- •We studied brain changes at early vs late stages of complex regional pain syndrome.
- •Early gray matter volume decrease was found in sensorimotor and parietal cortices.
- •At early stage, cerebral perfusion was reduced in parts of the limbic system.
- •We found higher perfusion in motor cortex but no gray matter changes at late stage.
- •Sensorimotor network changes at both stages showed impairment of motor control.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Efficacy of stellate ganglion blockade for the management of type 1 complex regional pain syndrome.South Med J. 2006; 99: 1084-1088
- A fast diffeomorphic image registration algorithm.Neuroimage. 2007; 38: 95-113
- Voxel-based morphometry—The methods.Neuroimage. 2000; 11: 805-821
- Functional reorganization of the default mode network across chronic pain conditions.PLoS One. 2014; 9 (e106133)
- Brain morphological signatures for chronic pain.PLoS One. 2011; 6 (e26010)
- Intended and unintended (sensory-)motor coupling between the affected and unaffected upper limb in complex regional pain syndrome.Eur J Pain. 2015; 19: 1021-1034
- Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brain.J Pain. 2014; 15: 197-203
- The outcome of complex regional pain syndrome type 1: A systematic review.J Pain. 2014; 15: 677-690
- Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome.Neuroimage Clin. 2014; 6: 347-369
- A component based noise correction method (CompCor) for BOLD and perfusion based fMRI.Neuroimage. 2007; 37: 90-101
- Complex regional pain syndrome an optimistic perspective.Neurology. 2014; 84: 89-96
- Complex regional pain syndrome—Significant progress in understanding.Pain. 2015; 156: 94-103
- Altered resting-state functional connectivity in complex regional pain syndrome.J Pain. 2013; 14: 1107-1115
- Causalgia and other reflex sympathetic dystrophies.in: Bonica J. Loeser J. Chapman C. Fordyce W. The Management of Pain. 2nd ed. Lea & Febiger London, Philadelphia1990: 220-243
- Artefactual subcortical hyperperfusion in PET studies normalized to global mean: Lessons from Parkinson's disease.Neuroimage. 2009; 45: 249-257
- Complex regional pain syndrome: Are there distinct subtypes and sequential stages of the syndrome?.Pain. 2002; 95: 119-124
- Cognitive and emotional control of pain and its disruption in chronic pain.Nat Rev Neurosci. 2013; 14: 502-511
- Pain assessment: Global use of the Brief Pain Inventory.Ann Acad Med Singapore. 1994; 23: 129-138
- Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields.Magn Reson Med. 2008; 60: 1488-1497
- The human parietal operculum. II. Stereotaxic maps and correlation with functional imaging results.Cereb Cortex. 2006; 16: 268-279
- The human parietal operculum. I. Cytoarchitectonic mapping of subdivisions.Cereb Cortex. 2006; 16: 254-267
- The Oswestry Disability Index.Spine. 2000; 25: 2940-2953
- Cerebral blood flow imaging with 3D GRASE ASL sequence increases SNR and shortens acquisition time.MAGNETOM Flash. 2009; : 62-69
- Continuous arterial spin labeling perfusion measurements using single shot 3D GRASE at 3 T.Magn Reson Med. 2005; 54: 1241-1247
- Contralateral thalamic perfusion in patients with reflex sympathetic dystrophy syndrome. Reduced bone formation after exposure to organophosphates.Lancet. 1999; 354: 1790-1791
- The brain in chronic CRPS pain: Abnormal gray-white matter interactions in emotional and autonomic regions.Neuron. 2008; 60: 570-581
- Two different areas within the primary motor cortex of man.Nature. 1996; 382: 805-807
- Areas 3a, 3b, and 1 of human primary somatosensory cortex.Neuroimage. 1999; 10: 63-83
- Human somatosensory area 2: Observer-independent cytoarchitectonic mapping, interindividual variability, and population map.Neuroimage. 2001; 14: 617-631
- Complex regional pain syndrome: Are the IASP diagnostic criteria valid and sufficiently comprehensive?.Pain. 1999; 83: 211-219
- Complex regional pain syndrome: Practical diagnostic and treatment guidelines.Pain Med. 2013; 14: 180-229
