- •Prevalence of chronic pain rises with age.
- •Age-related changes in the descending modulatory pathways could be a possible mechanism.
- •We experimentally explored endogenous pain modulation in younger compared with older adults.
- •Older adults show preserved capacity for endogenous pain modulation.
- •In the future, nonpharmacological analgesic treatment strategies could be enhanced in the elderly.
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This work was supported by grants from the German Research Foundation (FOR-1328, BI 789/2-1) and the German Federal Ministry of Education and Research (FK 01GQ0808).
The authors have no conflicts of interest to declare.