Highlights
- •CINP in mice is associated with transcriptional changes in MMP signaling.
- •MMP9 expression is increased in small-sized DRG neurons after paclitaxel.
- •MMP9 antibody prevents paclitaxel-induced oxidative stress and neuroinflammation.
- •MMP9 antibody alleviates paclitaxel-induced mechanical allodynia in mice.
Abstract
Perspective
Key words
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The Journal of PainReferences
- Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies.Expert Rev Proteomics Informa Healthcare. 2015; 12: 445-447
- Terminal arbor degeneration—A novel lesion produced by the antineoplastic agent paclitaxel.Eur J Neurosci. 2011; 33: 1667-1676
- Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9.Mol Pain. 2012; 8: 18
- Gene expression profiling of cutaneous injured and non-injured nociceptors in SNI animal model of neuropathic pain.Sci Rep. 2017; 7: 9367
- The adhesive removal test: A sensitive method to assess sensorimotor deficits in mice.Nat Protoc. 2009; 4: 1560-1564
- Intraepidermal nerve fiber loss corresponds to the development of Taxol-induced hyperalgesia and can be prevented by treatment with minocycline.Pain. 2011; 152: 308-313
- Mechanisms involved in the development of chemotherapy-induced neuropathy.Pain Manag. 2015; 5: 285-296
- In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity.J Neurophysiol. 2007; 98: 334-344
- The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity.Biochim Biophys Acta Mol Cell Res. 2010; 1803: 55-71
Brenner DS, Golden JP, Gereau IV RW: A novel behavioral assay for measuring cold sensation in mice. PLoS One 7, 2012.
- Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?.Neurosci Lett. 2015; 596: 90-107
- Chemotherapy-induced peripheral neuropathy: limitations in current prophylactic strategies and directions for future research.Curr Med Res Opin. 2017; 33: 981-984
- Therapeutic antibodies for autoimmunity and inflammation.Nat Rev Immunol. 2010; 10: 301-316
- Quantitative assessment of tactile allodynia in the rat paw.J Neurosci Methods. 1994; 53: 55-63
- Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury.BMC Neurosci. 2002; 3: 16
- Efficient analysis of experimental observations.Annu Rev Pharmacol Toxicol. 1980; 20: 441-462
- Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain.J Neurosci. 2012; 32: 6149-6160
- Oxidative stress in the development, maintenance and resolution of paclitaxel-induced painful neuropathy.Neuroscience. 2016; 333: 13-26
- Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy.PLoS One. 2011; 6: e25212
- Clinical and preclinical perspectives on chemotherapy-induced peripheral neuropathy (CIPN): A narrative review.Br J Anaesth. 2017; 119: 737-749
- Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy.Neurosci Lett. 2006; 397: 219-223
- Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.J Clin Invest. 2008; 118: 3012-3024
- Nitroxidative signaling mechanisms in pathological pain.Trends Neurosci. 2016; 39: 862-879
- Small-fiber sensory neuropathies: Clinical course and neuropathology of idiopathic cases.Ann Neurol. 1998; 44: 47-59
- Intrathecal morphine in mice: A new technique.Eur J Pharmacol. 1980; 67: 313-316
- Neurodegenerative diseases and oxidative stress.Nat Rev Drug Discov. 2004; 3: 39-46
- TIMPs: Versatile extracellular regulators in cancer.Nat Rev Cancer. 2016; 17: 38-53
- Emerging targets in neuroinflammation-driven chronic pain.Nat Rev Drug Discov. 2014; 13: 533-548
- Matrix metalloprotease regulation of neuropathic pain.Trends Pharmacol Sci. 2009; 30: 336-340
- Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats.J Neuroinflammation. 2017; 14: 174
- Structural and functional differences between neuropathy with and without pain?.Exp Neurol. 2011; 231: 199-206
- Unraveling the truth about antioxidants: ROS and disease: Finding the right balance.Nat Med. 2014; 20: 711-713
- Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain.Nat Med. 2008; 14: 331-336
- Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study.Stroke. 2008; 39: 100-104
- Metalloproteinases and their natural inhibitors in inflammation and immunity.Nat Rev Immunol. 2013; 13: 649-665
- CD8+ T cells and endogenous IL-10 are required for resolution of chemotherapy-induced neuropathic pain.J Neurosci. 2016; 36: 11074-11083
- Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.Brain Behav Immun. 2007; 21: 686-698
