As The Journal embarks on its 10th year of publication, we will mark this important milestone with a series of review and special articles that explore the most vital topics of pain research, presented by leaders in both laboratories and treatment clinics. The introductory article, Endothelin Receptors and Pain, by Alla Khodorova, Jean-Pierre Montmayeaur and Gary Strichartz, appears in this issue.1 The authors discuss endogenous endothelin peptides and their participation in pain-related processes.