men and women.
        Med Sci Sports Exerc. 2001; 33: 282-290
        • Komiyama O.
        • De Laat A.
        Tactile and pain thresholds in the intra- and extra-oral regions of symptom-free subjects.
        Pain. 2005; 115: 308-315
        • Komiyama O.
        • Kawara M.
        • De Laat A.
        Ethnic differences regarding tactile and pain thresholds in the trigeminal region.
        J Pain. 2007; 8: 363-369
        • Kowalczyk W.J.
        • Evans S.M.
        • Bisaga A.M.
        • Sullivan M.A.
        • Comer S.D.
        Sex differences and hormonal influences on response to cold pressor pain in humans.
        J Pain. 2006; 7: 151-160
        • Krogstad B.S.
        • Jokstad A.
        • Dahl B.L.
        • Vassend O.
        The reporting of pain, somatic complaints, and anxiety in a group of patients with TMD before and 2 years after treatment: Sex differences.
        J Orofacial Pain. 1996; 10: 263-269
        • Kroner-Herwig B.
        • Heinrich M.
        • Morris L.
        Headache in German children and adolescents: A population-based epidemiological study.
        Cephalalgia. 2007; 27: 519-527
        • Ku J.H.
        • Jeon Y.S.
        • Kim M.E.
        • Lee N.K.
        • Park Y.H.
        Psychological problems in young men with chronic prostatitis-like symptoms.
        Scand J Urol Nephrol. 2002; 36: 296-301
        • Kuba T.
        • Wu H.B.
        • Nazarian A.
        • Festa E.D.
        • Barr G.A.
        • Jenab S.
        • Inturrisi C.E.
        • Quinones-Jenab V.
        Estradiol and progesterone differentially regulate formalin-induced nociception in ovariectomized female rats.
        Horm Behav. 2006; 49: 441-449
        • Lacey R.J.
        • Thomas E.
        • Duncan R.C.
        • Peat G.
        Gender difference in symptomatic radiographic knee osteoarthritis in the Knee Clinical Assessment–CAS(K): A prospective study in the general population.
        BMC Musculoskel Disord. 2008; 9: 82
        • Lau H.
        • Patil N.G.
        Acute pain after endoscopic totally extraperitoneal (TEP) inguinal hernioplasty: Multivariate analysis of predictive factors.
        Surg Endosc. 2004; 18: 92-96
        • Laurell K.
        • Larsson B.
        • Eeg-Olofsson O.
        Prevalence of headache in Swedish schoolchildren, with a focus on tension-type headache.
        Cephalalgia. 2004; 24: 380-388
        • Lautenbacher S.
        • Krieg J.G.
        Pain perception in psychiatric disorders: a review of the literature.
        J Psychiatr Res. 1994; 28: 109-122
        • Lautenbacher S.
        • Nielsen J.
        • Andersen T.
        Arendt-Nielsen L:. Spatial summation of heat pain in males and females.
        Somatosens Mot Res. 2001; 18: 101-105
        • Lee O.Y.
        • Mayer E.A.
        • Schmulson M.
        • Chang L.
        • Naliboff B.
        Gender-related differences in IBS symptoms.
        Am J Gastroenterol. 2001; 96: 2184-2193
        • Lee S.Y.
        • Kim J.H.
        • Sung I.K.
        • Park H.S.
        • Jin C.J.
        • Choe W.H.
        • Kwon S.Y.
        • Lee C.H.
        • Choi K.W.
        Irritable bowel syndrome is more common in women regardless of the menstrual phase: A Rome II-based survey.
        J Korean Med Sci. 2007; 22: 851-854
        • Lee Y.C.
        • Wang H.P.
        • Chiu H.M.
        • Lin C.P.
        • Huang S.P.
        • Lai Y.P.
        • Wu M.S.
        • Chen M.F.
        • Lin J.T.
        Factors determining post-colonoscopy abdominal pain: Prospective study of screening colonoscopy in 1000 subjects.
        J Gastroenterol Hepatol. 2006; 21: 1575-1580
        • LeResche L.
        Epidemiology of temporomandibular disorders: implications for the investigation of etiologic factors.
        Crit Rev Oral Biol Med. 1997; 8: 291-305
        • LeResche L.
        Gender considerations in the epidemiology of chronic pain.
        in: Crombie I.K. Epidemiology of Pain. IASP Press, Seattle1999: 43-52
        • LeResche L.
        • Mancl L.
        • Sherman J.J.
        • Gandara B.
