Highlights
- •We carried out a meta-analysis of placebo responses in trials for long-standing CRPS.
- •There was evidence for placebo response at 15 to 30 minutes after interventions.
- •We found no evidence for placebo response at later time points.
Abstract
Perspective
Key words
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Article info
Publication history
Footnotes
G.K.M. and S.J.N. are joint first authors.
G.K.M. reports no disclosures. S.J.N. is funded as part of a 3-year research program “Clinical and Cost Effectiveness of Interventions for Epilepsy in the National Health Service (NHS),” which receives financial support from the National Institute for Health Research . T.J.N. serves/has served on scientific advisory boards for Grunenthal, Astellas, Janssen, and Pharmleads; has received speaker honoraria from Pfizer, Astellas and Medtronic; serves on the editorial boards of Pain, Clinical Journal of Pain, Current Pain and Headache Reports, and Neuromodulation; and receives research support from National Institute for Health Research (United Kingdom), Pain Relief Foundation (United Kingdom), and Pfizer Ltd. A.G. has received research support from CSL-Behring, BPL, Biotest, Talecris, Baxter and Grifols, Pfizer, travel support from CSL-Behring and Baxter, speaker honoraria from Baxter, and consultancy fees from Biotest and Axsome. The authors report no conflicts of interest. All authors contributed substantially to this work.
Supplementary data accompanying this article are available online at www.jpain.org and www.sciencedirect.com.