Advertisement
Original Report| Volume 12, ISSUE 2, P272-279, February 2011

Download started.

Ok

A Randomized Clinical Trial of Acupuncture Versus Oral Steroids for Carpal Tunnel Syndrome: A Long-Term Follow-Up

Published:November 29, 2010DOI:https://doi.org/10.1016/j.jpain.2010.09.001

      Abstract

      We prospectively followed up patients with carpal tunnel syndrome (CTS) in our previous study for 1 year. A total of 77 consecutive patients with electrophysiologically confirmed mild-to-moderate idiopathic CTS were randomized and assigned into 2 treatment arms: 1) 2 weeks of prednisolone 20 mg daily followed by 2 weeks of prednisolone 10 mg daily (n = 39); and 2) acupuncture administered in 8 sessions over 4 weeks (n = 38). In the current study, the patients were further followed up at 7 and 13 months using Global symptom score (GSS) assessments and nerve conduction studies repeated again at 13 months. When comparing with baseline levels, the percentages of patients with treatment failure, moderate improvement, and good improvement were significantly different between the 2 groups at month 7 [10.5, 2.6, and 86.8% for the acupuncture group and 33.3, 7.7, and 59% for the steroid group, respectively (P = .014)] and month 13 [15.8, 2.6, and 81.6% versus 51.3, 0, and 48.7%, respectively (P = .002)]. The acupuncture group had a significantly better improvement in GSS, distal motor latencies and distal sensory latencies when compared to the steroid group throughout the 1-year follow-up period (P < .01). Furthermore, significant correlation was observed between changes of GSS (month 13–baseline) and all parameters of the electrophysiological assessments except for compound muscle action potential amplitude.

      Perspective

      This article demonstrates that short-term acupuncture treatment may result in long-term improvement in mild-to-moderate idiopathic CTS. Acupuncture treatment can be considered as an alternative therapy to other conservative treatments for those who do not opt for early surgical decompression.

