Abstract
Hypertension-associated hypoalgesia is widely recognized in acute pain conditions.
In chronic pain states, however, the relationship between blood pressure and pain
sensitivity is still ill-defined, with different authors reporting negative, positive,
or even no relationship at all. This work addresses this issue, using complete Freund's
adjuvant (CFA)-induced monoarthritis in different models of hypertension: Spontaneous
(spontaneously hypertensive rats, SHR), induced by infusion of angiotensin II (ANG)
or 1,3-dipropyl-8-sulfophenylxanthine (DPSPX, an adenosine receptors' antagonist),
and renal artery ligation (RAL). Nociceptive responses associated with monoarthritis
were evaluated by different behavioral tests (von Frey, ankle-bend and CatWalk) and
by quantification of Fos expression at the dorsal horn upon noxious stimulation. In
all hypertension models, higher von Frey thresholds and lower Fos expression were
detected in hypertensive rats with chronic inflammatory pain, as compared to normotensive
monoarthritic rats. In SHR and DPSPX, but not ANG or RAL models, hypertensive animals
displayed lower inflammation than normotensives. Ankle-bend and CatWalk results indicated
lower pain sensitivity in hypertensive rats only in SHR and DPSPX models. The present
study shows the importance of using multiple models of hypertension, and evaluating
pain responses by various methods, to better understand the complexity of the interactions
between pain and cardiovascular regulatory systems.
Perspective
This study used different models of hypertension to investigate whether chronic pain
alters the normal integration of cardiovascular and pain regulatory systems. A complete
understanding of the mechanisms underlying the complex interactions between these
systems may disclose future therapeutic approaches to treat hypertension/chronic pain
comorbidity states.
Key words
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Article info
Publication history
Published online: August 26, 2010
Accepted:
June 24,
2010
Received in revised form:
April 23,
2010
Received:
March 1,
2010
Footnotes
Supported by the project POCTI/NSE/45409/2002 of FCT.
Identification
Copyright
© 2011 American Pain Society. Published by Elsevier Inc. All rights reserved.
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- ErratumThe Journal of PainVol. 17Issue 4
- PreviewIncorrect grant funding information was published in Pinho D, Morato M, Couto MR, Marques-Lopes J, Tavares I, Albino-Teixeira A: Does chronic pain alter the normal interaction between cardiovascular and pain regulatory systems? Pain modulation in the hypertensive-monoarthritic rat. J Pain 12:194-204, 2011. The corrected information appears below:
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