        • Dworkin S.F.
        Changes in temporomandibular pain and other symptoms across the menstrual cycle.
        Pain. 2003; 106: 253-261
        • LeResche L.
        • Mancl L.A.
        • Drangsholt M.T.
        • Saunders K.
        • Korff M.V.
        Relationship of pain and symptoms to pubertal development in adolescents.
        Pain. 2005; 118: 201-209
        • LeResche L.
        • Saunders K.
        • Von Korff M.R.
        • Barlow W.
        • Dworkin S.F.
        Use of exogenous hormones and risk of temporomandibular disorder pain.
        Pain. 1997; 69: 153-160
        • LeResche L.
        • Sherman J.J.
        • Huggins K.
        • Saunders K.
        • Mancl L.A.
        • Lentz G.
        • Dworkin S.F.
        Musculoskeletal orofacial pain and other signs and symptoms of temporomandibular disorders during pregnancy: a prospective study.
        J Orofac Pain. 2005; 19: 193-201
        • Levine F.M.
        • De Simone L.L.
        The effects of experimenter gender on pain report in male and female subjects.
        Pain. 1991; 44: 69-72
        • Lichten E.M.
        • Lichten J.B.
        • Whitty A.
        • Pieper D.
        The confirmation of a biochemical marker for women's hormonal migraine: The depo-estradiol challenge test.
        Headache. 1996; 36: 367-371
        • Liem M.S.
        • van Duyn E.B.
        • van der G.Y.
        • van Vroonhoven T.J.
        Recurrences after conventional anterior and laparoscopic inguinal hernia repair: A randomized comparison.
        Ann Surg. 2003; 237: 136-141
        • Lipton R.B.
        • Bigal M.E.
        • Diamond M.
        • Freitag F.
        • Reed M.L.
        • Stewart W.F.
        Migraine prevalence, disease burden, and the need for preventive therapy.
        Neurology. 2007; 68: 343-349
        • Lipton R.B.
        • Bigal M.E.
        • Steiner T.J.
        • Silberstein S.D.
        • Olesen J.
        Classification of primary headaches.
        Neurology. 2004; 63: 427-435
        • Lipton R.B.
        • Stewart W.F.
        • Diamond S.
        • Diamond M.L.
        • Reed M.
        Prevalence and burden of migraine in the United States: Data from the American Migraine Study II.
        Headache. 2001; 41: 646-657
        • Lomas L.M.
        • Terner J.M.
        • Picker M.J.
        Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a capsaicin model of persistent pain: Comparisons to two models of acute pain.
        Pharmacol Biochem Behav. 2008; 89: 127-136
        • Lookingland K.J.
        • Moore K.E.
        Effects of estradiol and prolactin on incertohypothalamic dopaminergic neurons in the male rat.
        Brain Res. 1984; 323: 83-91
        • Lovgren M.
        • Tishelman C.
        • Sprangers M.
        • Koyi H.
        • Hamberg K.
        Symptoms and problems with functioning among women and men with inoperable lung cancer: A longitudinal study.
        Lung Cancer. 2008; 60: 113-124
        • Lowery D.
        • Fillingim R.B.
        • Wright R.A.
        Sex differences and incentive effects on perceptual and cardiovascular responses to cold pressor pain.
        Psychosom Med. 2003; 65: 284-291
        • Lu C.L.
        • Chen C.Y.
        • Lang H.C.
        • Luo J.C.
        • Wang S.S.
        • Chang F.Y.
        • Lee S.D.
        Current patterns of irritable bowel syndrome in Taiwan: The Rome II questionnaire on a Chinese population.
        Aliment Pharmacol Ther. 2003; 18: 1159-1169
        • Lynch A.M.
        • Kashikar-Zuck S.
        • Goldschneider K.R.
        • Jones B.A.
        Sex and age differences in coping styles among children with chronic pain.
        J Pain Symptom Manage. 2007; 33: 208-216
        • Macfarlane T.V.
        • Blinkhorn A.
        • Worthington H.V.
        • Davies R.M.
        • Macfarlane G.J.
        Sex hormonal factors and chronic widespread pain: A population study among women.
        Rheumatology (Oxford). 2002; 41: 454-457
        • Manning A.P.
        • Thompson W.G.
        • Heaton K.W.
        • Morris A.F.
        Towards positive diagnosis of the irritable bowel.
        Br Med J. 1978; 2: 653-654
        • Mannino C.A.
        • South S.M.
        • Quinones-Jenab V.
