Highlights
- •The biochemical pathways related to oxylipins were outlined.
- •Genes encoding oxylipin related enzymes are expressed in the pain-circuit.
- •Gene expression and oxylipin concentrations were modified by inflammation.
- •Oxylipin injections evoked thermal nociceptive hypersensitivity in rats.
Abstract
Perspective
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Article info
Publication history
Footnotes
A.F.D. and M.R.S. contributed equally to this work.
M.J.I. and C.E.R. contributed equally to this work.
This work was supported by the intramural research programs of the National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Center for Complementary and Integrative Health and the National Institutes of Health Clinical Center. Supplemental funding was provided by the NIH Benth-to-Bedside Program to M.J.I. from NCCIH, and the Office of Behavioral and Social Sciences. The NIA (NIH) has claimed intellectual property related to analogs of oxidized lipids (PCT/US2018/041086;), with C.E.R. and G.S.K. named as inventors.
The authors have no conflicts of interest to declare.