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Bidirectional Association Between Depression and Fibromyalgia Syndrome: A Nationwide Longitudinal Study

      Highlights

      • Several cross-sectional studies have reported a common comorbidity between depression and fibromyalgia syndrome (FMS).
      • However, a bidirectional temporal association between these 2 distinct diseases has rarely been investigated.
      • Our results supported a bidirectional temporal association between depression and FMS that each disease occurring first may increase the risk of the other subsequently.

      Abstract

      Several cross-sectional studies have reported a common comorbidity between depression and fibromyalgia syndrome (FMS). However, a bidirectional temporal association between these 2 distinct diseases has rarely been investigated. Using the Taiwan National Health Insurance Research Database, 25,969 patients with FMS and without any psychiatric disorder and 17,142 patients with depression and without FMS between 2000 and 2008 were enrolled and separately compared with age- and sex-matched (1:4) control groups. Patients with FMS who developed a new-onset depression and those with depression who developed new-onset FMS were identified during follow-up (to the end of 2011). The conditional Cox regression analyses, after adjustment for demographic data and medical comorbidities, showed that the patients with FMS were associated with an increased risk (hazard ratio [HR] 7.46, 95% confidence interval [CI] 6.77–8.22) of subsequent depression and that those with depression were associated with an increased risk (HR 6.28, 95% CI 5.67–6.96) of subsequent FMS. Our results supported a bidirectional temporal association between depression and FMS. Each disease occurring first may increase the risk of the other subsequently. Further study may be necessary to determine the underlying mechanism between depression and FMS and to clarify whether a prompt intervention for depression or FMS may decrease the risk of the other later in life.

      Perspective

      Our study supported a bidirectional temporal association between depression and FMS such that each disease occurring first may increase the risk of the other subsequently. This result may imply a shared pathophysiology between FMS and depression, but further investigation is needed.