        • Inturrisi C.E.
        Estradiol replacement in ovariectomized rats is antihyperalgesic in the formalin test.
        J Pain. 2007; 8: 334-342
        • Mannion A.F.
        • Junge A.
        • Taimela S.
        • Muntener M.
        • Lorenzo K.
        • Dvorak J.
        Active therapy for chronic low back pain, part 3: Factors influencing self-rated disability and its change following therapy.
        Spine. 2001; 26: 920-929
        • Marbach J.J.
        • Ballard G.T.
        • Frankel M.R.
        • Raphael K.G.
        Patterns of TMJ surgery: Evidence of sex differences.
        J Am Dental Assoc. 1997; 128 ([see comments]): 609-614
        • Marchand S.
        • Arsenault P.
        Odors modulate pain perception: A gender-specific effect.
        Physiol Behav. 2002; 76: 251-256
        • Marcus S.M.
        • Kerber K.B.
        • Rush A.J.
        • Wisniewski S.R.
        • Nierenberg A.
        • Balasubramani G.K.
        • Ritz L.
        • Kornstein S.
        • Young E.A.
        • Trivedi M.H.
        Sex differences in depression symptoms in treatment-seeking adults: Confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression study.
        Compr Psychiatry. 2008; 49: 238-246
        • Marklund S.
        • Wanman A.
        Incidence and prevalence of myofascial pain in the jaw-face region: A one-year prospective study on dental students.
        Acta Odontol Scand. 2008; 66: 113-121
        • Martikainen I.K.
        • Narhi M.V.
        • Pertovaara A.
        Spatial integration of cold pressor pain sensation in humans.
        Neurosci Lett. 2004; 361: 140-143
        • Mattila K.
        • Toivonen J.
        • Janhunen L.
        • Rosenberg P.H.
        • Hynynen M.
        Postdischarge symptoms after ambulatory surgery: First-week incidence, intensity, and risk factors.
        Anesth Analg. 2005; 101: 1643-1650
        • McEwen B.S.
        Invited review: Estrogens effects on the brain: Multiple sites and molecular mechanisms.
        J Appl Physiol. 2001; 91: 2785-2801
        • McEwen B.S.
        • Alves S.E.
        Estrogen actions in the central nervous system.
        Endocr Rev. 1999; 20: 279-307
        • McGrath P.A.
        Chronic pain in children.
        in: Crombie I.K. Epidemiology of Pain. IASP Press, Seattle1999: 81-101
        • McNally J.D.
        • Matheson D.A.
        • Bakowsky V.S.
        The epidemiology of self-reported fibromyalgia in Canada.
        Chronic Dis Can. 2006; 27: 9-16
        • McRoberts J.A.
        • Li J.
        • Ennes H.S.
        • Mayer E.A.
        Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neurons.
        Neuroscience. 2007; 21: 1015-1020
        • Merskey H.
        • Bogduk N.
        Classification of Chronic Pain.
        2nd edition. IASP Press, Seattle1994
        • Miaskowski C.
        Gender differences in pain, fatigue, and depression in patients with cancer.
        J Natl Cancer Inst Monogr 139-143. 2004;
        • Miaskowski C.
        • Levine J.D.
        Does opioid analgesia show a gender preference for females?.
        Pain Forum. 1999; 8: 34-44
        • Mikkelsson M.
        • Salminen J.J.
        • Kautiainen H.
        Non-specific musculoskeletal pain in preadolescents: Prevalence and 1-year persistence.
        Pain. 1997; 73: 29-35
        • Miller C.
        • Newton S.E.
        Pain perception and expression: The influence of gender, personal self-efficacy, and lifespan socialization.
        Pain Manag Nurs. 2006; 7: 148-152
        • Miller P.L.
        • Ernst A.A.
        Sex differences in analgesia: A randomized trial of mu versus kappa opioid agonists.
        South Med J. 2004; 97: 35-41
        • Miller V.M.
        • Duckles S.P.
        Vascular actions of estrogens: functional implications.
        Pharmacol Rev. 2008; 60: 210-241
        • Mitchell L.A.
        • MacDonald R.A.
        • Brodie E.E.
        A comparison of the effects of preferred music, arithmetic and humour on cold pressor pain.
        Eur J Pain. 2006; 10: 343-351
        • Mogil J.S.
        • Chanda M.L.
        The case for the inclusion of female subjects in basic science studies of pain.
        Pain. 2005; 117: 1-5
        • Mogil J.S.
        • Wilson S.G.
