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- The GDNF family: Signalling, biological functions and therapeutic value.Nat Rev Neurosci. 2002; 3: 383-394
- NGF and GDNF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia.Eur J Neurosci. 2004; 20: 2303-2310
- NGF and GDNF ameliorate the increase in ATF3 expression which occurs in dorsal root ganglion cells in response to peripheral nerve injury.Eur J Neurosci. 2004; 19: 1437-1445
- Cellular and molecular mechanisms of pain.Cell. 2009; 139: 267-284
- The glial cell line-derived neurotrophic factor family receptor components are differentially regulated within sensory neurons after nerve injury.J Neurosci. 2000; 20: 427-437
- A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury.J Neurosci. 1998; 18: 3059-3072
- GDNF hyperalgesia is mediated by PLCγ, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.Eur J Neurosci. 2008; 28: 12-19
- Potent analgesic effects of GDNF in neuropathic pain states.Science. 2000; 290: 124-127
- The expression of P2X3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor.Mol Cell Neurosci. 1998; 12: 256-268
- GDNF is an age-specific survival factor for sensory and autonomic neurons.Neuron. 1995; 15: 821-828
- Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.Proc Natl Acad Sci U S A. 2009; 106: 9075-9080
- Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons.Brain Res. 2009; 1284: 54-67
- High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons.Mol Cell Neurosci. 2003; 24: 106-116
- Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: A putative ribosomal ‘skip’.J Gen Virol. 2001; 82: 1013-1025
- Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model.Eur J Neurosci. 2005; 22: 2587-2595
- Glial cell line-derived neurotrophic factor contributes to delayed inflammatory hyperalgesia in adjuvant rat pain model.Neuroscience. 2003; 117: 503-512
- Recombinant AAV vectors containing the foot and mouth disease virus 2A sequence confer efficient bicistronic gene expression in cultured cells and rat substantia nigra neurons.Gene Ther. 2001; 8: 864-873
- RET signaling is required for survival and normal function of nonpeptidergic nociceptors.J Neurosci. 2010; 30: 3983-3994
- Mobilization and mechanism of transcription of integrated self-inactivating lentiviral vectors.J Virol. 2005; 79: 8410-8421
- HSV-mediated gene transfer of the glial cell-derived neurotrophic factor provides an antiallodynic effect on neuropathic pain.Mol Ther. 2003; 8: 367-375
- Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation.Eur J Neurosci. 2004; 20: 1705-1712
- Peripheral contributions to the mechanical hyperalgesia following a lumbar 5 spinal nerve lesion in rats.Neuroscience. 2010; 165: 221-232
- An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.Pain. 1992; 50: 355-363
- Upregulation of bradykinin B2 receptor expression by neurotrophic factors and nerve injury in mouse sensory neurons.Mol Cell Neurosci. 2002; 19: 186-200
- Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers.Pain. 2000; 85: 493-502
- Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model.Brain Res. 2000; 871: 98-103
- A novel control mechanism based on GDNF modulation of somatostatin release from sensory neurones.FASEB J. 2002; 16: 730-732
- Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo.J Neurosci. 2006; 26: 8588-8599
- Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington’s disease.Proc Natl Acad Sci U S A. 2006; 103: 9345-9350
- Role of glial cell line-derived neurotrophic factor (GDNF)-neural cell adhesion molecule (NCAM) interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF.J Neurosci. 2009; 29: 11360-11376
- Immunolocalization of the neural cell adhesion molecule L1 in epithelia of rodents.Cell Tissue Res. 1999; 298: 261-273
- Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats.Pain. 2003; 101: 65-77
- Ultrastructural study of anterograde transport of glial cell line-derived neurotrophic factor from dorsal root ganglion neurons of rats towards the nerve terminal.Cells Tissues Organs. 2001; 169: 410-421
- GDNF and GFRα: A versatile molecular complex for developing neurons.Trends Neurosci. 2008; 31: 384-391
- The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands.Cell. 2003; 113: 867-879
- Reversal of neurochemical changes and pain-related behavior in a model of neuropathic pain using modified lentiviral vectors expressing GDNF.Mol Ther. 2006; 13: 1101-1109
- RET ligand-induced internalization and its consequences for downstream signaling.Oncogene. 2006; 25: 3206-3211
- Anterograde axonal transport of internalized GDNF in sensory and motor neurons.Neuroreport. 2002; 13: 659-664
- Involvement of neural cell adhesion molecule signaling in glial cell line-derived neurotrophic factor-induced analgesia in a rat model of neuropathic pain.Pain. 2008; 137: 378-388
- Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.Cell. 2009; 137: 1148-1159
- Key role of the dorsal root ganglion in neuropathic tactile hypersensibility.Eur J Pain. 2004; 8: 135-143
- Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral nerve injury.Neuroscience. 2006; 141: 1233-1245
- The behavioral and neuroanatomical effects of IB4-saporin treatment in rat models of nociceptive and neuropathic pain.Brain Res. 2004; 1029: 65-76
- Neuronal circuitry for pain processing in the dorsal horn.Nat Rev Neurosci. 2010; 11: 823-836
- Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF.J Physiol. 2004; 560: 391-401
- Glial cell line-derived neurotrophic factor normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain.Neuroscience. 2003; 121: 815-824
Wu G, Ringkamp M, Hartke TV, Murinson BB, Campbell JN, Griffin JW, Meyer RA: Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers. J Neurosci 21:140RC-2001
- Ethical guidelines for investigations of experimental pain in conscious animals.Pain. 1983; 16: 109-110
- Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse.J Neurosci. 2002; 22: 4057-4065
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Supported by a Grant-in-Aid for Encouragement of Young Scientists (B) (22791457 to A.S.) from the Japan Society for the Promotion of Science and a grant (S0801035 to H.S.) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.