Highlights
- •MMP-2 and MMP-9 play important roles in inflammation and in pain processes.
- •MMP-2 and MMP-9 were analyzed in CRPS, pain controls and healthy people (skin/serum).
- •Ipsilateral MMP-2 and contralateral MMP-9 were lower in CRPS with trophic changes.
- •MMP-2 (contra-) and MMP-9 (ipsi- and contralateral) correlated with CRPS severity.
- •MMP-2 and MMP-9 are differently expressed depending on clinical phenotype in CRPS.
Abstract
Perspective
Key Words
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The Journal of PainReferences
- Hyperthermia up-regulates matrix metalloproteinases and accelerates basement membrane degradation in experimental stroke.Neurosci Lett. 2011; 495: 135-139
- Canine TIMP-2: purification, characterization and molecular detection.Vet J. 2000; 160: 126-134
- Complex regional pain syndrome - phenotypic characteristics and potential biomarkers.Nat Rev Neurol. 2018; 14: 272-284
- Activation of cutaneous immune responses in complex regional pain syndrome.J Pain. 2014; 15: 485-495
- The Rodent tibia fracture model: a critical review and comparison with the complex regional pain syndrome literature.J Pain. 2018; 19: 1102.e1101-1102.e1119
- Cytokine regulation of MMP-9 in peripheral glia: implications for pathological processes and pain in injured nerve.Brain Behav Immun. 2007; 21: 561-568
- Altered fracture repair in the absence of MMP9.Development. 2003; 130: 4123-4133
- Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure?.Circ Res. 2001; 89: 201-210
- Usefulness of metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in clinical characterisation of children with newly diagnosed Crohn’s disease.J Paediatr Child Health. 2020; 56: 1233-1241
- The pro and the active form of matrix metalloproteinase-9 is increased in serum of patients with amyotrophic lateral sclerosis.J Neuroimmunol. 2005; 159: 146-154
- Complex regional pain syndrome (CRPS): An update.Der Anaesthesist. 2019; 68: 115-128
- Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase-9/2 in mice.Eur J Pain. 2018; 22: 272-281
- Influence of hydrogencalcium salts of oxidized cellulose on MMP-2, MMP-9 and TNF-alpha production and wound healing in non-healing wounds.Acta Dermatovener Cr. 2013; 21: 219-223
Gauss CF (Akademie der Wissenschaften (Göttingen GSe. Carl Friedrich Gauss Werke. Wahrscheinlichkeitsrechnung und Geometrie. Universitäts-Druckerei (Göttingen) 1863-1906.4, 1863
- MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in patients with rheumatoid arthritis and psoriatic arthritis.Clin Exp Rheumatol. 2004; 22: 335-338
- Complex regional pain syndrome patient immunoglobulin M has pronociceptive effects in the skin and spinal cord of tibia fracture mice.Pain. 2020; 161: 797-809
- The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes.Matrix Biol. 2019; 75-76: 102-113
- Objectification of the diagnostic criteria for CRPS.Pain Med. 2010; 11: 1212-1215
- Matrix-Metalloproteinasen.in: Gressner A.M. Arndt T. Lexikon der Medizinischen Laboratoriumsdiagnostik. Springer Berlin Heidelberg, Berlin, Heidelberg2019: 1589-1590 (Eds.)
- Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1.Mediators Inflamm. 2006; 2006: 28398
- Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1-induced mechanisms.in: Proceedings of the National Academy of Sciences of the United States of America. 116. 2019: 13067-13076
- 6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression.An Acad Bras Cienc. 2017; 89: 2707-2717
- Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and TGF-β expression.Drug Des Devel Ther. 2015; 9: 5373-5383
- The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis.J Immunol. 2002; 169: 2643-2647
- Identification of clustered cells in human hair follicle responsible for MMP-9 gelatinolytic activity: consequences for the regulation of hair growth.Int J Dermatol. 2001; 40: 385-392
- Increasing the reliability and validity of pain intensity measurement in chronic pain patients.Pain. 1993; 55: 195-203
- Genome-wide expression profiling of complex regional pain syndrome.PloS one. 2013; 8: e79435
- A systematic evaluation of blood serum and plasma pre-analytics for metabolomics cohort studies.Int J Mol Sci. 2016; 17
- Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain.Nat Med. 2008; 14: 331-336
- Matrix metalloproteinases MMP-2 and MMP-9 in denervated muscle and injured nerve.Neuropathol Appl Neurobiol. 1998; 24: 309-319
- Role of neuropeptide, cytokine, and growth factor signaling in complex regional pain syndrome.Pain Med. 2010; 11: 1239-1250
- The serum protease network-one key to understand complex regional pain syndrome pathophysiology.Pain. 2019; 160: 1402-1409
- The serum protease network-one key to understand complex regional pain syndrome pathophysiology.Pain. 2019; 160: 1402-1409
- TNF-alpha in CRPS and 'normal' trauma–significant differences between tissue and serum.Pain. 2011; 152: 285-290
- Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinases-1.J Exp Med. 1996; 184: 2311-2326
- Ratios of activated matrix metalloproteinase-9 to tissue inhibitor of matrix metalloproteinase-1 in wound fluids are inversely correlated with healing of pressure ulcers.Wound Repair Regen. 2002; 10: 26-37
- The dual personalities of matrix metalloproteinases in inflammation.Front Biosci. 2007; 12: 1475-1487