        • Chesler E.J.
        • Rankin A.L.
        • Nemmani K.V.
        • Lariviere W.R.
        • Groce M.K.
        • Wallace M.R.
        • Kaplan L.
        • Staud R.
        • Ness T.J.
        • Glover T.L.
        • Stankova M.
        • Mayorov A.
        • Hruby V.J.
        • Grisel J.E.
        • Fillingim R.B.
        The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans.
        Proc Natl Acad Sci U S A. 2003; 100 (4867–4862)
        • Moulton E.A.
        • Keaser M.L.
        • Gullapalli R.P.
        • Maitra R.
        • Greenspan J.D.
        Sex differences in the cerebral BOLD signal response to painful heat stimuli.
        Am J Physiol Regul Integr Comp Physiol. 2006; 291: R257-R267
        • Mozley L.H.
        • Gur R.C.
        • Mozley P.D.
        • Gur R.E.
        Striatal dopamine transporters and cognitive functioning in healthy men and women.
        Am J Psychiatry. 2001; 158: 1492-1499
        • Munce S.E.
        • Stewart D.E.
        Gender differences in depression and chronic pain conditions in a national epidemiologic survey.
        Psychosomatics. 2007; 48: 394-399
        • Musgrave D.S.
        • Vogt M.T.
        • Nevitt M.C.
        • Cauley J.A.
        Back problems among postmenopausal women taking estrogen replacement therapy.
        Spine. 2001; 26: 1606-1612
        • Myers C.D.
        • Riley III, J.L.
        • Robinson M.E.
        Psychosocial contributions to sex-correlated differences in pain.
        Clin J Pain. 2003; 19: 225-232
        • Myers C.D.
        • Robinson M.E.
        • Riley III, J.L.
        • Sheffield D.
        Sex, gender, and blood pressure: Contributions to experimental pain report.
        Psychosom Med. 2001; 63: 545-550
        • Nakai A.
        • Kumakura Y.
        • Boivin M.
        • Rosa P.
        • Diksic M.
        • D'Souza D.
        • Kersey K.
        Sex differences of brain serotonin synthesis in patients with irritable bowel syndrome using alpha-[11C]methyl-L-tryptophan, positron emission tomography and statistical parametric mapping.
        Can J Gastroenterol. 2003; 17: 191-196
        • Naliboff B.D.
        • Berman S.
        • Chang L.
        • Derbyshire S.W.
        • Suyenobu B.
        • Vogt B.A.
        • Mandelkern M.
        • Mayer E.A.
        Sex-related differences in IBS patients: Central processing of visceral stimuli.
        Gastroenterology. 2003; 124: 1738-1747
        • Nayak S.
        • Shiflett S.C.
        • Eshun S.
        • Levine F.M.
        Culture and gender effects in pain beliefs and the prediction of pain tolerance: Cross-Cultural Research.
        J Comparative Soc Sci. 2000; 34: 135-151
        • Nemmani K.V.
        • Grisel J.E.
        • Stowe J.R.
        • Smith-Carliss R.
        • Mogil J.S.
        Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: Dependence on sex, site of antagonism, morphine dose, and time.
        Pain. 2004; 109: 274-283
        • Nie H.
        • Arendt-Nielsen L.
        • Andersen H.
        • Graven-Nielsen T.
        Temporal summation of pain evoked by mechanical stimulation in deep and superficial tissue.
        J Pain. 2005; 6: 348-355
        • Nielsen C.S.
        • Stubhaug A.
        • Price D.D.
        • Vassend O.
        • Czajkowski N.
        • Harris J.R.
        Individual differences in pain sensitivity: Genetic and environmental contributions.
        Pain. 2008; 136: 21-29
        • Nikolajsen L.
        • Brandsborg B.
        • Lucht U.
        • Jensen T.S.
        • Kehlet H.
        Chronic pain following total hip arthroplasty: A nationwide questionnaire study.
        Acta Anaesthesiol Scand. 2006; 50: 495-500
        • Nyklicek I.
        • Vingerhoets A.J.
        • Van Heck G.L.
        Hypertension and pain sensitivity: Effects of gender and cardiovascular reactivity.
        Biol Psychol. 1999; 50: 127-142
        • Ockene J.K.
        • Barad D.H.
        • Cochrane B.B.
        • Larson J.C.
        • Gass M.
        • Wassertheil-Smoller S.
        • Manson J.E.
        • Barnabei V.M.
        • Lane D.S.
        • Brzyski R.G.
