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Intensity Dependence of Auditory Evoked Potentials in Primary Dysmenorrhea

  • Bingren Zhang
    Affiliations
    Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China
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  • You Xu
    Affiliations
    Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China

    Department of Psychosomatic Medicine, Mental Health Center, Zhejiang University College of Medicine, Hangzhou, China
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  • Wei He
    Affiliations
    Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China

    Department of Cogntive Science, Macquarie Univeristy, and Australian Research Council Centre of Excellence in Cognition and Its Disorders, Macquarie University, Sydney, Australia
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  • Jiawei Wang
    Affiliations
    Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China
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  • Hao Chai
    Affiliations
    Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China
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  • Chanchan Shen
    Affiliations
    Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China
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  • Qisha Zhu
    Affiliations
    Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China
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  • Wei Wang
    Correspondence
    Address reprint requests to Wei Wang, BMed, DSc, Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Yuhangtang Rd 866, Hangzhou, Zhejiang 310058, China.
    Affiliations
    Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China

    Department of Psychosomatic Medicine, Mental Health Center, Zhejiang University College of Medicine, Hangzhou, China
    Search for articles by this author

      Highlights

      • Intensity dependence of auditory potentials were recorded in primary dysmenorrhea.
      • Women with primary dysmenorrhea showed a pronounced intensity dependence.
      • Prefrontal and frontal activations were more prominent in primary dysmenorrhea.
      • These results suggest the role of central sensitization in dysmenorrhea.

      Abstract

      Some studies suggest that women with primary dysmenorrhea have distinct emotional or personality features. For example, they might exaggerate their responses to external stimuli, such as to intensity-increasing auditory stimuli. Fifteen women with primary dysmenorrhea and 15 healthy women were invited to undergo tests of the intensity dependence of auditory evoked potentials (IDAEP), the Functional and Emotional Measure of Dysmenorrhea, and the Plutchik–van Praag Depression Inventory. Study participants with dysmenorrhea showed higher Functional and Emotional scale scores and stronger IDAEP. Regarding the IDAEP generation, the source inversion of N1 and P2 disclosed the activated bilateral superior temporal gyri, medial and superior prefrontal gyri in all participants, and additionally, the middle frontal gyri in dysmenorrhea patients. We report a pronounced IDAEP in primary dysmenorrhea, which indicates the decreased cerebral serotonergic innervations and points to increased activations in the prefrontal and frontal areas in the disorder.

      Perspective

      Using an IDAEP technique, the authors found decreased serotonergic innervation and altered cerebral activation in women with primary dysmenorrhea, which might offer some pharmacotherapeutic clues for the disorder.

      Key words

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