      Key words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The Journal of Pain
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bland J.D.
        Treatment of carpal tunnel syndrome.
        Muscle Nerve. 2007; 36: 167-171
        • Cabyoglu M.T.
        • Ergene N.
        • Tan U.
        The mechanism of acupuncture and clinical applications.
        Int J Neurosci. 2006; 116: 115-125
        • Chang M.H.
        • Chiang H.T.
        • Lee S.S.
        • Ger L.P.
        • Lo Y.K.
        Oral drug of choice in carpal tunnel syndrome.
        Neurology. 1998; 51: 390-393
        • Chang M.H.
        • Ger L.P.
        • Hsieh P.F.
        • Huang S.Y.
        A randomized clinical trial of oral steroids in the treatment of carpal tunnel syndrome: A long-term follow up.
        J Neurol Neurosurg Psychiatry. 2002; 73: 710-714
        • Chang M.H.
        • Liu L.H.
        • Lee Y.C.
        • Hsieh P.F.
        Comparison of sensitivity of transcarpal median motor conduction velocity and conventional conduction techniques in electrodiagnosis of carpal tunnel syndrome.
        Clin Neurophysiology. 2006; 117: 984-991
        • Dorwart B.B.
        Carpal tunnel syndrome: A review.
        Semin Arthritis Rheum. 1984; 14: 134-140
        • Gelberman R.H.
        • Rydevik B.L.
        • Pess G.M.
        • Szabo R.M.
        • Lundborg G.
        Carpal tunnel syndrome: A scientific basis for clinical care.
        Orthop Clin North Am. 1988; 19: 115-124
        • Gerritsen A.A.
        • de Krom M.C.
        • Struijs M.A.
        • Scholten R.J.
        • de Vet H.C.
        • Bouter L.M.
        Conservative treatment options for carpal tunnel syndrome: A systematic review of randomized controlled trials.
        J Neurol. 2002; 249: 272-280
        • Gerritsen A.A.
        • de Vet H.C.
        • Scholten R.J.
        • Bertelsmann F.W.
        • de Krom M.C.
        • Bouter L.M.
        Splinting vs surgery in the treatment of carpal tunnel syndrome: A randomized controlled trial.
        JAMA. 2002; 228: 1245-1251
        • Hakim A.J.
        • Cherkas L.
        • El Zayat S.
        • MacGregor A.J.
        • Spector T.D.
        The genetic contribution to carpal tunnel syndrome in women: A twin study.
        Arthritis Rheum. 2002; 47: 275-279
        • Herskovitz S.
        • Berger A.R.
        • Lipton R.B.
        Low-dose, short-term oral prednisone in the treatment of carpal tunnel syndrome.
        Neurology. 1995; 45: 1923-1925
        • Hui A.C.
        • Wong S.
        • Leung C.H.
        • Tong P.
        • Mok V.
        • Poon D.
        • Li-Tsang C.W.
        • Wong L.K.
        • Boet R.
        A randomized controlled trial of surgery vs. steroid injection for carpal tunnel syndrome.
        Neurology. 2005; 64: 2074-2078
        • Hui A.C.
        • Wong S.M.
        • Wong K.S.
        • Li E.
        • Kay R.
        • Yung P.
        • Hung L.K.
        • Yu L.M.
        Oral steroids in the treatment of carpal tunnel syndrome.
        Ann Rheum Dis. 2001; 60: 813-814
        • Hui K.K.
        • Liu J.
        • Makris N.
        • Gollub R.L.
        • Chen A.J.
        • Moore C.I.
        • Kennedy D.N.
        • Rosen B.R.
        • Kwong K.K.
        Acupuncture modulates the limbic system and subcortical gray structures of the human brain: Evidence from fMRI studies in normal subjects.
        Hum Brain Mapp. 2000; 9: 13-25
        • Jablecki C.K.
        • Andary M.T.
        • Floeter M.K.
        • Miller R.G.
        • Quartly C.A.
        • Vennix M.J.
        • Wilson J.R.
        Practice parameter: Electrodiagnostic studies in carpal tunnel syndrome. Report of the American Association of Electrodiagnostic Medicine, American Academy of Neurology, and the American Academy of Physical Medicine and Rehabilitation.
        Neurology. 2002; 58: 1589-1592
        • Jablecki C.K.
        • Andary M.T.
        • So Y.T.
        • Wilkins D.E.
        • Williams F.H.
        Literature review of the usefulness of nerve conduction studies and electromyography for the evaluation of patients with carpal tunnel syndrome.
        Muscle Nerve. 1993; 16: 1392-1414
        • Kaptchuk T.J.
        Acupuncture: Theory, efficacy, and practice.
        Ann Intern Med. 2002; 136: 374-383
        • Kavoussi B.
        • Ross B.E.
        The neuroimmune basis of anti-inflammatory acupuncture.
        Integr Cancer Ther. 2007; 6: 251-257
        • Keir P.J.
        • Rempel D.M.
        Pathomechanics of peripheral nerve loading. Evidence in carpal tunnel syndrome.
        J Hand Ther. 2005; 18: 259-269
        • Lundeberg T.
        Peripheral effects of sensory nerve stimulation (acupuncture) in inflammation and ischemia.
        Scand J Rehabil Med Suppl. 1993; 29: 61-86
        • Marshall S.
        • Tardif G.
        • Ashworth N.
        Local corticosteroid injection for carpal tunnel syndrome.