        • Rosal M.C.
        • Wylie-Rosett J.
        • Hays J.
        Symptom experience after discontinuing use of estrogen plus progestin.
        JAMA. 2005; 294: 183-193
        • Okifuji A.
        • Turk D.C.
        Sex hormones and pain in regularly menstruating women with fibromyalgia syndrome.
        J Pain. 2006; 7: 851-859
        • Oksuz E.
        Prevalence, risk factors, and preference-based health states of low back pain in a Turkish population.
        Spine. 2006; 31: E968-E972
        • Okunseri C.
        • Hodges J.S.
        • Born D.
        Self-reported toothache experience in an adult population in Benin City, Edo State, Nigeria.
        Oral Health Prev Dent. 2005; 3: 119-125
        • Olofsen E.
        • Romberg R.
        • Bijl H.
        • Mooren R.
        • Engbers F.
        • Kest B.
        • Dahan A.
        Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain.
        Anesthesiology. 2005; 103: 130-139
        • Omokhodion F.O.
        Low back pain in a rural community in South West Nigeria.
        West Afr J Med. 2002; 21: 87-90
        • Oshima M.
        • Ogawa R.
        • Londyn D.
        Current perception threshold increases during pregnancy but does not change across menstrual cycle.
        J Nippon Med Sch. 2002; 69: 19-23
        • Osman A.
        • Barrios F.X.
        • Gutierrez P.M.
        • Kopper B.A.
        • Merrifield T.
        • Grittmann L.
        The Pain Catastrophizing Scale: Further psychometric evaluation with adult samples.
        J Behav Med. 2000; 23: 351-365
        • Otto M.W.
        • Dougher M.J.
        Sex differences and personality factors in responsivity to pain.
        Percept Mot Skills. 1985; 61: 383-390
        • Overdad K.
        Epidemiological study design and measurement of associations.
        in: Olesen J. Headache Classification and Epidemiology. Raven Press, New York1994: 189-198
        • Ozan F.
        • Polat S.
        • Kara I.
        • Kucuk D.
        • Polat H.B.
        Prevalence study of signs and symptoms of temporomandibular disorders in a Turkish population.
        J Contemp Dent Pract. 2007; 8: 35-42
        • Pamuk O.N.
        • Cakir N.
        The variation in chronic widespread pain and other symptoms in fibromyalgia patients: The effects of menses and menopause.
        Clin Exp Rheumatol. 2005; 23: 778-782
        • Papageorgiou A.C.
        • Silman A.J.
        • Macfarlane G.J.
        Chronic widespread pain in the population: A seven year follow up study.
        Ann Rheum Dis. 2002; 61: 1071-1074
        • Paulson P.E.
        • Minoshima S.
        • Morrow T.J.
        • Casey K.L.
        Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans.
        Pain. 1998; 76: 223-229
        • Perquin C.W.
        • Hazebroek-Kampschreur A.A.
        • Hunfeld J.A.
        • Bohnen A.M.
        • van Suijlekom-Smit L.W.
        • Passchier J.
        • van der Wouden J.C.
        Pain in children and adolescents: A common experience.
        Pain. 2000; 87: 51-58
        • Petersen S.
        • Brulin C.
        • Bergstrom E.
        Recurrent pain symptoms in young schoolchildren are often multiple.
        Pain. 2006; 121: 145-150
        • Picavet H.S.
        • Hazes J.M.
        Prevalence of self reported musculoskeletal diseases is high.
        Ann Rheum Dis. 2003; 62: 644-650
        • Pinerua-Shuhaibar L.
        • Prieto-Rincon D.
        • Ferrer A.
        • Bonilla E.
        • Maixner W.
        • Suarez-Roca H.
        Reduced tolerance and cardiovascular response to ischemic pain in minor depression.
        J Affect Disord. 1999; 56: 119-126
        • Pool G.J.
        • Schwegler A.F.
        • Theodore B.R.
        • Fuchs P.N.
        Role of gender norms and group identification on hypothetical and experimental pain tolerance.
        Pain. 2007; 129: 122-129
        • Price D.D.
        • Hu J.W.
        • Dubner R.
        • Gracely R.H.
        Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses.
        Pain. 1977; 3: 57-68
        • Pud D.
        • Sprecher E.
        • Yarnitsky D.
        Homotopic and heterotopic effects of endogenous analgesia in healthy volunteers.
        Neurosci Lett. 2005; 380: 209-213
        • Pud D.
        • Yarnitsky D.
