- •At present, there is no sound method of identifying optimal opioid candidates.
- •Endogenous opioid function × anger-out interactions identified individuals with different response patterns.
- •Low endogenous opioid function plus low anger-out showed largest morphine analgesic responses.
- •High anger-out plus low endogenous opioid function showed weaker morphine analgesic responses.
- •High anger-out plus low endogenous opioid function showed highest side effects.
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This study was supported by grant R01 DA031726 from the National Institute of Drug Abuse/National Institutes of Health.
The authors have no conflicts of interest to declare.