- •Catastrophizing (CAT) in sickle cell disease (SCD) was assessed using 3 distinct pain referents.
- •SCD-specific CAT was greater than non-SCD or laboratory pain-related CAT.
- •SCD-specific and non-SCD CAT were associated with clinical pain.
- •Situational CAT was associated with central sensitization markers and laboratory pain.
- •Changes in situational CAT predicted later changes in laboratory pain sensitivity.
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This research was supported by the National Institutes of Health R01HL98110 (J.A.H.) and T32 NS070201 (V.A.M.).
S.L. has received research funds unrelated to this project from Pfizer, Selexys, Prolong, and Astra Zeneca and is a consultant for Apopharma and Global Blood Therapeutics. The remaining authors have no conflicts of interest to declare.