        • Sprecher E.
        • Rogowski Z.
        • Adler R.
        • Eisenberg E.
        Can personality traits and gender predict the response to morphine? An experimental cold pain study.
        Eur J Pain. 2006; 10: 103-112
        • Quiton R.L.
        • Greenspan J.D.
        Sex differences in endogenous pain modulation by distracting and painful conditioning stimulation.
        Pain. 2007; 132: S134-S149
        • Rauhala K.
        • Oikarinen K.S.
        • Jarvelin M.R.
        • Raustia A.M.
        Facial pain and temporomandibular disorders: An epidemiological study of the Northern Finland 1966 Birth Cohort.
        Cranio. 2000; 18: 40-46
        • Reyes-Gibby C.C.
        • Aday L.A.
        • Anderson K.O.
        • Mendoza T.R.
        • Cleeland C.S.
        Pain, depression, and fatigue in community-dwelling adults with and without a history of cancer.
        J Pain Symptom Manage. 2006; 32: 118-128
        • Rhudy J.L.
        • Meagher M.W.
        Noise stress and human pain thresholds: Divergent effects in men and women.
        J Pain. 2001; 2: 57-64
        • Rhudy J.L.
        • Williams A.E.
        Gender differences in pain: Do emotions play a role?.
        Gend Med. 2005; 2: 208-226
        • Riley III, J.L.
        • Gilbert G.H.
        Orofacial pain symptoms: An interaction between age and sex.
        Pain. 2001; 90: 245-256
        • Riley J.L.
        • Robinson M.E.
        • Wise E.A.
        • Myers C.D.
        • Fillingim R.B.
        Sex differences in the perception of noxious experimental stimuli: A meta-analysis.
        Pain. 1998; 74: 181-187
        • Riley J.L.I.
        • Robinson M.E.
        • Wise E.A.
        • Price D.D.
        A meta-analytic review of pain perception across the menstrual cycle.
        Pain. 1999; 81: 225-235
        • Ritter M.A.
        • Wing J.T.
        • Berend M.E.
        • Davis K.E.
        • Meding J.B.
        The clinical effect of gender on outcome of total knee arthroplasty.
        J Arthroplasty. 2008; 23: 331-336
        • Rivest R.
        • Falardeau P.
        • Di P.T.
        Brain dopamine transporter: Gender differences and effect of chronic haloperidol.
        Brain Res. 1995; 692: 269-272
        • Robin O.
        • Vinard H.
        • Vernet Maury E.
        • Saumet J.L.
        Influence of sex and anxiety on pain threshold and tolerance.
        Funct Neurol. 1987; 2: 173-179
        • Robinson M.E.
        • Dannecker E.A.
        • George S.Z.
        • Otis J.
        • Atchison J.W.
        • Fillingim R.B.
        Sex differences in the associations among psychological factors and pain report: A novel psychophysical study of patients with chronic low back pain.
        J Pain. 2005; 6: 463-470
        • Robinson M.E.
        • Gagnon C.M.
        • Riley III, J.L.
        • Price D.D.
        Altering gender role expectations: Effects on pain tolerance, pain threshold, and pain. ratings.
        J Pain. 2003; 4: 284-288
        • Robinson M.E.
        • Riley J.L.
        • Brown F.F.
        • Gremillion H.
        Sex differences in response to cutaneous anesthesia: A double blind randomized study.
        Pain. 1998; 77: 143-149
        • Robinson M.E.
        • Riley III, J.
        • Myers C.D.
        Psychosocial contributions to sex-related differences in pain responses.
        in: Fillingim R.B. Sex, Gender, and Pain. IASP Press, Seattle2000: 41-68
        • Robinson M.E.
        • Riley III, J.L.
        • Myers C.D.
        • Papas R.K.
        • Wise E.A.
        • Waxenberg L.A.
        • Fillingim R.B.
        Gender role expectations of pain: Relationship to sex differences in pain.
        J Pain. 2001; 2: 251-257
        • Robinson M.E.
        • Riley J.L.I.
        The role of emotion in pain.
        in: Gatchel R.J. Turk D.C. Psychosocial Factors in Pain. Guilford Press, New York1999: 74-88
        • Robinson M.E.
        • Wise E.A.
        • Gagnon C.
        • Fillingim R.B.
        • Price D.D.
        Influences of gender role and anxiety on sex differences in temporal summation of pain.
        J Pain. 2004; 5: 77-82
        • Roger V.L.
        • Farkouh M.E.
