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Letters to the Editor| Volume 14, ISSUE 9, P999, September 2013

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Using Sherlock and ClinicalTrials.gov Data to Understand Nocebo Effects and Adverse Event Dropout Rates in the Placebo Arm

      We appreciate Dr Quessy's insightful comments. We used Sherlock
      • Cepeda M.S.
      • Lobanov V.
      • Berlin J.A.
      From ClinicalTrials.gov trial registry to an analysis-ready database of clinical trial results.
      to download data from ClinicalTrials.gov and to illustrate the value of those data.
      • Cepeda M.S.
      • Lobanov V.
      • Berlin J.A.
      Use of ClinicalTrials.gov to estimate condition-specific nocebo effects and other factors affecting outcomes of analgesic trials.
      Therefore, we are pleased to see discussion on the implications of the study findings.
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      References

        • Cepeda M.S.
        • Berlin J.A.
        • Gao C.Y.
        • Wiegand F.
        • Wada D.R.
        Placebo response changes depending on the neuropathic pain syndrome: Results of a systematic review and meta-analysis.
        Pain Med. 2012; 13: 575-595
        • Cepeda M.S.
        • Lobanov V.
        • Berlin J.A.
        From ClinicalTrials.gov trial registry to an analysis-ready database of clinical trial results.
        Clin Trials. 2013; 10: 347-348
        • Cepeda M.S.
        • Lobanov V.
        • Berlin J.A.
        Use of ClinicalTrials.gov to estimate condition-specific nocebo effects and other factors affecting outcomes of analgesic trials.
        J Pain. 2013; 14: 405-411

      Linked Article

      • How Should We Interrogate the ClinicalTrials.gov Database?
        The Journal of PainVol. 14Issue 9
        • Preview
          The recently published article by Cepeda et al compiling pain trial data from the ClinicalTrials.gov database is important for the large number of randomized trials summarized (>7,000 trials).1 Much of the analysis focuses on attrition. However, several issues arising from the analyses warrant comment.
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