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Local Infiltration Analgesia for Postoperative Pain After Hip Arthroplasty: A Systematic Review and Meta-Analysis

  • Jun-Bin Yin
    Affiliations
    Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, PR China
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  • Guang-Bin Cui
    Affiliations
    Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, PR China

    Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, PR China
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  • Ming-Shan Mi
    Affiliations
    Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, PR China

    Department of Orthopaedics, Affiliated Hospital of Qinghai University, Xining, PR China
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  • Yu-Xia Du
    Affiliations
    Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, PR China

    Dental Department of Qinghai Provincial People's Hospital, Xining, PR China
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  • Sheng-Xi Wu
    Affiliations
    Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, PR China
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  • Yun-Qing Li
    Affiliations
    Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, PR China
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  • Wen Wang
    Correspondence
    Address reprint requests to Wen Wang, MD, PhD, Unit for Evidence Based Medicine, Department of Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an 710032, PR China.
    Affiliations
    Unit for Evidence Based Medicine, Department of Human Anatomy & K.K. Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, Xi'an, PR China
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      Abstract

      Postoperative pain after hip arthroplasty (HA) is very common and severe. Currently, use of routine analgesic methods is often accompanied by adverse events (AEs). Local infiltration analgesia (LIA) for controlling pain has been a therapeutic option in many surgical procedures. However, its analgesic efficacy in HA and its safety remain unclear. Data from 9 randomized controlled trials, involving 760 participants, comparing the effect of LIA with that of placebo infiltration or no infiltration on patients undergoing HA were retrieved from an electronic database, and the pain scores, analgesic consumption, and AEs were analyzed. Effects were summarized using weighted mean differences, standardized mean differences, or odds ratio with fixed or random effect models. There was strong evidence of an association between LIA and reduced pain scores at 4 hours at rest (P < .00001) and with motion (P < .00001), 6 hours with motion (P = .02), and 24 hours at rest (P = .01), and decreased analgesic consumption during 0 to 24 hours (P = .001) after HA. These analgesic efficacies for LIA were not accompanied by any increased risk for AEs. However, the current meta-analysis did not reveal any associations between LIA and the reduced pain scores or analgesic consumption at other time points. The results suggest that LIA can be used for controlling pain after HA because of its efficacy in reducing pain scores and thus can reduce analgesic consumption on the first day without increased risk of AEs.

      Perspective

      This is the first pooled database meta-analysis to assess the analgesic effects and safety of LIA in controlling pain after HA. The derived information offers direct evidence that LIA can be used for patients undergoing HA because of its ability to reduce pain scores and analgesic consumption without any additional AEs.

      Key words

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