- •Inhibiting the soluble epoxide hydrolase (sEH) is effective against neuropathic pain.
- •sEH inhibitors are effective against chronic pain in an operant nociceptive assay.
- •The small molecule sEH inhibitors show potent analgesia without reward side effects.
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This work was supported by the National Institute of Environmental Health Sciences (NIEHS) Grant R01 ES002710 (to B.D.H.), NIEHS Superfund Research Program P42 ES004699, National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases R21AR062866 and Grants National Institute of Environmental Health Sciences T32ES007059 and NIH 5T32DC008072-05 (to K.W.).
The University of California holds patents on the sEH inhibitors used in this study as well as their use to treat inflammation, inflammatory pain, and neuropathic pain. B.D.H. and B.I. are cofounders of Eicosis L.L.C., a startup company advancing sEH inhibitors into the clinic. K.W. and J.Y. have no conflicts of interest.
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. B.D.H. is a George and Judy Marcus Senior Fellow of the American Asthma Foundation.