- •Peripheral nociception induced gain of spatial and temporal plasticity in the primary somatosensory cortex.
- •Excitatory transmission was enhanced with both presynaptic and postsynaptic ingredients.
- •Inhibitory transmission was reduced with loss of gamma-amino butyric acid-A function.
- •The excitatory/inhibitory imbalance may contribute to the plastic changes in the primary somatosensory cortex.
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Supported by the following funds: The National Basic Research (973) Program of China 2006CB500800, National Natural Science Foundation of China grants (30670692 and 30770668), the Natural Science Foundation of Shandong Province (ZR2015CQ015 and ZR2015HQ028), and the Growth Project of Military Medical Science and Technology Youth Training Program (16QNP063).
The authors have no conflicts of interest to declare.