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Stephen F. Butler, Theresa A. Cassidy, Ryan A. Black, and Simon H. Budman are employees of Inflexxion, Inc. Stephen F. Butler and Simon H. Budman are shareholders of Inflexxion, Inc.
Howard Chilcoat, Craig Landau, and Paul Coplan are employees of Purdue Pharma LP.
Preparation of this article was supported in part by Inflexxion, Inc, Newton, MA, and Purdue Pharma LP, Stamford, CT. The authors had sole editorial rights over the manuscript.