- Activation of matrix metalloproteinase-9 by TNF-alpha in human urinary bladder cancer HT1376 cells: the role of MAP kinase signaling pathways.Oncol Rep. 2008; 19: 1007-1013
- Mmp-9 immunoreactivity in acute migraine.Headache. 2007; 47: 698-702
- Matrix metalloproteinase upregulation in chronic inflammatory demyelinating polyneuropathy and nonsystemic vasculitic neuropathy.Neurology. 1999; 53: 62-70
Lian S, Xia Y, Khoi PN, Ung TT, Yoon HJ, Kim NH, Kim KK, Jung YD. Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-small ka, CyrillicB, and AP-1 pathways in human endothelial cells. Toxicology 338:104-116, 2015
Lindsey ML. MMP induction and inhibition in myocardial infarction. Heart Fail Rev 9:7-19, 2004
Liu D, Zhang R, Wu J, Pu Y, Yin X, Cheng Y, Wu J, Feng C, Luo Y, Zhang J. Interleukin-17A promotes esophageal adenocarcinoma cell invasiveness through ROS-dependent, NF-kappaB-mediated MMP-2/9 activation. Oncol Rep 37:1779-1785, 2017
Liu YE, Wang M, Greene J, Su J, Ullrich S, Li H, Sheng S, Alexander P, Sang QA, Shi YE. Preparation and characterization of recombinant tissue inhibitor of metalloproteinase 4 (TIMP-4). J Biol Chem 272:20479-20483, 1997
Maeda A, Sobel RA. Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions. J Neuropathol Exp Neurol 55:300-309, 1996
Mawrin C, Brunn A, Rocken C, Schroder JM. Peripheral neuropathy in systemic lupus erythematosus: pathomorphological features and distribution pattern of matrix metalloproteinases. Acta Neuropathol 105:365-372, 2003
Nagase H, Woessner JF, Jr. Matrix metalloproteinases. J Biol Chem 274:21491-21494, 1999
Park JY, Park JH, Kim SJ, Kwon JE, Kang HY, Lee ES, Kim YC. Two histopathological patterns of postinflammatory hyperpigmentation: epidermal and dermal. J Cutan Pathol 44:118-124, 2017
Rayment EA, Upton Z. Finding the culprit: a review of the influences of proteases on the chronic wound environment. Int J Low Extrem Wounds 8:19-27, 2009
Rohani MG, Parks WC. Matrix remodeling by MMPs during wound repair. Matrix Biol 44-46:113-121, 2015
Rolke R, Baron R, Maier C, Tolle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Botefur IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihofner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. Quantitative sensory testing in the german research network on neuropathic pain (DFNS): standardized protocol and reference values. Pain 123:231-243, 2006
Rolke R, Baron R, Maier C, Tolle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Botefur IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihofner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. Quantitative sensory testing in the german research network on neuropathic pain (DFNS): Standardized protocol and reference values (vol 123, pg 231, 2006). Pain 125:197-197, 2006
Rosenberg GA. Matrix metalloproteinases in neuroinflammation. Glia 39:279-291, 2002
Schaefer L, Han X, August C, Matzkies F, Lorenz T, Schaefer RM. Differential regulation of glomerular gelatinase B (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in obese Zucker rats. Diabetologia 40:1035-1043, 1997
Shubayev VI, Myers RR. Upregulation and interaction of TNFalpha and gelatinases A and B in painful peripheral nerve injury. Brain Res 855:83-89, 2000
Siebert H, Dippel N, Mader M, Weber F, Bruck W. Matrix metalloproteinase expression and inhibition after sciatic nerve axotomy. J Neuropathol Exp Neurol 60:85-93, 2001
Skiles JW, Gonnella NC, Jeng AY. The design, structure, and clinical update of small molecular weight matrix metalloproteinase inhibitors. Curr Med Chem 11:2911-2977, 2004
Stetler-Stevenson WG. Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention. J Clin Investig 103:1237-1241, 1999
Tardaguila-Garcia A, Garcia-Morales E, Garcia-Alamino JM, Alvaro-Afonso FJ, Molines-Barroso RJ, Lazaro-Martinez JL. Metalloproteinases in chronic and acute wounds: A systematic review and meta-analysis. Wound Repair Regen 27:415-420, 2019
Toth M, Sohail A, Fridman R. Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography. Methods Mol Biol 878:121-135, 2012
Uceyler N, Eberle T, Rolke R, Birklein F, Sommer C. Differential expression patterns of cytokines in complex regional pain syndrome. Pain 132:195-205, 2007
Uceyler N, Kafke W, Riediger N, He L, Necula G, Toyka KV, Sommer C. Elevated proinflammatory cytokine expression in affected skin in small fiber neuropathy. Neurology 74:1806-1813, 2010
Xue M, McKelvey K, Shen K, Minhas N, March L, Park SY, Jackson CJ. Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology 53:2270-2279, 2014
Yin N, Tan X, Liu H, He F, Ding N, Gou J, Yin T, He H, Zhang Y, Tang X. A novel indomethacin/methotrexate/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic treatment of rheumatoid arthritis. Nanoscale 12:8546-8562, 2020
Yin Y, Guo R, Shao Y, Ge M, Miao C, Cao L, Yang Y, Hu L. Pretreatment with resveratrol ameliorate trigeminal neuralgia by suppressing matrix metalloproteinase-9/2 in trigeminal ganglion. Int Immunopharmacol 72:339-347, 2019
Yong VW. Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat Rev Neurosci 6:931-944, 2005
Article info
Publication history
Footnotes
Disclosures: Supported by the BGW, DFG Bi 579/10, DFG 579/11 and the European Commission FP7 program (ncRNAPain, grant agreement 602133). Authors report no conflict of interest.