- Influenza A virus induction of oxidative stress and MMP-9 is associated with severe lung pathology in a mouse model.Virus Res. 2013; 178: 411-422
- N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases.Pain. 2016; 157: 1711-1723
- The cancer chemotherapeutic paclitaxel increases human and rodent sensory neuron responses to TRPV1 by activation of TLR4.J Neurosci. 2015; 35: 13487-13500
- Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.Nature. 2006; 443: 787-795
- Prevention of Paclitaxel-induced allodynia by Minocycline: Effect on loss of peripheral nerve fibers and infiltration of macrophages in rats.Mol Pain. 2010; 6: 76
- Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter.Cell Res. 2014; 24: 1374-1377
- Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice.Mol Pain. 2012; 8: 19
Ma J, Kavelaars A, Dougherty PM, Heijnen CJ: Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source. Cancer 124:2289-2298, 2018
- Characterisation of immune and neuroinflammatory changes associated with chemotherapy-induced peripheral neuropathy.PLoS One. 2017; 12e0170814
- The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model.PLoS One. 2014; 9e100701
- Selective allosteric inhibition of MMP9 is efficacious in preclinical models of ulcerative colitis and colorectal cancer.PLoS One. 2015; 10e0127063
- Epidermal nerve fiber density: normative reference range and diagnostic efficiency.Arch Neurol. 1998; 55: 1513-1520
- Reactive oxygen species in inflammation and tissue injury.Antioxid Redox Signal. 2014; 20: 1126-1167
- Matrix metalloproteinase-9 inhibition reduces inflammation and improves motility in murine models of postoperative ileus.Gastroenterology. 2011; 141: 1283-1292
- Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy.Cancer Sci. 2008; 99: 1618-1625
- Matrix metalloproteinases as modulators of inflammation and innate immunity.Nat Rev Immunol. 2004; 4: 617-629
- A new mathematical model for relative quantification in real-time RT-PCR.Nucleic Acids Res. 2001; 29: 45e
- Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface.J Biol Chem. 2008; 283: 2822-2834
- Matrix metalloproteinases and their multiple roles in neurodegenerative diseases.Lancet Neurol. 2009; 8: 205-216
- Randomised clinical trial: A phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis.Aliment Pharmacol Ther. 2016; 44: 157-169
- Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat.Pain. 2017; 158: 1647-1655
- Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.Pain. 2014; 155: 2461-2470
- Different immune cells mediate mechanical pain hypersensitivity in male and female mice.Nat Neurosci. 2015; 18: 1081-1083
- Increased interleukin-6 activity associated with painful chemotherapy-induced peripheral neuropathy in women after breast cancer treatment.Nurs Res Pract Hindawi. 2010; 2010281531
- Is there new hope for therapeutic matrix metalloproteinase inhibition?.Nat Rev Drug Discov. 2014; 13: 904-927
- Imaging ROS signaling in cells and animals.J Mol Med. 2013; 91: 917-927
- PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update.Nucleic Acids Res. 2012; 40: D1144-D1149
- The contribution of satellite glial cells to chemotherapy-induced neuropathic pain.Eur J Pain. 2013; 17: 571-580
- Monoclonal antibodies: Versatile platforms for cancer immunotherapy.Nat Rev Immunol. 2010; 10: 317-327
- Activation of TLR-4 to produce tumour necrosis factor-α in neuropathic pain caused by paclitaxel.Eur J Pain. 2015; 19: 889-898
- Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.Nat Med. 2015; 21: 1326-1331
- Metalloproteinases: mediators of pathology and regeneration in the CNS.Nat Rev Neurosci. 2005; 6: 931-944
- Induction of MMP-9 expression and endothelial injury by oxidative stress after spinal cord injury.J Neurotrauma. 2008; 25: 184-195
- Dorsal root ganglion infiltration by macrophages contributes to paclitaxel chemotherapy-induced peripheral neuropathy.J Pain. 2016; 17: 775-786
- Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of paclitaxel-induced painful neuropathy.J Pain. 2012; 13: 293-303
- Interleukin-6: An emerging regulator of pathological pain.J Neuroinflammation. 2016; 13: 141
Article info
Publication history
Footnotes
This work has been partially funded by the NIH/NINDS R21 NS106264 and by the Gardner Neuroscience Institute Pilot Award 2017 from the University of Cincinnati.
The authors have no conflicts of interest to declare.
Supplementary data accompanying this article are available online at www.jpain.org and www.sciencedirect.com.