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Reply to Drs. Loeser and Mogil

      I thank my colleagues for their remarks and I am pleased that we agree on the usefulness of reassessing our terminology and for the need for research into the question of the role of stimulus-evoked pain and its summation as potential contributors to the pain patient's experience of persistent daily pain.
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      Linked Article

      • Chronic Pain Is More Than a Peripheral Event
        The Journal of PainVol. 13Issue 10
        • Preview
          Bennett’s focus article makes 2 important contributions: 1 philosophical and the other physiological. “Spontaneous” is, of course, an absurd term to use in the description of a physiologic process.1 It is reminiscent of another odious term, “idiopathic,” which my grandfather told me was “idiotic for the physician and pathetic for the patient.” If one believes that a process is “spontaneous,” then there is no reason to search for explanatory mechanisms. It has long been recognized that words constrain thought, so Bennett is correct in his attack on this term.
        • Full-Text
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      • The Etiology and Symptomatology of Spontaneous Pain
        The Journal of PainVol. 13Issue 10
        • Preview
          Recent years have witnessed a large number of failed analgesic drug trials, and in the subsequent soul-searching, 2 potential (and likely mutually exclusive) explanations have gained traction: either that clinical trials are failing to show efficacy of actually effective compounds,3 or that preclinical pain science's almost exclusive focus on reflexive withdrawal measures has failed to accurately model clinical pain, leading to the development of largely ineffective compounds.7,9 A solution to the latter problem is to instead measure “spontaneous pain,” and a number of new methodologies to accomplish this have been recently developed or rediscovered.
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