- •Cortical excitability was investigated in patients with episodic cluster headache.
- •Motor cortical hyperexcitability was shown in patients both inside and outside bout.
- •Cortical excitability was asymmetric between the hemispheres.
- •Greater responses to transcranial magnetic stimulation were shown in the hemisphere ipsilateral to the pain side.
- •Abnormal cortical excitability may play a role in cluster headache pathophysiology.
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The authors declare that they have no competing interests.