        • Weston S.A.
        • Reeder G.S.
        • Jacobsen S.J.
        • Zinsmeister A.R.
        • Yawn B.P.
        • Kopecky S.L.
        • Gabriel S.E.
        Sex differences in evaluation and outcome of unstable angina.
        JAMA. 2000; 283: 646-652
        • Rollman G.B.
        Gender differences in pain: Role of anxiety.
        Pain Forum. 1995; 4: 231-234
        • Rollman G.B.
        • Lautenbacher S.
        Sex differences in musculoskeletal pain.
        Clin J Pain. 2001; 17: 20-24
        • Romberg R.
        • Olofsen E.
        • Sarton E.
        • den H.J.
        • Taschner P.E.
        • Dahan A.
        Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: Absence of sex differences.
        Anesthesiology. 2004; 100: 120-133
        • Rosemann T.
        • Backenstrass M.
        • Joest K.
        • Rosemann A.
        • Szecsenyi J.
        • Laux G.
        Predictors of depression in a sample of 1,021 primary care patients with osteoarthritis.
        Arthritis Rheum. 2007; 57: 415-422
        • Rosen A.
        • Feldreich A.
        • Dabirian N.
        • Ernberg M.
        Effect of heterotopic noxious conditioning stimulation on electrical and pressure pain thresholds in two different anatomical regions.
        Acta Odontol Scand. 2008; 66: 181-188
        • Rosseland L.A.
        • Solheim N.
        • Stubhaug A.
        Pain and disability 1 year after knee arthroscopic procedures.
        Acta Anaesthesiol Scand. 2008; 52: 332-337
        • Rosseland L.A.
        • Stubhaug A.
        Gender is a confounding factor in pain trials: Women report more pain than men after arthroscopic surgery.
        Pain. 2004; 112: 248-253
        • Roth-Isigkeit A.
        • Thyen U.
        • Raspe H.H.
        • Stoven H.
        • Schmucker P.
        Reports of pain among German children and adolescents: An epidemiological study.
        Acta Paediatr. 2004; 93: 258-263
        • Ruda M.A.
        Gender and pain.
        Pain. 1993; 53 ([editorial]): 1-2
        • Russell M.B.
        • Levi N.
        • Saltyte-Benth J.
        • Fenger K.
        Tension-type headache in adolescents and adults: A population based study of 33,764 twins.
        Eur J Epidemiol. 2006; 21: 153-160
        • Rustoen T.
        • Fossa S.D.
        • Skarstein J.
        • Moum T.
        The impact of demographic and disease-specific variables on pain in cancer patients.
        J Pain Symptom Manage. 2003; 26: 696-704
        • Rustoen T.
        • Wahl A.K.
        • Hanestad B.R.
        • Lerdal A.
        • Paul S.
        • Miaskowski C.
        Gender differences in chronic pain: Findings from a population-based study of Norwegian adults.
        Pain Manag Nurs. 2004; 5: 105-117
        • Rutkiewicz T.
        • Kononen M.
        • Suominen-Taipale L.
        • Nordblad A.
        • Alanen P.
        Occurrence of clinical signs of temporomandibular disorders in adult Finns.
        J Orofac Pain. 2006; 20: 208-217
        • Ryan J.L.
        • Jureidini B.
        • Hodges J.S.
        • Baisden M.
        • Swift J.Q.
        • Bowles W.R.
        Gender differences in analgesia for endodontic pain.
        J Endod. 2008; 34: 552-556
        • Safran D.G.
        • Rogers W.H.
        • Tarlov A.R.
        • McHorney C.A.
        • Ware Jr., J.E.
        Gender differences in medical treatment: The case of physician-prescribed activity restrictions.
        Soc Sci Med. 1997; 45: 711-722
        • Salaffi F.
        • Leardini G.
        • Canesi B.
        • Mannoni A.
        • Fioravanti A.
        • Caporali R.
        • Lapadula G.
        • Punzi L.
        Reliability and validity of the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index in Italian patients with osteoarthritis of the knee.
        Osteoarthritis Cartilage. 2003; 11: 551-560
        • Sances G.
        • Granella F.
        • Nappi R.E.
        • Fignon A.
        • Ghiotto N.
        • Polatti F.
        • Nappi G.
        Course of migraine during pregnancy and postpartum: A prospective study.
        Cephalalgia. 2003; 23: 197-205
        • Sandler R.S.
        Epidemiology of irritable bowel syndrome in the United States.
