- •Experimental pain had opposite effects on corticomotor excitability in hand and knee.
- •Effects in target muscles did not persist beyond period of pain.
- •Hand pain elicited a remote increase in corticomotor excitability in a knee muscle.
- •No effect of knee pain on corticomotor excitability in a hand muscle.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Motor consequences of experimentally induced limb pain: A systematic review.Eur J Pain. 2013; 17: 145-157
- The nature of anterior knee pain following injection of hypertonic saline into the infrapatellar fat pad.J Orthop Res. 2004; 22: 116-121
- Effect of cutaneous heat pain on corticospinal excitability of the tibialis anterior at rest and during submaximal contraction.Neural Plast. 2018; (2018)8713218
- Corticospinal projections to upper and lower limb spinal motoneurons in man.Electroencephalogr Clin Neurophysiol. 1990; 76: 509-519
- Primary sensory and motor cortex function in response to acute muscle pain: A systematic review and meta-analysis.Eur J Pain. 2016; 20: 1203-1213
- Reduced short- and long-latency afferent inhibition following acute muscle pain: A potential role in the recovery of motor output.Pain Med. 2016; 17: 1343-1352
- Altered primary motor cortex structure, organization, and function in chronic pain: A systematic review and meta-analysis.J Pain. 2018; 19: 341-359
- Evaluations of inhibitory effect on the motor cortex by cutaneous pain via application of capsaicin.Electromyogr Clin Neurophysiol. 2003; 43: 203-210
- An interneuronal relay for group I and II muscle afferents in the midlumbar segments of the cat spinal cord.J Physiol. 1987; 389: 647-674
- Transient inhibition of the human motor cortex by capsaicin-induced pain. A study with transcranial magnetic stimulation.Neurosci Lett. 2001; 314: 97-101
- Location-specific responses to nociceptive input support the purposeful nature of motor adaptation to pain.Pain. 2018; 159: 2192-2200
- Staehelin Jensen T: Stimulus–response functions in areas with experimentally induced referred muscle pain — A psychophysical study.Brain Res. 1997; 744: 121-128
- Arendt-Nielsen L: Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.Pain. 2000; 85: 483-491
- Experimental knee pain reduces muscle strength.J Pain. 2011; 12: 460-467
- Moving differently in pain: A new theory to explain the adaptation to pain.Pain. 2011; 152: S90-S98
- Progressive statistics for studies in sports medicine and exercise science.Med Sci Sports Exerc. 2009; 41: 3-13
- Corticospinal inhibition of transmission in propriospinal-like neurones during human walking.Eur J Neurosci. 2008; 28: 1351-1361
- Sensory modulation of voluntary and TMS-induced activation in hand muscles.Exp Brain Res. 2008; 188: 399-409
- Differential corticomotor excitability responses to hypertonic saline-induced muscle pain in forearm and hand muscles.Neural Plast. 2018; 20187589601
- Arendt-Nielsen L: Inhibition of motor system excitability at cortical and spinal level by tonic muscle pain.Clin Neurophysiol. 2001; 112: 1633-1641
- The pain-adaptation model: A discussion of the relationship between chronic musculoskeletal pain and motor activity.Can J Physiol Pharmacol. 1991; 69: 683-694
- Cortical control of spinal pathways mediating group II excitation to human thigh motoneurones.J Physiol. 1999; 517: 301-313
- Group III and IV muscle afferents differentially affect the motor cortex and motoneurones in humans.J Physiol. 2008; 586: 1277-1289
- Induced anterior knee pain immediately reduces involuntary and voluntary quadriceps activation.Clin J Sport Med. 2013; 23: 19-24
- The effects of experimental knee pain on lower limb corticospinal and motor cortex excitability.Arthritis Res Ther. 2015; 17: 204
- Experimental knee pain impairs submaximal force steadiness in isometric, eccentric, and concentric muscle actions.Arthritis Res Ther. 2015; 17: 259
- Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application. Report of an IFCN committee.Electroencephalogr Clin Neurophysiol. 1994; 91: 79-92
- New insight into the time-course of motor and sensory system changes in pain.PLoS ONE. 2015; 10 (e0142857-e0142857)
- Motor cortex reorganization and impaired function in the transition to sustained muscle pain.Cereb Cortex. 2016; 26: 1878-1890
- Muscle pain differentially modulates short interval intracortical inhibition and intracortical facilitation in primary motor cortex.J Pain. 2012; 13: 187-194
- Temporal association between changes in primary sensory cortex and corticomotor output during muscle pain.Neuroscience. 2013; 235: 159-164
- Movement does not promote recovery of motor output following acute experimental muscle pain.Pain Med. 2018; 19: 608-614
- Suppression of motor evoked potentials in a hand muscle following prolonged painful stimulation.Eur J Pain. 2003; 7: 55-62
- Different short-term modulation of cortical motor output to distal and proximal upper-limb muscles during painful sensory nerve stimulation.Muscle Nerve. 2004; 29: 663-669
The study was funded by the Auckland University of Technology. TGN is part of the Center for Neuroplasticity and Pain (CNAP) supported by the Danish National Research Foundation (DNRF121).
Conflicts of interest: The authors report no conflicts of interest.