Abstract
We used multiple pain models to investigate the effects of (-)-linalool, a monoterpene
alcohol present in the essential oil of plants, on chronic inflammatory and neuropathic
hypersensitivity in adult Swiss mice. Inflammatory or neuropathic hypersensitivity
was induced by intraplantar (i.pl.) injection of complete Freund's adjuvant (CFA)
or partial sciatic nerve ligation (PSNL), respectively. Twenty-four hours after CFA
injection, we used Von Frey filaments and acetone-evoked cooling to evaluate tactile
and thermal hypersensitivity, respectively. A single i.p. injection of (-)-linalool
(50 or 200 mg/kg) administered 30 minutes before testing reduced CFA-induced mechanical
hypersensitivity. Similarly, (-)-linalool reduced acetone-evoked hypersensitivity
up to 4 hours after treatment. Compared with vehicle, (-)-linalool produced a marked
reduction in CFA-induced paw edema. (-)-Linalool also reduced mechanical hypersensitivity
induced by PSNL 7 days after injury. Multiple (-)-linalool treatments given chronically
(twice a day for 10 days; 50 mg/kg, i.p.) significantly reduced mechanical hypersensitivity
induced by CFA and PSNL. This multidose strategy did not cause tolerance. We also
reasoned that (-)-linalool might reduce nociceptive behavior in response to direct
administration of inflammatory mediators. Therefore, we injected the cytokines IL-1β
(.1 pg/site) and TNF-α (1 pg/site) intrathecally. (-)-Linalool inhibited the biting
response induced by IL-1β and TNF-α.
Perspective
The article adds information about antinociceptive properties of (-)-linalool in chronic
inflammatory and neuropathic hypersensitivity. It also indicates that (-)-linalool
might be potentially interesting in the development of new clinically relevant drugs
for the management of persistent pain.
Key words
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Article info
Publication history
Published online: May 10, 2010
Accepted:
February 26,
2010
Received in revised form:
February 11,
2010
Received:
September 3,
2009
Footnotes
Supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior (CAPES), Programa de Apoio aos Núcleos de Excelência (PRONEX), Fundação de Apoio à Pesquisa Científica Tecnológica do Estado de Santa Catarina (FAPESC), and Financiadora de Estudos e Projetos [FINEP, Rede Instituto Brasileiro de Neurociência (IBN-Net)], Brazil.
Identification
Copyright
© 2010 American Pain Society. Published by Elsevier Inc. All rights reserved.