      Key words

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      References

        • Ballenger J.C.
        • Davidson J.R.
        • Lecrubier Y.
        • Nutt D.J.
        • Goldberg D.
        • Magruder K.M.
        • Schulberg H.C.
        • Tylee A.
        • Wittchen H.U.
        Consensus Statement on the Primary Care Management of Depression from the International Consensus Group on Depression and Anxiety.
        J Clin Psychiatry. 1999; 60: 54-61
        • Berger A.
        • Dukes E.
        • Martin S.
        • Edelsberg J.
        • Oster G.
        Characteristics and healthcare costs of patients with fibromyalgia syndrome.
        Int J Clin Pract. 2007; 61: 1498-1508
        • Buskila D.
        • Cohen H.
        Comorbidity of fibromyalgia and psychiatric disorders.
        Curr Pain Headache Rep. 2007; 11: 333-338
        • Castillo R.C.
        • Wegener S.T.
        • Heins S.E.
        • Haythornthwaite J.A.
        • Mackenzie E.J.
        • Bosse M.J.
        Longitudinal relationships between anxiety, depression, and pain: results from a two-year cohort study of lower extremity trauma patients.
        Pain. 2013; 154: 2860-2866
        • Chen M.H.
        • Su T.P.
        • Chen Y.S.
        • Hsu J.W.
        • Huang K.L.
        • Chang W.H.
        • Bai Y.M.
        Allergic rhinitis in adolescence increases the risk of depression in later life: a nationwide population-based prospective cohort study.
        J Affect Disord. 2013; 145: 49-53
        • Chen M.H.
        • Pan T.L.
        • Li C.T.
        • Lin W.C.
        • Chen Y.S.
        • Lee Y.C.
        • Tsai S.J.
        • Hsu J.W.
        • Huang K.L.
        • Tsai C.F.
        • Chang W.H.
        • Chen T.J.
        • Su T.P.
        • Bai Y.M.
        Risk of stroke among patients with post-traumatic stress disorder: nationwide longitudinal study.
        Br J Psychiatry. 2015; 206: 302-307
        • Dowlati Y.
        • Herrmann N.
        • Swardfager W.
        • Liu H.
        • Sham L.
        • Reim E.K.
        • Lanctot K.L.
        A meta-analysis of cytokines in major depression.
        Biol Psychiatry. 2010; 67: 446-457
        • Fietta P.
        • Fietta P.
        • Manganelli P.
        Fibromyalgia and psychiatric disorders.
        Acta Biomed. 2007; 78: 88-95
        • Forseth K.O.
        • Husby G.
        • Gran J.T.
        • Forre O.
        Prognostic factors for the development of fibromyalgia in women with self-reported musculoskeletal pain. a prospective study.
        J Rheumatol. 1999; 26: 2458-2467
        • Gerrits M.M.
        • van Oppen P.
        • Leone S.S.
        • van Marwijk H.W.
        • van der Horst H.E.
        • Penninx B.W.
        Pain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders.
        BMC Psychiatry. 2014; 14: 187
        • Gracely R.H.
        • Ceko M.
        • Bushnell M.C.
        Fibromyalgia and depression.
        Pain Res Treat. 2012; 2012: 486590
        • Gur A.
        • Karakoc M.
        • Nas K.
        • Remzi
        • Cevik
        • Denli A.
        • Sarac J.
        Cytokines and depression in cases with fibromyalgia.
        J Rheumatol. 2002; 29: 358-361
        • Hawker G.A.
        • Gignac M.A.
        • Badley E.
        • Davis A.M.
        • French M.R.
        • Li Y.
        • Perruccio A.V.
        A longitudinal study to explain the pain-depression link in older adults with osteoarthritis.
        Arthritis Care Res (Hoboken). 2011; 63: 1382-1390
        • Hudson J.I.
        • Pope Jr., H.G.
        The relationship between fibromyalgia and major depressive disorder.
        Rheum Dis Clin North Am. 1996; 22: 285-303
        • Kroenke K.
        • Wu J.
        • Bair M.J.
        • Krebs E.E.
        • Damush T.M.
        • Tu W.
        Reciprocal relationship between pain and depression: a 12-month longitudinal analysis in primary care.
        J Pain. 2011; 12: 964-973
        • Leino P.
        • Magni G.
        Depressive and distress symptoms as predictors of low back pain, neck-shoulder pain, and other musculoskeletal morbidity: a 10-year follow-up of metal industry employees.
        Pain. 1993; 53: 89-94
        • Li C.T.
        • Bai Y.M.
        • Huang Y.L.
        • Chen Y.S.
        • Chen T.J.
        • Cheng J.Y.
        • Su T.P.
        Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study.
        Br J Psychiatry. 2012; 200: 45-51
        • Li J.X.
        Pain and depression comorbidity: a preclinical perspective.
        Behav Brain Res. 2015; 276: 92-98
        • Liu Y.
        • Ho R.C.
        • Mak A.
        Interleukin (IL)-6, tumour necrosis factor alpha (TNF-alpha) and soluble interleukin-2 receptors (SIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression.
        J Affect Disord. 2012; 139: 230-239
        • Magni G.
        • Marchetti M.
        • Moreschi C.
        • Merskey H.
        • Luchini S.R.
        Chronic musculoskeletal pain and depressive symptoms in the National Health and Nutrition Examination. I. Epidemiologic follow-up study.
        Pain. 1993; 53: 163-168
        • Magni G.
        • Moreschi C.
        • Rigatti-Luchini S.
        • Merskey H.
        Prospective study on the relationship between depressive symptoms and chronic musculoskeletal pain.
        Pain. 1994; 56: 289-297
        • Maletic V.
        • Raison C.L.
        Neurobiology of depression, fibromyalgia and neuropathic pain.
        Front Biosci (Landmark Ed). 2009; 14: 5291-5338
        • Neugebauer V.
        • Li W.
        • Bird G.C.
        • Han J.S.
        The amygdala and persistent pain.
        Neuroscientist. 2004; 10: 221-234
        • Pae C.U.
        • Luyten P.
        • Marks D.M.
        • Han C.
        • Park S.H.
        • Patkar A.A.
        • Masand P.S.
        • Van Houdenhove B.
        The relationship between fibromyalgia and major depressive disorder: a comprehensive review.
        Curr Med Res Opin. 2008; 24: 2359-2371
        • Rodriguez-Pinto I.
        • Agmon-Levin N.
        • Howard A.
        • Shoenfeld Y.
        Fibromyalgia and cytokines.
        Immunol Lett. 2014; 161: 200-203
        • Shen C.C.
        • Tsai S.J.
        • Perng C.L.
        • Kuo B.I.
        • Yang A.C.
        Risk of Parkinson disease after depression: a nationwide population-based study.
        Neurology. 2013; 81: 1538-1544
        • Tariot P.N.
        • Yocum D.
        • Kalin N.H.
        Psychiatric disorders in fibromyalgia.
        Am J Psychiatry. 1986; 143: 812-813
        • Thieme K.
        • Turk D.C.
        • Flor H.
        Comorbid depression and anxiety in fibromyalgia syndrome: relationship to somatic and psychosocial variables.
        Psychosom Med. 2004; 66: 837-844
        • Vishne T.
        • Fostick L.
        • Silberman A.
        • Kupchick M.
        • Rubinow A.
        • Amital H.
        • Amital D.
        Fibromyalgia among major depression disorder females compared to males.
        Rheumatol Int. 2008; 28: 831-836
        • Wang H.
        • Moser M.
        • Schiltenwolf M.
        • Buchner M.
        Circulating cytokine levels compared to pain in patients with fibromyalgia–a prospective longitudinal study over 6 months.
        J Rheumatol. 2008; 35: 1366-1370
        • Wang H.
        • Schiltenwolf M.
        On the role of cytokines in patients with back pain and fibromyalgia.
        Schmerz. 2010; 24: 276-278
        • Weir P.T.
        • Harlan G.A.
        • Nkoy F.L.
        • Jones S.S.
        • Hegmann K.T.
        • Gren L.H.
        • Lyon J.L.
        The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes.
        J Clin Rheumatol. 2006; 12: 124-128
        • Williams L.S.
        • Jones W.J.
        • Shen J.
        • Robinson R.L.
        • Weinberger M.
        • Kroenke K.
        Prevalence and impact of depression and pain in neurology outpatients.
        J Neurol Neurosurg Psychiatry. 2003; 74: 1587-1589
        • Willoughby S.G.
        • Hailey B.J.
        • Mulkana S.
        • Rowe J.
        The effect of laboratory-induced depressed mood state on responses to pain.
        Behav Med. 2002; 28: 23-31
        • Wolfe F.
        • Smythe H.A.
        • Yunus M.B.
        • Bennett R.M.
        • Bombardier C.
        • Goldenberg D.L.
        • Tugwell P.
        The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee.
        Arthritis Rheum. 1990; 33: 160-172