        Gastroenterology. 1990; 99: 409-415
        • Sandroni P.
        • Benrud-Larson L.M.
        • McClelland R.L.
        • Low P.A.
        Complex regional pain syndrome type I: Incidence and prevalence in Olmsted county, a population-based study.
        Pain. 2003; 103: 199-207
        • Sanford S.D.
        • Kersh B.C.
        • Thorn B.E.
        • Rich M.A.
        • Ward L.C.
        Psychosocial mediators of sex differences in pain responsivity.
        J Pain. 2002; 3: 58-64
        • Sarlani E.
        • Farooq N.
        • Greenspan J.D.
        Gender and laterality differences in thermosensation throughout the perceptible range.
        Pain. 2003; 106: 9-18
        • Sarlani E.
        • Garrett P.H.
        • Grace E.G.
        • Greenspan J.D.
        Temporal summation of pain characterizes women but not men with temporomandibular disorders.
        J Orofac Pain. 2007; 21: 309-317
        • Sarlani E.
        • Grace E.G.
        • Reynolds M.A.
        • Greenspan J.D.
        Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation.
        Pain. 2004; 109: 115-123
        • Sarlani E.
        • Greenspan J.D.
        Gender differences in temporal summation of mechanically evoked pain.
        Pain. 2002; 97: 163-169
        • Sarton E.
        • Olofsen E.
        • Romberg R.
        • den Hartigh J.
        • Kest B.
        • Nieuwenhuijs D.
        • Burm A.
        • Teppema L.
        • Dahan A.
        Sex differences in morphine analgesia: An experimental study in healthy volunteers.
        Anesthesiology. 2000; 93: 1245-1254
        • Scher A.I.
        • Stewart W.F.
        • Lipton R.B.
        Migraine and headache: A meta-analytic approach.
        in: Crombie I.K. Epidemiology of Pain. IASP Press, Seattle1999: 159-170
        • Schmidt C.E.
        • Bestmann B.
        • Kuchler T.
        • Longo W.E.
        • Rohde V.
        • Kremer B.
        Gender differences in quality of life of patients with rectal cancer: A five-year prospective study.
        World J Surg. 2005; 29: 1630-1641
        • Schmidt C.O.
        • Raspe H.
        • Pfingsten M.
        • Hasenbring M.
        • Basler H.D.
        • Eich W.
        • Kohlmann T.
        Back pain in the German adult population: Prevalence, severity, and sociodemographic correlates in a multiregional survey.
        Spine. 2007; 32: 2005-2011
        • Schneider S.
        • Randoll D.
        • Buchner M.
        Why do women have back pain more than men? A representative prevalence study in the federal republic of Germany.
        Clin J Pain. 2006; 22: 738-747
        • Schulman K.A.
        • Berlin J.A.
        • Harless W.
        • Kerner J.F.
        • Sistrunk S.
        • Gersh B.J.
        • Dube R.
        • Taleghani C.K.
        • Burke J.E.
        • Williams S.
        • Eisenberg J.M.
        • Escarce J.J.
        The effect of race and sex on physicians' recommendations for cardiac catheterization.
        N Engl J Med. 1999; 25: 618-626
        • Schwartz B.S.
        • Stewart W.F.
        • Simon D.
        • Lipton R.B.
        Epidemiology of tension-type headache.
        JAMA. 1998; 279: 381-383
        • Serrao M.
        • Rossi P.
        • Sandrini G.
        • Parisi L.
        • Amabile G.A.
        • Nappi G.
        • Pierelli F.
        Effects of diffuse noxious inhibitory controls on temporal summation of the RIII reflex in humans.
        Pain. 2004; 112: 353-360
        • Sherman J.J.
        • LeResche L.
        Does experimental pain response vary across the menstrual cycle? A methodological review.
        Am J Physiol Regul Integr Comp Physiol. 2006; 291: R245-R256
        • Sherman J.J.
        • LeResche L.
        • Mancl L.A.
        • Huggins K.
        • Sage J.C.
        • Dworkin S.F.
        Cyclic effects on experimental pain response in women with temporomandibular disorders.
        J Orofac Pain. 2005; 19: 133-143
        • Shiotani A.
        • Miyanishi T.
        • Takahashi T.
        Sex differences in irritable bowel syndrome in Japanese university students.
        J Gastroenterol. 2006; 41: 562-568
        • Silverstein B.
        Gender differences in the prevalence of somatic versus pure depression: A replication.
        Am J Psychiatry. 2002; 159: 1051-1052