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Pain, mood, and functional status in youth with sickle cell disease hospitalized for pain

      Youth with sickle cell disease (SCD) are frequently hospitalized for severe episodes of pain. As part of a validation study of a new acute pain functional assessment tool we collected data at a single time point during hospitalization on a sample consisting of 159 unique SCD patients (55.3% female, 86% African American, 67% Hgb SS), ages 7-21 years (M=15.73, SD=3.63) who were admitted for vaso-occlusive episode at four urban children hospitals in the eastern United States. In this sample we describe current pain intensity, functional motor status (Functional Independence Measure; FIM), and mood (Positive Affect-Negative Affect Scale for Children; PANAS-C) as well as pain burden (Sickle Cell Pain Burden Interview-Youth; SCBPI-Y), functional status (Child Activity Limitations Interview; CALI), and quality of life (Pediatric Quality of Life Inventory; PedsQL) over the previous four weeks. Regarding the measures, the average self-report pain rating was 5.86 (SD=2.14; range 0-9.80), current function on the FIM motor scale was 56.64 (SD=15.23; range=21-91) and the average score for the PANAS-C Positive Affect was 26.52 (SD=11.00; range=12-56). For the previous 4 weeks the SCPBI-Y average score was 10.53 (SD=5.53; range=0-23), the average score for the CALI was 23.96 (SD=17.56; range=0-70.41) and the PedsQL average score was 61.65 (SD=17.05; range=14.13-100). Youth with SCD experienced moderate pain and as well as moderate reduction in function and mood at the time of hospitalization. In the weeks leading up to hospitalization the subjects also experienced reduced functional ability, quality of life and increased pain burden. Further analysis will focus on understanding the relationships between pain, function and mood in youth with SCD hospitalized for pain.