- •We examined the effect of OPRM1 A118 G on persistent pain following motor vehicle collision (MVC) stress.
- •Women with a G allele and distress at the time of MVC had reduced pain at 6 weeks.
- •Men with a G allele had increased pain 6 weeks following MVC.
- •Results show a sex-dependent effect of A118 G on pain development following stress.
- •Effect of OPRM1 allele on pain after stress suggests endogenous opioid-induced hyperalgesia mechanism.
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Supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number R01AR056328.
The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
No conflicts of interest exist for any of the authors.
The project described was supported by Award Number R01AR056328 from the National Institute of Arthritis and Musculoskeletal and Skin diseases.