Highlights
- •Obese patients with pain underwent a calorie-restriction weight loss intervention.
- •The spatial distribution of pain, fatigue, and depressive symptoms improved.
- •Improvement was greatest in those losing 10% or more of their body weight.
- •The anti-inflammatory cytokine interleukin-10 increased after weight loss.
Abstract
Perspective
Key words
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Article info
Publication history
Footnotes
This project was supported in part by Grant Number P30DK020572 (MDRC) from the National Institute of Diabetes and Digestive and Kidney Diseases, Grant Number K12 DE023574 from the National Institute of Dental and Craniofacial Research.
The authors have no conflicts of interest to declare. Dr. Harte has received research funding from Aptinyx, Cerephex, Forest Laboratories, Eli Lily, and Merck, and served as a consultant for Pfizer, Analgesic Solutions, Aptinyx, and deCode Genetics. Dr. Williams is currently the President of the American Pain Society; he has served as a consultant with Pfizer Inc and with Community Health Focus Inc. Dr. Clauw has received research funding from Cerephex, Forest, Merck, and Pfizer, and serves as a consultant for Tonix, Theravance, Cerephex, Pfizer, Abbott, Merck, Eli Lilly, UCB, Johnson & Johnson, Forest Laboratories, and Purdue Pharma.