- •EMLA caused significant reductions in capsaicin-induced pain compared with placebo.
- •EMLA enhanced capsaicin-induced superficial blood perfusion.
- •Capsaicin reduced the neurogenic flare induced by histamine compared with EMLA.
- •Topical analgesic pretreatment does not interfere with capsaicin desensitization.
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Disclosures: Center for Neuroplasticity and Pain (CNAP) is supported by the Danish National Research Foundation (DNRF121). The authors have no conflict of interest to report.
Statement of exclusivity: The data included in the present paper have not been published elsewhere.