Abstract
Development of tolerance, inadequate relief, and potential toxicity of classical antinociceptives
warrant the investigation of the newer agents to relieve diabetic neuropathic pain.
The aim of the present study was to explore the effect of sesamol on thermal and mechanical
hyperalgesia, allodynia, oxidative-nitrosative stress, inflammation, and apoptosis
in STZ-induced experimental diabetes. Diabetic rats developed neuropathy, which was
evident from a marked hyperalgesia and allodynia associated with enhanced nitrosative
stress, release of inflammatory mediators (TNF-α, IL-1β, TGF-1β), and caspase 3. Chronic
treatment with sesamol (2, 4, and 8 mg/kg body weight; po) for 4 weeks starting from
the 4th week of STZ injection significantly attenuated behavioral, biochemical, and
molecular changes associated with diabetic neuropathy. Moreover, diabetic rats treated
with insulin-sesamol combination produced more pronounced beneficial effect as compared
to their per se groups. The major finding of the study is that insulin alone corrected
the hyperglycemia and partially reversed the pain response in diabetic rats. However,
the combination with sesamol not only attenuated the diabetic condition but also reversed
neuropathic pain through modulation of oxidative-nitrosative stress, inflammatory
cytokine release, and caspase-3 in diabetic rats, and thus it may find clinical application
to treat neuropathic pain in the diabetic patient.
Perspective
This study shows the beneficial effect of sesamol on neuropathic pain through modulation
of oxidative-nitrosative stress, inflammatory cytokine release, and caspase-3 in diabetic
rats, and thus it may find clinical application to treat neuropathic pain in the diabetic
patient.
Key words
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Article info
Publication history
Published online: April 26, 2010
Accepted:
January 1,
2010
Received in revised form:
December 16,
2009
Received:
June 29,
2009
Footnotes
Supported by The Senior Research Fellowship (Anurag Kuhad) of the Indian Council of Medical Research (ICMR), New Delhi.
Identification
Copyright
© 2010 American Pain Society. Published by Elsevier Inc. All rights reserved.