        Cochrane Database Syst Rev. 2007; 18: CD001554
        • Muller M.
        • Tsui D.
        • Schnurr R.
        • Biddulph-Deisroth L.
        • Hard J.
        • MacDermid J.C.
        Effectiveness of hand therapy interventions in primary management of carpal tunnel syndrome: a systematic review.
        J Hand Ther. 2004; 17: 210-228
        • Michalsen A.
        • Bock S.
        • Lüdtke R.
        • Rampp T.
        • Baecker M.
        • Bachmann J.
        • Langhorst J.
        • Musial F.
        • Dobos G.J.
        Effects of traditional cupping therapy in patients with carpal tunnel syndrome: A randomized controlled trial.
        J Pain. 2009; 10: 601-608
        • Napadow V.
        • Kettner N.
        • Liu J.
        • Li M.
        • Kwong K.K.
        • Vangel M.
        • Makris N.
        • Audette J.
        • Hui K.K.
        Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome.
        Pain. 2007; 130: 254-266
        • O’Connor D.
        • Marshall S.
        • Massy-Westropp N.
        Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome.
        Cochrane Database Syst Rev:CD003219. 2003;
        • Oken B.S.
        Placebo effects: Clinical aspects and neurobiology.
        Brain. 2008; 131: 2812-2823
        • Ortiz-Corredor F.
        • Enríquez F.
        • Díaz-Ruíz J.
        • Calambas N.
        Natural evolution of carpal tunnel syndrome in untreated patients.
        Clin Neurophysiol. 2008; 119: 1373-1378
        • Padua L.
        • Padua R.
        • Aprile I.
        • Pasqualetti P.
        • Tonali P.
        Multiperspective follow-up of untreated carpal tunnel syndrome: A multicenter study.
        Neurology. 2001; 56: 1459-1466
        • Piazzini D.B.
        • Aprile I.
        • Ferrara P.E.
        • Bertolini C.
        • Tonali P.
        • Maggi L.
        • Rabini A.
        • Piantelli S.
        • Padua L.
        A systematic review of conservative treatment of carpal tunnel syndrome.
        Clin Rehabil. 2007; 21: 299-314
        • Rempel D.
        • Dahlin L.
        • Lundborg G.
        Pathophysiology of nerve compression syndromes: Response of peripheral nerves to loading.
        J Bone Joint Surg Am. 1999; 81: 1600-1610
        • Scanlon A.
        • Maffei J.
        Carpal tunnel syndrome.
        J Neurosci Nurs. 2009; 41: 140-147
        • Schröder S.
        • Liepert J.
        • Remppis A.
        • Greten J.H.
        Acupuncture treatment improves nerve conduction in peripheral neuropathy.
        Eur J Neurol. 2007; 14: 276-281
        • Seiler 3rd, J.G.
        • Milek M.A.
        • Carpenter G.K.
        • Swiontkowski M.F.
        Intraoperative assessment of median nerve blood flow during carpal tunnel release with laser Doppler flowmetry.
        J Hand Surg Am. 1989; 14: 986-991
        • Tsuchiya M.
        • Sato E.F.
        • Inoue M.
        • Asada A.
        Acupuncture enhances generation of nitric oxide and increases local circulation.
        Anesth Analg. 2007; 104: 301-307
        • Tucci M.A.
        • Barbieri R.A.
        • Freeland A.E.
        Biochemical and histological analysis of the flexor tenosynovium in patients with carpal tunnel syndrome.
        Biomed Sci Instrum. 1997; 33: 246-251
        • Werner R.A.
        • Andary M.
        Carpal tunnel syndrome: Pathophysiology and clinical neurophysiology.
        Clin Neurophysiol. 2002; 113: 1373-1381
        • Wilder-Smith E.P.
        • Lirong L.
        • Seet R.C.
        • Lim E.C.
        Symptoms associated with electrophysiologically verified carpal tunnel syndrome in Asian patients.
        J Hand Surg Br. 2006; 31: 326-330
        • Wilson J.K.
        • Sevier T.L.
        A review of treatment for carpal tunnel syndrome.
        Disabil Rehabil. 2003; 25: 113-119
        • Wu M.T.
        • Hsieh J.C.
        • Xiong J.
        • Yang C.F.
        • Pan H.B.
        • Chen Y.C.
        • Tsai G.
        • Rosen B.R.
        • Kwong K.K.
        Central nervous pathway for acupuncture stimulation: Localization of processing with functional MR imaging of the brain–preliminary experience.
        Radiology. 1999; 212: 133-141
        • Yang C.P.
        • Hsieh C.L.
        • Wang N.H.
        • Li T.C.
        • Hwang K.L.
        • Yu S.C.
        • Chang M.H.
        Acupuncture in patients with carpal tunnel syndrome: A randomized controlled trial.
        Clin J Pain. 2009; 25: 327-333
        • Zhang W.
        • Robertson J.
        • Jones A.C.
        • Dieppe P.A.
        • Doherty M.
        The placebo effect and its determinants in osteoarthritis: Meta-analysis of randomised controlled trials.
        Ann Rheum. 2008; 67: 1716-1723
        • Zijlstra F.J.
        • van den Berg-de Lange I.
        • Huygen F.J.
        • Klein J.
        Anti-inflammatory actions of acupuncture.
        Mediators Inflamm. 2003; 12: 59-69