Highlight points
- •Combining medicines may have advantages compared with single-ingredient medicines.
- •Of the 27 eligible studies, most combinations (21 of 23) were of single trials.
- •Most combinations had very low or low quality of evidence.
- •The evidence is limited for combination drug therapy for back pain or sciatica.
Abstract
Key words
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Article info
Publication history
Footnotes
R.K. received a travel research fellowship from MSD Sharp & Dohme GmbH that neither funded the review nor had any influence on the review's study design, conduct, interpretation or reporting. S.M., C.G.M., A.J.M., C.L., and B.K. have previously conducted investigator-initiated noncombination drug therapy clinical trials in back pain and sciatica (ACTRN 12613000530729, ACTRN12609000966291) that received industry funding or in-kind research support; however, neither funder played any role in the study design, data collection, analysis, interpretation and reporting of either study. R.P. has no conflicts of interest to declare.
Supplementary data accompanying this article are available online at www.jpain.org and www.sciencedirect.com.
