- •Patients with major depressive disorder (MDD) showed increased pain sensitivity.
- •Patients with depression exhibited lower pressure pain thresholds.
- •Lower pressure pain thresholds were mediated by depression-related somatic factors.
- •Patients with depression exhibited increased levels of self-reported pain intensity.
- •Self-reported pain intensity in MDD patients was associated with anxiety symptoms.
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R.R. and H.W. contributed equally to this work.
This work was supported by the German Federal Ministry of Education and Research (BMBF, grant numbers 01ER0816 to K.B. and 01ER1205 to H.W.). The sponsor had no involvement in study design, in the collection, analysis and interpretation of data, in the writing of the report, or in the decision to submit the article for publication.
M.H., J.W., and H.W. have no conflicts of interest to declare. K.B. has received investigator-initiated research funding as principal or coordinating investigator in the areas of stroke, depression, and subclinical atherosclerosis (BiDirect), multimorbidity and health services research, diabetes, multiple sclerosis, and for the German National Cohort from the German Ministry of Education and Research. For the ongoing conduction of an investigator-initiated clinical register for multiple sclerosis he has received a grant from the German Competence Net Multiple Sclerosis with funds from Biogen Idec. For conducting (2007–2014) a study on the course of restless legs syndrome he has received unrestricted grants to the University of Muenster from the German Restless Legs Society and Boehringer Ingelheim Pharma, Mundipharma Research, Neurobiotec, Roche Pharma, UCB Germany, UCB Switzerland, and Vifor Pharma. B.T.B. is a member of the advisory board for Lundbeck. He receives funding from the National Health and Medical Research Council, Australia. R.R. has received speaker fees from Allergan, MSD, Mundipharma, and Pfizer as well as a travel grant from Allergan. She has received funding from the Else-Kröner Fresenius Stiftung and the Friedrich-Baur-Stiftung. These cooperations did not influence the work covered in the report.