Abstract
Fibromyalgia (FM) is a chronic pain condition marked by centrally mediated augmentation
of pain and sensory processes. Skepticism has marked the history of this condition,
but more recent study has identified neurobiological underpinnings supporting many
of the symptoms associated with this condition. Early research in FM had unprecedented
latitude within the rheumatology community to borrow heavily from theory and methods
being applied in chronic pain research more generally. These insights facilitated
rapid advances in FM research, not the least of which was the abandonment of a peripheral
focus in favor of studying central mechanisms associated with central augmentation.
Currently, rapid-paced discovery is taking place in FM genetics, patient assessment,
new therapeutic targets, and novel methods of treatment delivery. Such insights are
not likely to be limited in application just to FM and could have relevance to the
broader field of pain research as well.
Perspective
This manuscript reviews the history of FM and its diagnosis, evidence supporting central
augmentation of pain in FM, potential mechanisms of central augmentation, current
approaches to integrated care of FM, and areas of active collaboration between FM
research and other chronic pain conditions.
Key words
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Footnotes
Editor's Note: This article is 1 in a series of invited Critical Review articles designed to celebrate The Journal of Pain's 10th year anniversary of publication.
Supported in part by grant numbers R01-AR050044 (NIAMS/NIH), AR053207 (NIAMS/NIH), U01AR55069 (NIAMS/NIH) and DAMD 17-00-2-0018 (Department of Defense).
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© 2009 American Pain Society. Published by Elsevier Inc. All rights reserved.