- Shape shifting pain: Chronification of back pain shifts brain representation from nociceptive to emotional circuits.Brain. 2013; 136: 2751-2768
- Alterations in resting-state regional cerebral blood flow demonstrate ongoing pain in osteoarthritis: An arterial spin-labeled magnetic resonance imaging study.Arthritis Rheum. 2012; 64: 3936-3946
- Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA A receptors.J Neurophysiol. 2011; 106: 2642-2652
- Brain imaging in fibromyalgia.Curr Pain Headache Rep. 2012; 16: 388-398
- Spatial orientation and the representation of space with parietal lobe lesions.Philos Trans R Soc Lond B Biol Sci. 1997; 352: 1411-1419
- Arterial spin-labeled MRI study of migraine attacks treated with rizatriptan.J Headache Pain. 2010; 11: 255-258
- Central opioidergic neurotransmission in complex regional pain syndrome.Neurology. 2010; 75: 129-136
- Enhanced medial prefrontal-default mode network functional connectivity in chronic pain and its association with pain rumination.J Neurosci. 2014; 34: 3969-3975
- Brain alterations and neurocognitive dysfunction in patients with complex regional pain syndrome.J Pain. 2015; 16: 580-586
- Body perception disturbance: A contribution to pain in complex regional pain syndrome (CRPS).Pain. 2007; 133: 111-119
- Quantitative cerebral blood flow mapping and functional connectivity of postherpetic neuralgia pain: A perfusion fMRI study.Pain. 2013; 154: 110-118
- The motor system shows adaptive changes in complex regional pain syndrome.Brain. 2007; 130: 2671-2687
- Complex regional pain syndromes: New pathophysiological concepts and therapies.Eur J Neurol. 2010; 17: 649-660
- Patterns of spread in complex regional pain syndrome, type I (reflex sympathetic dystrophy).Pain. 2000; 88: 259-266
- Differential effect of double-pulse TMS applied to dorsal premotor cortex and precuneus during internal operation of visuospatial information.Neuroimage. 2010; 49: 1108-1115
- Measuring the neural response to continuous intramuscular infusion of hypertonic saline by perfusion MRI.J Magn Reson Imaging. 2012; 35: 669-677
- Complex regional pain syndrome type I affects brain structure in prefrontal and motor cortex.PLoS One. 2014; 9 (e85372)
- Impaired spatial body representation in complex regional pain syndrome type 1 (CRPS I).Pain. 2012; 153: 2174-2181
- Diagnosis, mechanisms and treatment of complex regional pain syndrome.Curr Opin Anaesthesiol. 2014; 27: 494-500
- Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand.Neurology. 2003; 61: 515-519
- Functional imaging of central nervous system involvement in complex regional pain syndrome.AJNR Am J Neuroradiol. 2009; 30: 1279-1284
- Cerebral glucose metabolism change in patients with complex regional pain syndrome: A PET study.Radiat Med. 2006; 24: 335-344
- Prism adaptation to optical deviation alleviates pathologic pain.Neurology. 2007; 68: 128-133
- Alterations of contralateral thalamic perfusion in neuropathic pain.Open Neuroimag J. 2010; 4: 182-186
- Spreading of complex regional pain syndrome: Not a random process.J Neural Transm. 2011; 118: 1301-1309
- Is the brain of complex regional pain syndrome patients truly different?.Eur J Pain. 2016; 20: 1622-1633
- Arterial transit time imaging with flow encoding arterial spin tagging (FEAST).Magn Reson Med. 2003; 50: 599-607
- Neural correlates of chronic low back pain measured by arterial spin labeling.Anesthesiology. 2011; 115: 364-374
- The role of anterior cingulate cortex and precuneus in the coordination of motor behaviour.Eur J Neurosci. 2005; 22: 235-246
- A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labeling.Magn Reson Med. 2007; 58: 1020-1027
- Noise reduction in 3D perfusion imaging by attenuating the static signal in arterial spin tagging (ASSIST).Magn Reson Med. 2000; 44: 92-100
This work was supported by an operating grant from the Canadian Institutes of Health Research, grant number: MOP-119453.
The authors have no conflicts of interest to declare.