- •Infraorbital nerve injury induces primary and secondary orofacial hyperalgesia.
- •Cavα2δ1 contributes to the development of secondary orofacial hyperalgesia.
- •Cavα2δ1 mediates secondary orofacial hyperalgesia through PKC-TRPA1/GJ pathway.
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Authors’ contributions: YX.C. and WQ.C. designed the experiments and wrote the paper; WQ.C., YX.C., F.X., and T.C. carried out most of the experiments and image analysis; L.G., Y.F., XM.H., W.Y., LX.D., and WW.Z. performed the experiments; QL.MY., WL.M., and YQ.W. provided valuable advice on the research. All authors discussed the results and the manuscript.
Disclosures: This study was financially supported by National Natural Science Foundation of China (81971056, 31600852, 81771202, 81873101), National Key R&D Program of China (2017YFB0403803), and Development Project of Shanghai Peak Disciplines-Integrated Medicine (20180101).
The authors declare that there is no conflict of interest regarding the publication of this paper.