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Central Sensitization Versus Synaptic Long-Term Potentiation (LTP): A Critical Comment

      I read with interest the chapter, “Activity-Dependent Central Sensitization and Synaptic Plasticity,” in the recent review article by Latrémolière and Woolf
      • Latremoliere A.
      • Woolf C.J.
      Central sensitization: A generator of pain hypersensitivity by central neural plasticity.
      in The Journal of Pain. I noticed a number of issues in that chapter which deserve some discussion. These include the concept of synaptic long-term potentiation in pain pathways and its relation to the more general phrase “central sensitization.”
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